Targeting glucose metabolism in patients with cancer von Elf, Shannon E., Chen, Jing

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Predicting drug resistance von Arellano, Nicole S, Elf, Shannon E

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The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior von Liu, Yan, Elf, Shannon E., Asai, Takashi, Miyata, Yasuhiko, Liu, Yuhui, Sashida, Goro, Huang, Gang, Di Giandomenico, Silvana, Koff, Andrew, Nimer, Stephen D.

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p53 Regulates Hematopoietic Stem Cell Quiescence von YAN LIU, ELF, Shannon E, ANTIPIN, Jack, REVA, Boris, KOFF, Andrew, NIMER, Stephen D, MIYATA, Yasuhiko, SASHIDA, Goro, YUHUI LIU, GANG HUANG, DI GIANDOMENICO, Silvana, LEE, Jennifer M, DEBLASIO, Anthony, MENENDEZ, Silvia

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Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity von Fan, Hao, Xia, Siyuan, Xiang, Junhong, Li, Yuancheng, Ross, Matthew O., Lim, Seon Ah, Yang, Fan, Tu, Jiayi, Xie, Lishi, Dougherty, Urszula, Zhang, Freya Q., Zheng, Zhong, Zhang, Rukang, Wu, Rong, Dong, Lei, Su, Rui, Chen, Xiufen, Althaus, Thomas, Riedell, Peter A., Jonker, Patrick B., Muir, Alexander, Lesinski, Gregory B., Rafiq, Sarwish, Dhodapkar, Madhav V., Stock, Wendy, Odenike, Olatoyosi, Patel, Anand A., Opferman, Joseph, Tsuji, Takemasa, Matsuzaki, Junko, Shah, Hardik, Faubert, Brandon, Elf, Shannon E., Layden, Brian, Bissonnette, B. Marc, He, Yu-Ying, Kline, Justin, Mao, Hui, Odunsi, Kunle, Gao, Xue, Chi, Hongbo, He, Chuan, Chen, Jing

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Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth von Fan, Jun, Lin, Ruiting, Xia, Siyuan, Chen, Dong, Elf, Shannon E., Liu, Shuangping, Pan, Yaozhu, Xu, Haidong, Qian, Zhiyu, Wang, Mei, Shan, Changliang, Zhou, Lu, Lei, Qun-Ying, Li, Yuancheng, Mao, Hui, Lee, Benjamin H., Sudderth, Jessica, DeBerardinis, Ralph J., Zhang, Guojing, Owonikoko, Taofeek, Gaddh, Manila, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Kang, Sumin, Doetsch, Paul W., Lonial, Sagar, Boggon, Titus J., Curran, Walter J., Chen, Jing

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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells von Chen, Dong, Xia, Siyuan, Zhang, Rukang, Li, Yuancheng, Famulare, Christopher A., Fan, Hao, Wu, Rong, Wang, Mei, Zhu, Allen C., Elf, Shannon E., Su, Rui, Dong, Lei, Arellano, Martha, Blum, William G., Mao, Hui, Lonial, Sagar, Stock, Wendy, Odenike, Olatoyosi, Le Beau, Michelle, Boggon, Titus J., He, Chuan, Chen, Jianjun, Gao, Xue, Levine, Ross L., Chen, Jing

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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells von Zhang, Rukang, Chen, Dong, Fan, Hao, Wu, Rong, Tu, Jiayi, Zhang, Freya Q., Wang, Mei, Zheng, Hong, Qu, Cheng-Kui, Elf, Shannon E., Faubert, Brandon, He, Yu-Ying, Bissonnette, Marc B., Gao, Xue, DeBerardinis, Ralph J., Chen, Jing

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Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal von Zhao, Xinghui, Chen, Aili, Yan, Xiaomei, Zhang, Yue, He, Fuhong, Hayashi, Yoshihiro, Dong, Yunzhu, Rao, Yalan, Li, Bo, Conway, Rajeana M., Maiques-Diaz, Alba, Elf, Shannon E., Huang, Nuomin, Zuber, Johannes, Xiao, Zhijian, Tse, William, Tenen, Daniel G., Wang, Qianfei, Chen, Wei, Mulloy, James C., Nimer, Stephen D., Huang, Gang

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Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms von Ibarra, Juan, Elbanna, Yassmin A, Kurylowicz, Katarzyna, Ciboddo, Michele, Greenbaum, Harrison S, Arellano, Nicole S, Rodriguez, Deborah, Evers, Maria, Bock-Hughes, Althea, Liu, Chenyu, Smith, Quinn, Lutze, Julian, Baumeister, Julian, Kalmer, Milena, Olschok, Kathrin, Nicholson, Benjamin, Silva, Diane, Maxwell, Luke, Dowgielewicz, Jonathan, Rumi, Elisa, Pietra, Daniela, Casetti, Ilaria Carola, Catricala, Silvia, Koschmieder, Steffen, Gurbuxani, Sandeep, Schneider, Rebekka K, Oakes, Scott A, Elf, Shannon E

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Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus von Liu, Yan, Liu, Fan, Yu, Hao, Zhao, Xinyang, Sashida, Goro, Deblasio, Anthony, Harr, Michael, She, Qing-Bai, Chen, Zhenbang, Lin, Hui-Kuan, Di Giandomenico, Silvana, Elf, Shannon E, Yang, Youyang, Miyata, Yasuhiko, Huang, Gang, Menendez, Silvia, Mellinghoff, Ingo K, Rosen, Neal, Pandolfi, Pier Paolo, Hedvat, Cyrus V, Nimer, Stephen D

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JAK out of the box: myeloproliferative neoplasms-associated JAK2 V617F mutations contribute to aortic aneurysms von Elf, Shannon E.

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Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling von Shan, Changliang, Elf, Shannon E., Gu, Ting-Lei, Khoury, Hanna J., Boggon, Titus, Kang, Sumin, Chen, Jing

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Abstract LB134: Type 1 calreticulin mutations differentially activate the IRE1α-XBP1 pathway of the unfolded protein response to drive myeloproliferative neoplasms von Ibarra, Juan, Elbanna, Yassmin, Kurylowicz, Katarzyna, Ciboddo, Michele, Greenbaum, Harrison S., Arellano, Nicole S., Rodriguez, Deborah, Evers, Maria, Yang, Dongbo, Bock-Hughes, Althea, Liu, Chenyu, Smith, Quinn, Baumeister, Julian, Kalmer, Milena, Olschok, Kathrin, Nicholson, Benjamin, Silva, Diane, Dowgielewicz3, Jonathan, Rumi, Elisa, Pietra, Daniela, Casetti, Ilaria Carola, Koschmieder5, Steffen, Gurbuxani, Sandeep, Schneider, Rebekka K., Oakes, Scott A., Elf, Shannon E.

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RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development von Yan, Xiaomei, Hayashi, Yoshihiro, Zhao, Xinghui, Chen, Aili, Zhang, Yue, He, Fuhong, Dong, Yunzhu, Rao, Yalan, Li, Bo, Conway, Rajeana, Maiques-Díaz, Alba, Huang, Nuomin, Elf, Shannon E, Zuber, Johannes, Xiao, Zhijian, Tse, William, Tenen, Daniel G., Wang, Qianfei, Chen, Wei, Mulloy, James C., Nimer, Stephen D, Huang, Gang

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Regulation of Hematopoietic Stem Cell Quiescence - A Novel Role for p53 von Liu, Yan, Elf, Shannon E., Miyata, Yasuhiko, Sashida, Goro, Deblasio, Anthony D., Liu, Yuhui, Koff, Andrew, Nimer, Stephen D.

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Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN von Gleitz, Hélène F.E., Dugourd, Aurélien J.F., Leimkühler, Nils B., Snoeren, Inge A.M., Fuchs, Stijn N.R., Menzel, Sylvia, Ziegler, Susanne, Kröger, Nicolaus, Triviai, Ioanna, Büsche, Guntram, Kreipe, Hans, Banjanin, Bella, Pritchard, Jessica E., Hoogenboezem, Remco, Bindels, Eric M., Schumacher, Neele, Rose-John, Stefan, Elf, Shannon, Saez-Rodriguez, Julio, Kramann, Rafael, Schneider, Rebekka K.

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A reference human induced pluripotent stem cell line for large-scale collaborative studies von Pantazis, Caroline B., Yang, Andrian, Lara, Erika, McDonough, Justin A., Blauwendraat, Cornelis, Peng, Lirong, Oguro, Hideyuki, Kanaujiya, Jitendra, Zou, Jizhong, Sebesta, David, Pratt, Gretchen, Cross, Erin, Blockwick, Jeffrey, Buxton, Philip, Kinner-Bibeau, Lauren, Medura, Constance, Tompkins, Christopher, Hughes, Stephen, Santiana, Marianita, Faghri, Faraz, Nalls, Mike A., Vitale, Daniel, Ballard, Shannon, Qi, Yue A., Ramos, Daniel M., Anderson, Kailyn M., Stadler, Julia, Narayan, Priyanka, Papademetriou, Jason, Reilly, Luke, Nelson, Matthew P., Aggarwal, Sanya, Rosen, Leah U., Kirwan, Peter, Pisupati, Venkat, Coon, Steven L., Scholz, Sonja W., Priebe, Theresa, Öttl, Miriam, Dong, Jian, Meijer, Marieke, Janssen, Lara J.M., Lourenco, Vanessa S., van der Kant, Rik, Crusius, Dennis, Paquet, Dominik, Raulin, Ana-Caroline, Bu, Guojun, Held, Aaron, Wainger, Brian J., Gabriele, Rebecca M.C., Casey, Jackie M., Wray, Selina, Abu-Bonsrah, Dad, Parish, Clare L., Beccari, Melinda S., Cleveland, Don W., Li, Emmy, Rose, Indigo V.L., Kampmann, Martin, Calatayud Aristoy, Carles, Verstreken, Patrik, Heinrich, Laurin, Chen, Max Y., Schüle, Birgitt, Dou, Dan, Holzbaur, Erika L.F., Zanellati, Maria Clara, Basundra, Richa, Deshmukh, Mohanish, Cohen, Sarah, Khanna, Richa, Raman, Malavika, Nevin, Zachary S., Matia, Madeline, Van Lent, Jonas, Timmerman, Vincent, Conklin, Bruce R., Johnson Chase, Katherine, Zhang, Ke, Funes, Salome, Bosco, Daryl A., Erlebach, Lena, Welzer, Marc, Kronenberg-Versteeg, Deborah, Lyu, Guochang, Arenas, Ernest, Coccia, Elena, Sarrafha, Lily, Ahfeldt, Tim, Marioni, John C., Skarnes, William C., Cookson, Mark R., Ward, Michael E., Merkle, Florian T.

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Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation von Iwasaki, Hiromi, Somoza, Chamorro, Shigematsu, Hirokazu, Duprez, Estelle A., Iwasaki-Arai, Junko, Mizuno, Shin-ichi, Arinobu, Yojiro, Geary, Kristin, Zhang, Pu, Dayaram, Tajhal, Fenyus, Maris L., Elf, Shannon, Chan, Susan, Kastner, Philippe, Huettner, Claudia S., Murray, Richard, Tenen, Daniel G., Akashi, Koichi

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Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs von Jutzi, Jonas S, Marneth, Anna E, Ciboddo, Michele, Guerra-Moreno, Angel, Jiménez-Santos, María José, Kosmidou, Anastasia, Dressman, James W, Liang, Hongyan, Hamel, Rebecca, Lozano, Patricia, Rumi, Elisa, Doench, John G, Gotlib, Jason, Krishnan, Anandi, Elf, Shannon, Al-Shahrour, Fátima, Mullally, Ann

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