Evolutionary History and Adaptation from High-Coverage Whole-Genome Sequences of Diverse African Hunter-Gatherers von Lachance, Joseph, Vernot, Benjamin, Elbers, Clara C., Ferwerda, Bart, Froment, Alain, Bodo, Jean-Marie, Lema, Godfrey, Fu, Wenqing, Nyambo, Thomas B., Rebbeck, Timothy R., Zhang, Kun, Akey, Joshua M., Tishkoff, Sarah A.

Volltext

Mendelian randomization of blood lipids for coronary heart disease von Holmes, Michael V, Asselbergs, Folkert W, Palmer, Tom M, Drenos, Fotios, Lanktree, Matthew B, Nelson, Christopher P, Dale, Caroline E, Padmanabhan, Sandosh, Finan, Chris, Swerdlow, Daniel I, Tragante, Vinicius, van Iperen, Erik P A, Sivapalaratnam, Suthesh, Shah, Sonia, Elbers, Clara C, Shah, Tina, Engmann, Jorgen, Giambartolomei, Claudia, White, Jon, Zabaneh, Delilah, Sofat, Reecha, McLachlan, Stela, Doevendans, Pieter A, Balmforth, Anthony J, Hall, Alistair S, North, Kari E, Almoguera, Berta, Hoogeveen, Ron C, Cushman, Mary, Fornage, Myriam, Patel, Sanjay R, Redline, Susan, Siscovick, David S, Tsai, Michael Y, Karczewski, Konrad J, Hofker, Marten H, Verschuren, W Monique, Bots, Michiel L, van der Schouw, Yvonne T, Melander, Olle, Dominiczak, Anna F, Morris, Richard, Ben-Shlomo, Yoav, Price, Jackie, Kumari, Meena, Baumert, Jens, Peters, Annette, Thorand, Barbara, Koenig, Wolfgang, Gaunt, Tom R, Humphries, Steve E, Clarke, Robert, Watkins, Hugh, Farrall, Martin, Wilson, James G, Rich, Stephen S, de Bakker, Paul I W, Lange, Leslie A, Davey Smith, George, Reiner, Alex P, Talmud, Philippa J, Kivimäki, Mika, Lawlor, Debbie A, Dudbridge, Frank, Samani, Nilesh J, Keating, Brendan J, Hingorani, Aroon D, Casas, Juan P

Volltext

Molecular characterization of colorectal cancer related peritoneal metastatic disease von Lenos, Kristiaan J., Bach, Sander, Ferreira Moreno, Leandro, ten Hoorn, Sanne, Sluiter, Nina R., Bootsma, Sanne, Vieira Braga, Felipe A., Nijman, Lisanne E., van den Bosch, Tom, Miedema, Daniel M., van Dijk, Erik, Ylstra, Bauke, Kulicke, Ruth, Davis, Fred P., Stransky, Nicolas, Smolen, Gromoslaw A., Coebergh van den Braak, Robert R. J., IJzermans, Jan N. M., Martens, John W. M., Hallam, Sally, Beggs, Andrew D., Kops, Geert J. P. L., Lansu, Nico, Bastiaenen, Vivian P., Klaver, Charlotte E. L., Lecca, Maria C., El Makrini, Khalid, Elbers, Clara C., Dings, Mark P. G., van Noesel, Carel J. M., Kranenburg, Onno, Medema, Jan Paul, Koster, Jan, Koens, Lianne, Punt, Cornelis J. A., Tanis, Pieter J., de Hingh, Ignace H., Bijlsma, Maarten F., Tuynman, Jurriaan B., Vermeulen, Louis

Volltext

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections von Ferwerda, Gerben, Ferwerda, Bart, Plantinga, Theo S, Willment, Janet A, van Spriel, Annemiek B, Venselaar, Hanka, Elbers, Clara C, Johnson, Melissa D, Cambi, Alessandra, Huysamen, Cristal, Jacobs, Liesbeth, Jansen, Trees, Verheijen, Karlijn, Masthoff, Laury, Morré, Servaas A, Vriend, Gert, Williams, David L, Perfect, John R, Joosten, Leo A.B, Wijmenga, Cisca, van der Meer, Jos W.M, Adema, Gosse J, Kullberg, Bart Jan, Brown, Gordon D, Netea, Mihai G

Volltext

Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis von Holmes, Michael V., Lange, Leslie A., Palmer, Tom, Lanktree, Matthew B., North, Kari E., Almoguera, Berta, Buxbaum, Sarah, Chandrupatla, Hareesh R., Elbers, Clara C., Guo, Yiran, Hoogeveen, Ron C., Li, Jin, Li, Yun R., Swerdlow, Daniel I., Cushman, Mary, Price, Tom S., Curtis, Sean P., Fornage, Myriam, Hakonarson, Hakon, Patel, Sanjay R., Redline, Susan, Siscovick, David S., Tsai, Michael Y., Wilson, James G., van der Schouw, Yvonne T., FitzGerald, Garret A., Hingorani, Aroon D., Casas, Juan P., de Bakker, Paul I.W., Rich, Stephen S., Schadt, Eric E., Asselbergs, Folkert W., Reiner, Alex P., Keating, Brendan J.

Volltext

The Genome of the Netherlands: design, and project goals von Boomsma, Dorret I, Wijmenga, Cisca, Slagboom, Eline P, Swertz, Morris A, Karssen, Lennart C, Abdellaoui, Abdel, Ye, Kai, Guryev, Victor, Vermaat, Martijn, van Dijk, Freerk, Francioli, Laurent C, Hottenga, Jouke Jan, Laros, Jeroen F J, Li, Qibin, Li, Yingrui, Cao, Hongzhi, Chen, Ruoyan, Du, Yuanping, Li, Ning, Cao, Sujie, van Setten, Jessica, Menelaou, Androniki, Pulit, Sara L, Hehir-Kwa, Jayne Y, Beekman, Marian, Elbers, Clara C, Byelas, Heorhiy, de Craen, Anton J M, Deelen, Patrick, Dijkstra, Martijn, den Dunnen, Johan T, de Knijff, Peter, Houwing-Duistermaat, Jeanine, Koval, Vyacheslav, Estrada, Karol, Hofman, Albert, Kanterakis, Alexandros, Enckevort, David van, Mai, Hailiang, Kattenberg, Mathijs, van Leeuwen, Elisabeth M, Neerincx, Pieter B T, Oostra, Ben, Rivadeneira, Fernanodo, Suchiman, Eka H D, Uitterlinden, Andre G, Willemsen, Gonneke, Wolffenbuttel, Bruce H, Wang, Jun, de Bakker, Paul I W, van Ommen, Gert-Jan, van Duijn, Cornelia M

Volltext

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA von Fehrmann, Rudolf S N, Jansen, Ritsert C, Veldink, Jan H, Westra, Harm-Jan, Arends, Danny, Bonder, Marc Jan, Fu, Jingyuan, Deelen, Patrick, Groen, Harry J M, Smolonska, Asia, Weersma, Rinse K, Hofstra, Robert M W, Buurman, Wim A, Rensen, Sander, Wolfs, Marcel G M, Platteel, Mathieu, Zhernakova, Alexandra, Elbers, Clara C, Festen, Eleanora M, Trynka, Gosia, Hofker, Marten H, Saris, Christiaan G J, Ophoff, Roel A, van den Berg, Leonard H, van Heel, David A, Wijmenga, Cisca, Te Meerman, Gerard J, Franke, Lude

Volltext

Pleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels von NAISHI LI, VAN DER SIJDE, Marijke R, JINGYUAN FU, BAKKER, Stephan J. L, DULLAART, Robin P. F, VAN DER HARST, Pim, GANSEVOORT, Ron T, ELBERS, Clara C, WIJMENGA, Cisca, SNIEDER, Harold, HOFKER, Marten H

Volltext

The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial von Linssen, Jasmijn D G, van Neerven, Sanne M, Aelvoet, Arthur S, Elbers, Clara C, Vermeulen, Louis, Dekker, Evelien

Volltext

Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection von Zhernakova, Alexandra, Elbers, Clara C., Ferwerda, Bart, Romanos, Jihane, Trynka, Gosia, Dubois, Patrick C., de Kovel, Carolien G.F., Franke, Lude, Oosting, Marije, Barisani, Donatella, Bardella, Maria Teresa, Joosten, Leo A.B., Saavalainen, Paivi, van Heel, David A., Catassi, Carlo, Netea, Mihai G., Wijmenga, Cisca

Volltext

Intestinal Apc‐inactivation induces HSP25 dependency von van Neerven, Sanne M, Smit, Wouter L, van Driel, Milou S, Kakkar, Vaishali, de Groot, Nina E, Nijman, Lisanne E, Elbers, Clara C, Léveillé, Nicolas, Heijmans, Jarom, Vermeulen, Louis

Volltext

Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration[S] von Lanktree, Matthew B., Elbers, Clara C., Li, Yun, Zhang, Guosheng, Duan, Qing, Karczewski, Konrad J., Guo, Yiran, Tragante, Vinicius, North, Kari E., Cushman, Mary, Asselbergs, Folkert W., Wilson, James G., Lange, Leslie A., Drenos, Fotios, Reiner, Alex P., Barnes, Michael R., Keating, Brendan J.

Volltext

Whole-genome sequence variation, population structure and demographic history of the Dutch population von Francioli, Laurent C, Menelaou, Androniki, Pulit, Sara L, van Dijk, Feerk, Palamara, Pier Francesco, Elbers, Clara C, Neerincx, Pieter B T, Ye, Kai, Guryev, Victor, Kloosterman, Wigard P, Deelen, Patrick, Abdellaoui, Abdel, van Leeuwen, Elisabeth M, van Oven, Mannis, Vermaat, Martijn, Li, Mingkun, Laros, Jeroen F J, Karssen, Lennart C, Kanterakis, Alexandros, Amin, Najaf, Hottenga, Jouke Jan, Lameijer, Eric-Wubbo, Kattenberg, Mathijs, Dijkstra, Martijn, Byelas, Heorhiy, van Setten, Jessica, van Schaik, Barbera D C, Bot, Jan, Nijman, Isaäc J, Renkens, Ivo, Marschall, Tobias, Schönhuth, Alexander, Hehir-Kwa, Jayne Y, Handsaker, Robert E, Polak, Paz, Sohail, Mashaal, Vuzman, Dana, Hormozdiari, Fereydoun, van Enckevort, David, Mei, Hailiang, Koval, Vyacheslav, Moed, Matthijs H, van der Velde, K Joeri, Rivadeneira, Fernando, Estrada, Karol, Medina-Gomez, Carolina, Isaacs, Aaron, McCarroll, Steven A, Beekman, Marian, de Craen, Anton J M, Suchiman, H Eka D, Hofman, Albert, Oostra, Ben, Uitterlinden, André G, Willemsen, Gonneke, Platteel, Mathieu, Veldink, Jan H, van den Berg, Leonard H, Pitts, Steven J, Potluri, Shobha, Sundar, Purnima, Cox, David R, Sunyaev, Shamil R, den Dunnen, Johan T, Stoneking, Mark, de Knijff, Peter, Kayser, Manfred, Li, Qibin, Li, Yingrui, Du, Yuanping, Chen, Ruoyan, Cao, Hongzhi, Li, Ning, Cao, Sujie, Wang, Jun, Bovenberg, Jasper A, Pe'er, Itsik, Slagboom, P Eline, van Duijn, Cornelia M, Boomsma, Dorret I, van Ommen, Gert-Jan B, de Bakker, Paul I W, Swertz, Morris A, Wijmenga, Cisca

Volltext

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp von van Vliet-Ostaptchouk, Jana V, van Haeften, Timon W, Landman, Gijs W D, Reiling, Erwin, Kleefstra, Nanne, Bilo, Henk J G, Klungel, Olaf H, de Boer, Anthonius, van Diemen, Cleo C, Wijmenga, Cisca, Boezen, H Marike, Dekker, Jacqueline M, van 't Riet, Esther, Nijpels, Giel, Welschen, Laura M C, Zavrelova, Hata, Bruin, Elinda J, Elbers, Clara C, Bauer, Florianne, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Grobbee, Diederick E, Spijkerman, Annemieke M W, van der A, Daphne L, Simonis-Bik, Annemarie M, Eekhoff, Elisabeth M W, Diamant, Michaela, Kramer, Mark H H, Boomsma, Dorret I, de Geus, Eco J, Willemsen, Gonneke, Slagboom, P Eline, Hofker, Marten H, 't Hart, Leen M

Volltext

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans von MANGINO, Massimo, HWANG, Shih-Jen, WEI CHEN, SRINIVASAN, Sathanur R, KART, Jeremy D, BENETOS, Athanase, EL SHAMIEH, Said, VISVIKIS-SIEST, Sophie, CHRISTENSEN, Kaare, BERENSON, Gerald S, VALDES, Ana M, VINUELA, Ana, SPECTOR, Timothy D, GARCIA, Melissa, ARNETT, Donna K, BROECKEL, Ulrich, PROVINCE, Michael A, PANKOW, James S, KAMMERER, Candace, YONGMEI LIU, NALLS, Michael, TISHKOFF, Sarah, THOMAS, Fridtjof, HUNT, Steven C, ZIV, Elad, PSATY, Bruce M, BIS, Joshua C, ROTTER, Jerome I, TAYLOR, Kent D, SMITH, Erin, SCHORK, Nicholas J, LEVY, Daniel, AVIV, Abraham, KIMURA, Masayuki, FITZPATRICK, Annette L, CHRISTIANSEN, Lene, PETERSEN, Inge, ELBERS, Clara C, HARRIS, Tamara

Volltext

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference von Bauer, Florianne, Elbers, Clara C, Adan, Roger AH, Loos, Ruth JF, Onland-Moret, N. Charlotte, Grobbee, Diederick E, van Vliet-Ostaptchouk, Jana V, Wijmenga, Cisca, van der Schouw, Yvonne T

Volltext

Comparison between southern blots and qPCR analysis of leukocyte telomere length in the health ABC study von Elbers, Clara C, Garcia, Melissa E, Kimura, Masayuki, Cummings, Steven R, Nalls, Mike A, Newman, Anne B, Park, Vicki, Sanders, Jason L, Tranah, Gregory J, Tishkoff, Sarah A, Harris, Tamara B, Aviv, Abraham

Volltext

Using genome-wide pathway analysis to unravel the etiology of complex diseases von Elbers, Clara C., van Eijk, Kristel R., Franke, Lude, Mulder, Flip, van der Schouw, Yvonne T., Wijmenga, Cisca, Onland-Moret, N. Charlotte

Volltext

Negative selection in humans and fruit flies involves synergistic epistasis von Sohail, Mashaal, Vakhrusheva, Olga A., Sul, Jae Hoon, Pulit, Sara L., Francioli, Laurent C., van den Berg, Leonard H., Veldink, Jan H., de Bakker, Paul I. W., Bazykin, Georgii A., Kondrashov, Alexey S., Sunyaev, Shamil R.

Volltext

Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans von Elbers, Clara C, de Kovel, Carolien G F, van der Schouw, Yvonne T, Meijboom, Juliaan R, Bauer, Florianne, Grobbee, Diederick E, Trynka, Gosia, van Vliet-Ostaptchouk, Jana V, Wijmenga, Cisca, Onland-Moret, N Charlotte

Volltext