A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current von Yang, Pei-Chi, Ph.D, El-Bizri, Nesrine, Ph.D, Romero, Lucia, Ph.D, Giles, Wayne R., Ph.D, Rajamani, Sridharan, Ph.D, Belardinelli, Luiz, M.D, Clancy, Colleen E., Ph.D

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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension von Spiekerkoetter, Edda, Tian, Xuefei, Cai, Jie, Hopper, Rachel K, Sudheendra, Deepti, Li, Caiyun G, El-Bizri, Nesrine, Sawada, Hirofumi, Haghighat, Roxanna, Chan, Roshelle, Haghighat, Leila, de Jesus Perez, Vinicio, Wang, Lingli, Reddy, Sushma, Zhao, Mingming, Bernstein, Daniel, Solow-Cordero, David E, Beachy, Philip A, Wandless, Thomas J, Ten Dijke, Peter, Rabinovitch, Marlene

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A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias von Belardinelli, Luiz, Liu, Gongxin, Smith-Maxwell, Cathy, Wang, Wei-Qun, El-Bizri, Nesrine, Hirakawa, Ryoko, Karpinski, Serge, Li, Cindy Hong, Hu, Lufei, Li, Xiao-Jun, Crumb, William, Wu, Lin, Koltun, Dmitry, Zablocki, Jeff, Yao, Lina, Dhalla, Arvinder K, Rajamani, Sridharan, Shryock, John C

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The novel late Na+ current inhibitor, GS‐6615 (eleclazine) and its anti‐arrhythmic effects in rabbit isolated heart preparations von Rajamani, Sridharan, Liu, Gongxin, El‐Bizri, Nesrine, Guo, Donglin, Li, Cindy, Chen, Xiao‐Liang, Kahlig, Kristopher M, Mollova, Nevena, Elzein, Elfatih, Zablocki, Jeff, Belardinelli, Luiz

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Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models von Hou, Luqia, Kumar, Mohit, Anand, Priti, Chen, Yinhong, El-Bizri, Nesrine, Pickens, Chad J., Seganish, W. Michael, Sadayappan, Sakthivel, Swaminath, Gayathri

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Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes von Viatchenko-Karpinski, Serge, Kornyeyev, Dmytro, El-Bizri, Nesrine, Budas, Grant, Fan, Peidong, Jiang, Zhan, Yang, Jin, Anderson, Mark E., Shryock, John C., Chang, Ching-Pin, Belardinelli, Luiz, Yao, Lina

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Use-dependent block of cardiac late Na+ current by ranolazine von Rajamani, Sridharan, PhD, El-Bizri, Nesrine, PhD, Shryock, John C., PhD, Makielski, Jonathan C., MD, Belardinelli, Luiz, MD

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Ranolazine block of human Nav1.4 sodium channels and paramyotonia congenita mutants von El-Bizri, Nesrine, Kahlig, Kristopher M., Shyrock, John C., George, Jr, Alfred L., Belardinelli, Luiz, Rajamani, Sridharan

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Eleclazine exhibits enhanced selectivity for long QT syndrome type 3–associated late Na+ current von El-Bizri, Nesrine, Xie, Cheng, Liu, Lynda, Limberis, James, Krause, Michael, Hirakawa, Ryoko, Nguyen, Steven, Tabuena, Dennis R., Belardinelli, Luiz, Kahlig, Kristopher M.

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Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension von Wang, Lingli, Moonen, Jan-Renier, Cao, Aiqin, Isobe, Sarasa, Li, Caiyun G., Tojais, Nancy F., Taylor, Shalina, Marciano, David P., Chen, Pin-I., Gu, Mingxia, Li, Dan, Harper, Rebecca L., El-Bizri, Nesrine, Kim, Yu-Mee, Stankunas, Kryn, Rabinovitch, Marlene

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Selective inhibition of physiological late Na + current stabilizes ventricular repolarization von El-Bizri, Nesrine, Li, Cindy Hong, Liu, Gong-Xin, Rajamani, Sridharan, Belardinelli, Luiz

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Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension von Wang, Lingli, Moonen, Jan Renier, Cao, Aiqin, Isobe, Sarasa, Li, Caiyun G., Tojais, Nancy F., Taylor, Shalina, Marciano, David P., Chen, Pin-I., Gu, Mingxia, Li, Dan, Harper, Rebecca L., El-Bizri, Nesrine, Kim, YuMee, Stankunas, Kryn, Rabinovitch, Marlene

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Abstract 13402: FHL-1 Contributes to and Colocalizes With Titin in Cardiac Hypertrophy von El-Bizri, Nesrine, Liu, Jing, Matt, Rachel, Iyer, Rugmani P, Raman, Girija, Tanis, Keith Q, Zhou, Heather, Rosahl, Thomas W, Sheth, Payal, Swaminath, Gayathri

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Abstract 17193: Inhibiting Late Sodium Current Attenuates Isoproterenol-Induced Transient Inward Current and Delayed Afterdepolarizations in Ventricular Myocytes von Song, Yejia, El-Bizri, Nesrine, Rajamani, Sridharan, Belardinelli, Luiz

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Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin von Kornyeyev, Dmytro, El-Bizri, Nesrine, Hirakawa, Ryoko, Nguyen, Steven, Viatchenko-Karpinski, Serge, Yao, Lina, Rajamani, Sridharan, Belardinelli, Luiz

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties von Zablocki, Jeff A, Elzein, Elfatih, Li, Xiaofen, Koltun, Dmitry O, Parkhill, Eric Q, Kobayashi, Tetsuya, Martinez, Ruben, Corkey, Britton, Jiang, Haibo, Perry, Thao, Kalla, Rao, Notte, Gregory T, Saunders, Oliver, Graupe, Michael, Lu, Yafan, Venkataramani, Chandru, Guerrero, Juan, Perry, Jason, Osier, Mark, Strickley, Robert, Liu, Gongxin, Wang, Wei-Qun, Hu, Lufei, Li, Xiao-Jun, El-Bizri, Nesrine, Hirakawa, Ryoko, Kahlig, Kris, Xie, Cheng, Li, Cindy Hong, Dhalla, Arvinder K, Rajamani, Sridharan, Mollova, Nevena, Soohoo, Daniel, Lepist, Eve-Irene, Murray, Bernard, Rhodes, Gerry, Belardinelli, Luiz, Desai, Manoj C

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Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine von Hirakawa, Ryoko, El-Bizri, Nesrine, Shryock, John C., Belardinelli, Luiz, Rajamani, Sridharan

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The novel late Na super(+) current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations von Rajamani, Sridharan, Liu, Gongxin, El-Bizri, Nesrine, Guo, Donglin, Li, Cindy, Chen, Xiao-Liang, Kahlig, Kristopher M, Mollova, Nevena, Elzein, Elfatih, Zablocki, Jeff, Belardinelli, Luiz

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Post-junctional mechanisms involved in the potentiation of cardiac adrenergic responses by cocaine von Sabra, Ramzi, Khoury, Hadi A, Bechara, Grace, Sharaf, Laila H, El-Bizri, Nesrine M

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Selective Inhibition of Late Na+ Current Reduces Arrhythmic Activity in Spontaneously Hypertensive Rat Myocytes von El-Bizri, Nesrine, Nguyen, Steven, Liu, Gongxin, Belardinelli, Luiz, Rajamani, Sridharan

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