Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms von Eißmann, M, Melzer, I M, Fernández, S B M, Michel, G, Hrabě de Angelis, M, Hoefler, G, Finkenwirth, P, Jauch, A, Schoell, B, Grez, M, Schmidt, M, Bartholomae, C C, Newrzela, S, Haetscher, N, Rieger, M A, Zachskorn, C, Mittelbronn, M, Zörnig, M

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Interleukin 33: A new target against gastrointestinal cancer? von Eissmann, M., Dijkstra, C., Ernst, M.

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Restricted STAT3 inhibition among tumour infiltrating immune cells restricts colorectal tumour growth von Alorro, M., Eissmann, M., Masson, F., Ernst, M.

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DNA methyltransferases drive gastric cancer growth and present a therapy target for gastric cancer von Huber, A., Dijkstra, C., Ernst, M., Eissmann, M.

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Disproportionate mitral regurgitation as a predictor of functional outcomes following edge-to-edge repair with the MitraClip system von Maltsinioti Charalampia, C M, Schueler Robert, R S, Lambers Moritz, M L, Eissmann Mareike, M E, Schmitz Thomas, T S, Bruder Oliver, O B

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Low Incidence of Paravalvular Leakage With the Balloon-Expandable Sapien 3 Transcatheter Heart Valve von Wendt, Daniel, MD, Al-Rashid, Fadi, MD, Kahlert, Philipp, MD, Eißmann, Mareike, MD, El-Chilali, Karim, MD, Jánosi, Rolf Alexander, MD, Pasa, Susanne, MD, Tsagakis, Konstantinos, MD, Liakopoulos, Oliver, MD, Erbel, Raimund, MD, Jakob, Heinz, MD, Thielmann, Matthias, MD

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Case-based session: unusual and multitrouble cases: Saturday 6 December 2014, 08:30-10:0 Location: Agora von Eissmann, M., Kahlert, P., Erbel, R., Janosi, R., Soeholm, H., Hassager, C., Vejlstrup, N., Arendrup, H., Jensen, M., Lund, J., Ihlemann, N., Neykova, A., Molcard, D., Moulla, M., Valizadeh, R., Alghandour, M., Mahmoud, M., Shimbo, M., Watanabe, H., Iino, K., Ito, H., Piriou, N., Sassier, J., Pallardy, A., Valette, F., Serfaty, J., Trochu, J., Cordovil, A., Tude Rodrigues, A., Piveta, R., De Oliveira, W., Ponchirolli, A., Monaco, C., De Lira Filho, E., Vieira, M., Fischer, C., Morhy, S.

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A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development von O’Keefe, Ryan N., Carli, Annalisa L. E., Baloyan, David, Chisanga, David, Shi, Wei, Afshar-Sterle, Shoukat, Eissmann, Moritz F., Poh, Ashleigh R., Pal, Bhupinder, Seillet, Cyril, Locksley, Richard M., Ernst, Matthias, Buchert, Michael

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Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells von Chauveau, Anne, Aucher, Anne, Eissmann, Philipp, Vivier, Eric, Davis, Daniel M

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Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission von Davis, Daniel M, Sowinski, Stefanie, Brodsky, Frances M, Jolly, Clare, Purbhoo, Marco A, Köhler, Karsten, Eissmann, Philipp, Hopkins, Colin, Chauveau, Anne, Önfelt, Björn, Berninghausen, Otto, Oddos, Stephane, Sattentau, Quentin

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Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-γ-Dependent Manner von Eissmann, Moritz F, Dijkstra, Christine, Wouters, Merridee A, Baloyan, David, Mouradov, Dmitri, Nguyen, Paul M, Davalos-Salas, Mercedes, Putoczki, Tracy L, Sieber, Oliver M, Mariadason, John M, Ernst, Matthias, Masson, Frederick

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EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc -initiated colonic tumorigenesis von Reehorst, Camilla M., Nightingale, Rebecca, Luk, Ian Y., Jenkins, Laura, Koentgen, Frank, Williams, David S., Darido, Charbel, Tan, Fiona, Anderton, Holly, Chopin, Michael, Schoffer, Kael, Eissmann, Moritz F., Buchert, Michael, Mouradov, Dmitri, Sieber, Oliver M., Ernst, Matthias, Dhillon, Amardeep S., Mariadason, John M.

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Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy von Brown, Alice C N, Oddos, Stephane, Dobbie, Ian M, Alakoskela, Juha-Matti, Parton, Richard M, Eissmann, Philipp, Neil, Mark A A, Dunsby, Christopher, French, Paul M W, Davis, Ilan, Davis, Daniel M

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DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression von Afshar-Sterle, Shoukat, Carli, Annalisa L E, O'Keefe, Ryan, Tse, Janson, Fischer, Stefanie, Azimpour, Alexander I, Baloyan, David, Elias, Lena, Thilakasiri, Pathum, Patel, Onisha, Ferguson, Fleur M, Eissmann, Moritz F, Chand, Ashwini L, Gray, Nathanael S, Busuttil, Rita, Boussioutas, Alex, Lucet, Isabelle S, Ernst, Matthias, Buchert, Michael

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Epithelial gp130/Stat3 functions: An intestinal signaling node in health and disease von Ernst, Matthias, Thiem, Stefan, Nguyen, Paul M, Eissmann, Moritz, Putoczki, Tracy L

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Mitral Valve Transcatheter Edge-to-Edge Repair: 1-Year Outcomes From the MiCLASP Study von Lurz, Philipp, Schmitz, Thomas, Geisler, Tobias, Hausleiter, Jörg, Eitel, Ingo, Rudolph, Volker, Lubos, Edith, von Bardeleben, Ralph Stephan, Brambilla, Nedy, De Marco, Federico, Berti, Sergio, Nef, Holger, Linke, Axel, Hengstenberg, Christian, Baldus, Stephan, Spargias, Konstantinos, Denti, Paolo, Nickenig, Georg, Möllmann, Helge, Rottbauer, Wolfgang, Praz, Fabien, Butter, Christian, Reinthaler, Markus, Van Mieghem, Nicolas M, Sherif, Mohammad, Swaans, Martin, Witkowski, Adam, Buch, Mamta, Seidler, Tim, Iñiguez, Andrés, Thiele, Holger, Eißmann, Mareike, Schreieck, Juergen, Näbauer, Michael, Marcoff, Leo, Koulogiannis, Konstantinos, Rassaf, Tienush, Luedike, Peter

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Multiple mechanisms downstream of TLR-4 stimulation allow expression of NKG2D ligands to facilitate macrophage/NK cell crosstalk von Eissmann, Philipp, Evans, J Henry, Mehrabi, Maryam, Rose, Emma L, Nedvetzki, Shlomo, Davis, Daniel M

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Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells von Köhler, Karsten, Xiong, Shiqiu, Brzostek, Joanna, Mehrabi, Maryam, Eissmann, Philipp, Harrison, Alice, Cordoba, Shaun-Paul, Oddos, Stephane, Miloserdov, Vladimir, Gould, Keith, Burroughs, Nigel J, van der Merwe, Philip Anton, Davis, Daniel M

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Mitral Valve Transcatheter Edge-to-Edge Repair von Lurz, Philipp, Schmitz, Thomas, Geisler, Tobias, Hausleiter, Jörg, Eitel, Ingo, Rudolph, Volker, Lubos, Edith, von Bardeleben, Ralph Stephan, Brambilla, Nedy, De Marco, Federico, Berti, Sergio, Nef, Holger, Linke, Axel, Hengstenberg, Christian, Baldus, Stephan, Spargias, Konstantinos, Denti, Paolo, Nickenig, Georg, Möllmann, Helge, Rottbauer, Wolfgang, Praz, Fabien, Butter, Christian, Reinthaler, Markus, Van Mieghem, Nicolas M., Sherif, Mohammad, Swaans, Martin, Witkowski, Adam, Buch, Mamta, Seidler, Tim, Iñiguez, Andrés, Thiele, Holger, Eißmann, Mareike, Schreieck, Juergen, Näbauer, Michael, Marcoff, Leo, Koulogiannis, Konstantinos, Rassaf, Tienush, Luedike, Peter

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PS1163 PATIENT‐BASED PROSPECTIVE REAL WORLD DATA ANALYSIS SHOWS THAT THE DURATION OF TREATMENT INTERRUPTIONS WITH SUBSEQUENT RESUMPTION OF IDELALISIB THERAPY CAN VARY FROM DAYS TO... von Hoechstetter, M., Knauf, W., Eissmann, P., Hucke, N., Ramroth, H., Abenhardt, W., Rummel, M.

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