Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Zeng, Xin, Montoute, Monica N, Chordia, Tushar, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Haile, Pamela A, Yu, Jong, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity von Charnley, Adam K., Convery, Máire A., Lakdawala Shah, Ami, Jones, Emma, Hardwicke, Philip, Bridges, Angela, Ouellette, Michael, Totoritis, Rachel, Schwartz, Benjamin, King, Bryan W., Wisnoski, David D., Kang, James, Eidam, Patrick M., Votta, Bartholomew J., Gough, Peter J., Marquis, Robert W., Bertin, John, Casillas, Linda

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(R)- and (S)-4-TIPS-3-butyn-2-ol. Useful Precursors of Chiral Allenylzinc and Indium Reagents von Marshall, James A, Eidam, Patrick, Eidam, Hilary Schenck

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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer von Harris, Philip A, Marinis, Jill M, Lich, John D, Berger, Scott B, Chirala, Anirudh, Cox, Julie A, Eidam, Patrick M, Finger, Joshua N, Gough, Peter J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Leister, Lara K, Mahajan, Mukesh K, Miller, George, Nagilla, Rakesh, Ouellette, Michael T, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Sun, Helen H, Thorpe, James H, Totoritis, Rachel D, Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W

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A Formal Synthesis of the Callipeltoside Aglycone von Marshall, James A, Eidam, Patrick M

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Palladium- and Copper-Catalyzed 1,4-Additions of Organozinc Compounds to Conjugated Aldehydes von Marshall, James A, Herold, Martin, Eidam, Hilary S, Eidam, Patrick

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The BlueScreen-384 Assay as an Indicator of Genotoxic Hazard Potential in Early-Stage Drug Discovery von Simpson, Kate, Bevan, Nicola, Hastwell, Paul, Eidam, Patrick, Shah, Poonam, Gogo, Elke, Rees, Steve, Brown, Andrew

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Hybrid Gasoline Production from Black Liquor through Coprocessing von Melin, Kristian, Strüven, Jan Ole, Eidam, Patrick, Appelt, Jörn, Hummel, Christin, Armbruster, Udo, Chapellière, Yann, Mirodatos, Claude, Schuurman, Yves, Oasmaa, Anja

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase von Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W

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Diastereoselective Additions of Chiral Vinylzinc Reagents to α-Chiral Aldehydes von Marshall, James A, Eidam, Patrick

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Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Zeng, Xin, Montoute, Monica N, Chordia, Tushar, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Haile, Pamela A, Yu, Jong, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

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Structure–activity relationship studies of novel 3-oxazolidinedione-6-naphthyl-2-pyridinones as potent and orally bioavailable EP₃ receptor antagonists von Morales-Ramos, Ángel I, Li, Yue H, Hilfiker, Mark, Mecom, John S, Eidam, Patrick, Shi, Dongchuan, Tseng, Pei-San, Brooks, Carl, Zhang, David, Wang, Ning, Jaworski, Jon-Paul, Morrow, Dwight, Fries, Harvey, Edwards, Richard, Jin, Jian

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Structure-activity relationship studies of novel 3-oxazolidinedione-6-naphthyl-2-pyridinones as potent and orally bioavailable EP sub(3 receptor antagonists) von Morales-Ramos, Angel I, Li, Yue H, Hilfiker, Mark, Mecom, John S, Eidam, Patrick, Shi, Dongchuan, Tseng, Pei-San, Brooks, Carl, Zhang, David, Wang, Ning, Jaworski, Jon-Paul, Morrow, Dwight, Fries, Harvey, Edwards, Richard, Jin, Jian

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Structure–activity relationship studies of novel 3-oxazolidinedione-6-naphthyl-2-pyridinones as potent and orally bioavailable EP 3 receptor antagonists von Morales-Ramos, Ángel I., Li, Yue H., Hilfiker, Mark, Mecom, John S., Eidam, Patrick, Shi, Dongchuan, Tseng, Pei-San, Brooks, Carl, Zhang, David, Wang, Ning, Jaworski, Jon-Paul, Morrow, Dwight, Fries, Harvey, Edwards, Richard, Jin, Jian

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SYNTHESIS OF 4-TRIISOPROPYLSILYL-3-BUTYN-2-OL BY ASYMMETRIC TRANSFER HYDROGENATION

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Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists von Jin, Jian, Morales-Ramos, Ángel, Eidam, Patrick, Mecom, John, Li, Yue, Brooks, Carl, Hilfiker, Mark, Zhang, David, Wang, Ning, Shi, Dongchuan, Tseng, Pei-San, Wheless, Karen, Budzik, Brian, Evans, Karen, Jaworski, Jon-Paul, Jugus, Jack, Leon, Lisa, Wu, Charlene, Pullen, Mark, Karamshi, Bhumika, Rao, Parvathi, Ward, Emma, Laping, Nicholas, Evans, Christopher, Leach, Colin, Holt, Dennis, Su, Xin, Morrow, Dwight, Fries, Harvey, Thorneloe, Kevin, Edwards, Richard

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Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP 3 Receptor Antagonists von Jin, Jian, Morales-Ramos, Ángel, Eidam, Patrick, Mecom, John, Li, Yue, Brooks, Carl, Hilfiker, Mark, Zhang, David, Wang, Ning, Shi, Dongchuan, Tseng, Pei-San, Wheless, Karen, Budzik, Brian, Evans, Karen, Jaworski, Jon-Paul, Jugus, Jack, Leon, Lisa, Wu, Charlene, Pullen, Mark, Karamshi, Bhumika, Rao, Parvathi, Ward, Emma, Laping, Nicholas, Evans, Christopher, Leach, Colin, Holt, Dennis, Su, Xin, Morrow, Dwight, Fries, Harvey, Thorneloe, Kevin, Edwards, Richard

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Heterocyclic amides as kinase inhibitors von Sehon, Clark A, Daugan, Alain Claude-Marie, Harris, Philip Anthony, White, Gemma Victoria, Eidam, Patrick M, Anderson, Niall Andrew, Bandyopadhyay, Deepak, Donche, Frederic G, George, Nicolas S, King, Bryan W, Jeong, Jae U, Faucher, Nicolas Eric, Wisnoski, David Duff

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