High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits von Schiebel, Johannes, Krimmer, Stefan G., Röwer, Karine, Knörlein, Anna, Wang, Xiaojie, Park, Ah Young, Stieler, Martin, Ehrmann, Frederik R., Fu, Kan, Radeva, Nedyalka, Krug, Michael, Huschmann, Franziska U., Glöckner, Steffen, Weiss, Manfred S., Mueller, Uwe, Klebe, Gerhard, Heine, Andreas

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Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT) von Barandun, Luzi J., Ehrmann, Frederik R., Zimmerli, Daniel, Immekus, Florian, Giroud, Maude, Grünenfelder, Claudio, Schweizer, W. Bernd, Bernet, Bruno, Betz, Michael, Heine, Andreas, Klebe, Gerhard, Diederich, François

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Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study von Schiebel, Johannes, Radeva, Nedyalka, Krimmer, Stefan G, Wang, Xiaojie, Stieler, Martin, Ehrmann, Frederik R, Fu, Kan, Metz, Alexander, Huschmann, Franziska U, Weiss, Manfred S, Mueller, Uwe, Heine, Andreas, Klebe, Gerhard

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Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent‐Exposed Ribose‐33 Pocket of tRNA‐Guanine Transglycosylase von Movsisyan, Levon D., Schäfer, Elisabeth, Nguyen, Andreas, Ehrmann, Frederik R., Schwab, Anatol, Rossolini, Thomas, Zimmerli, Daniel, Wagner, Björn, Daff, Hamina, Heine, Andreas, Klebe, Gerhard, Diederich, François

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Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT von Hassaan, Engi, Hohn, Christoph, Ehrmann, Frederik R, Goetzke, F. Wieland, Movsisyan, Levon, Hüfner-Wulsdorf, Tobias, Sebastiani, Maurice, Härtsch, Adrian, Reuter, Klaus, Diederich, François, Klebe, Gerhard

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A False‐Positive Screening Hit in Fragment‐Based Lead Discovery: Watch out for the Red Herring von Cramer, Jonathan, Schiebel, Johannes, Wulsdorf, Tobias, Grohe, Kristof, Najbauer, Eszter Eva, Ehrmann, Frederik R., Radeva, Nedyalka, Zitzer, Nina, Linne, Uwe, Linser, Rasmus, Heine, Andreas, Klebe, Gerhard

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Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad von Radeva, Nedyalka, Schiebel, Johannes, Wang, Xiaojie, Krimmer, Stefan G, Fu, Kan, Stieler, Martin, Ehrmann, Frederik R, Metz, Alexander, Rickmeyer, Thomas, Betz, Michael, Winquist, Johan, Park, Ah Young, Huschmann, Franziska U, Weiss, Manfred S, Mueller, Uwe, Heine, Andreas, Klebe, Gerhard

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Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin von Radeva, Nedyalka, Krimmer, Stefan G, Stieler, Martin, Fu, Kan, Wang, Xiaojie, Ehrmann, Frederik R, Metz, Alexander, Huschmann, Franziska U, Weiss, Manfred S, Mueller, Uwe, Schiebel, Johannes, Heine, Andreas, Klebe, Gerhard

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Frontispiece: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT) von Barandun, Luzi J., Ehrmann, Frederik R., Zimmerli, Daniel, Immekus, Florian, Giroud, Maude, Grünenfelder, Claudio, Schweizer, W. Bernd, Bernet, Bruno, Betz, Michael, Heine, Andreas, Klebe, Gerhard, Diederich, François

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Falsch‐positiver Treffer im Fragment‐basierten Wirkstoffdesign: Lass Dich nicht auf die falsche Fährte locken von Cramer, Jonathan, Schiebel, Johannes, Wulsdorf, Tobias, Grohe, Kristof, Najbauer, Eszter Eva, Ehrmann, Frederik R., Radeva, Nedyalka, Zitzer, Nina, Linne, Uwe, Linser, Rasmus, Heine, Andreas, Klebe, Gerhard

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Falsch-positiver Treffer im Fragment-basierten Wirkstoffdesign: Lass Dich nicht auf die falsche Fährte locken von Cramer, Jonathan, Schiebel, Johannes, Wulsdorf, Tobias, Grohe, Kristof, Najbauer, Eszter Eva, Ehrmann, Frederik R, Radeva, Nedyalka, Zitzer, Nina, Linne, Uwe, Linser, Rasmus, Heine, Andreas, Klebe, Gerhard

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