Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases von Ehm, Patrick A.H., Linnebacher, Michael, Block, Andreas, Rehbach, Christoph, Jücker, Manfred

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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway von Ehm, Patrick A H, Horn, Stefan, Hoffer, Konstantin, Kriegs, Malte, Horn, Michael, Giehler, Susanne, Nalaskowski, Marcus, Rehbach, Christoph, Horstmann, Martin A, Jücker, Manfred

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Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins von Ehm, Patrick A.H., Lange, Fabiola, Hentschel, Carolin, Jepsen, Anneke, Glück, Madeleine, Nelson, Nina, Bettin, Bettina, de Bruyn Kops, Christina, Kirchmair, Johannes, Nalaskowski, Marcus, Jücker, Manfred

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Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects von Wellbrock, Jasmin, Latuske, Emily, Köhler, Julian, Wagner, Katharina, Stamm, Hauke, Vettorazzi, Eik, Vohwinkel, Gabi, Klokow, Marianne, Uibeleisen, Roswitha, Ehm, Patrick, Riecken, Kristoffer, Loges, Sonja, Thol, Felicitas, Schubert, Claudia, Amling, Michael, Jücker, Manfred, Bokemeyer, Carsten, Heuser, Michael, Krauter, Jürgen, Fiedler, Walter

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SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model von Ehm, Patrick, Rietow, Ruth, Wegner, Wiebke, Bußmann, Lara, Kriegs, Malte, Dierck, Kevin, Horn, Stefan, Streichert, Thomas, Horstmann, Martin, Jücker, Manfred

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The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies von Ehm, Patrick, Nalaskowski, Marcus M, Wundenberg, Torsten, Jücker, Manfred

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Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer von Schaks, Matthias, Allgoewer, Kristina, Nelson, Nina, Ehm, Patrick, Heumann, Asmus, Ewald, Florian, Schumacher, Udo, Simon, Ronald, Sauter, Guido, Juecker, Manfred

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Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021 von Ehm, Patrick, Bettin, Bettina, Jücker, Manfred

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Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL) von Ehm, Patrick, Grottke, Astrid, Bettin, Bettina, Jücker, Manfred

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JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative Neoplasm (MPN) von Glück, Madeleine, Dally, Lina, Jücker, Manfred, Ehm, Patrick

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Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants von Ehm, Patrick, Nelson, Nina, Giehler, Susanne, Schaks, Matthias, Bettin, Bettina, Kirchmair, Johannes, Jücker, Manfred

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Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells von Nalaskowski, Marcus M., Ehm, Patrick, Rehbach, Christoph, Nelson, Nina, Täger, Maike, Modest, Kathrin, Jücker, Manfred

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Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins von Ehm, Patrick, Lange, Faabiola, Hentschel, Carolin, Jepsen, Anneke, Glück, Madeleine, Nelson, Nina, Bettin, Bettina, de Bruyn Kops, Christina, Kirchmair, Johannes, Nalaskowski, Marcus, Jücker, Manfred

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Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase von Kublun, Inga, Ehm, Patrick, Brehm, Maria A., Nalaskowski, Marcus M.

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A toolkit for graded expression of green fluorescent protein fusion proteins in mammalian cells von Nalaskowski, Marcus M., Ehm, Patrick, Giehler, Susanne, Mayr, Georg W.

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Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation von Meyer, Rüdiger, Nalaskowski, Marcus M., Ehm, Patrick, Schröder, Constantin, Naj, Xenia, Brehm, Maria A., Mayr, Georg W.

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Additional file 2 of Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway von Ehm, Patrick A. H., Horn, Stefan, Hoffer, Konstantin, Kriegs, Malte, Horn, Michael, Giehler, Susanne, Nalaskowski, Marcus, Rehbach, Christoph, Horstmann, Martin A., Jücker, Manfred

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Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins von Ehm, Patrick, Lange, Faabiola, Hentschel, Carolin, Jepsen, Anneke, Glück, Madeleine, Nelson, Nina, Bettin, Bettina, de Bruyn Kops, Christina, Kirchmair, Johannes, Nalaskowski, Marcus, Jücker, Manfred

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Transformation of semantic knowledge into simulation-based decision support von Jurasky, Wiking, Moder, Patrick, Milde, Michael, Ehm, Hans, Reinhart, Gunther

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The role of polygenic risk and susceptibility genes in breast cancer over the course of life von Mars, Nina, Widén, Elisabeth, Kerminen, Sini, Meretoja, Tuomo, Pirinen, Matti, della Briotta Parolo, Pietro, Palta, Priit, Palotie, Aarno, Kaprio, Jaakko, Joensuu, Heikki, Daly, Mark, Ripatti, Samuli

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