Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 von Pitrez, Patricia R., Estronca, Luís, Monteiro, Luís Miguel, Colell, Guillem, Vazão, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire, Egesipe, Anne-Laure, Carvalho, Tânia, Dos Santos, Rodrigo L., Lévy, Nicolas, Smith, James C., de Magalhães, João Pedro, Ori, Alessandro, Bernardo, Andreia, De Sandre-Giovannoli, Annachiara, Nissan, Xavier, Rosell, Anna, Ferreira, Lino

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Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD von Afroz, Tariq, Chevalier, Elodie, Audrain, Mickael, Dumayne, Christopher, Ziehm, Tamar, Moser, Roger, Egesipe, Anne-Laure, Mottier, Lorène, Ratnam, Monisha, Neumann, Manuela, Havas, Daniel, Ollier, Romain, Piorkowska, Kasia, Chauhan, Mayank, Silva, Alberto B., Thapa, Samjhana, Stöhr, Jan, Bavdek, Andrej, Eligert, Valerie, Adolfsson, Oskar, Nelson, Peter T., Porta, Sílvia, Lee, Virginia M.-Y., Pfeifer, Andrea, Kosco-Vilbois, Marie, Seredenina, Tamara

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Systems toxicology study reveals reduced impact of heated tobacco product aerosol extract relative to cigarette smoke on premature aging and exacerbation effects in aged aortic cel... von Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter K., Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

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Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework von Ollier, Romain, Fuchs, Aline, Gauye, Florence, Piorkowska, Katarzyna, Menant, Sébastien, Ratnam, Monisha, Montanari, Paolo, Guilhot, Florence, Phillipe, Didier, Audrain, Mickael, Egesipe, Anne-Laure, Névoltris, Damien, Seredenina, Tamara, Pfeifer, Andrea, Kosco-Vilbois, Marie, Afroz, Tariq

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Induced Pluripotent Stem Cells Reveal Functional Differences Between Drugs Currently Investigated in Patients With Hutchinson‐Gilford Progeria Syndrome von Blondel, Sophie, Jaskowiak, Anne-Laure, Egesipe, Anne-Laure, Le Corf, Amelie, Navarro, Claire, Cordette, Véronique, Martinat, Cécile, Laabi, Yacine, Djabali, Karima, de Sandre-Giovannoli, Annachiara, Levy, Nicolas, Peschanski, Marc, Nissan, Xavier

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Cytostatic Effect of Repeated Exposure to Simvastatin: A Mechanism for Chronic Myotoxicity Revealed by the Use of Mesodermal Progenitors Derived from Human Pluripotent Stem Cells von Peric, Delphine, Barragan, Isabel, Giraud‐Triboult, Karine, Egesipe, Anne‐Laure, Meyniel‐Schicklin, Laurène, Cousin, Christelle, Lotteau, Vincent, Petit, Vincent, Touhami, Jawida, Battini, Jean‐Luc, Sitbon, Marc, Pinset, Christian, Ingelman‐Sundberg, Magnus, Laustriat, Delphine, Peschanski, Marc

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A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells von Lo Cicero, Alessandra, Jaskowiak, Anne-Laure, Egesipe, Anne-Laure, Tournois, Johana, Brinon, Benjamin, Pitrez, Patricia R., Ferreira, Lino, de Sandre-Giovannoli, Annachiara, Levy, Nicolas, Nissan, Xavier

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Pathological modelling of pigmentation disorders associated with Hutchinson-Gilford Progeria Syndrome (HGPS) revealed an impaired melanogenesis pathway in iPS-derived melanocytes von Lo Cicero, Alessandra, Saidani, Manoubia, Allouche, Jennifer, Egesipe, Anne Laure, Hoch, Lucile, Bruge, Celine, Sigaudy, Sabine, De Sandre-Giovannoli, Annachiara, Levy, Nicolas, Baldeschi, Christine, Nissan, Xavier

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Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF von Audrain, Mickael, Egesipe, Anne-Laure, Tentillier, Noémie, Font, Laure, Ratnam, Monisha, Mottier, Lorene, Clavel, Mathieu, Le Roux-Bourdieu, Morgan, Fenyi, Alexis, Ollier, Romain, Chevalier, Elodie, Guilhot, Florence, Fuchs, Aline, Piorkowska, Kasia, Carlyle, Becky, Arnold, Steven E, Berry, James D, Luthi-Carter, Ruth, Adolfsson, Oskar, Pfeifer, Andrea, Kosco-Vilbois, Marie, Seredenina, Tamara, Afroz, Tariq

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Substrate Topography Modulates Cell Aging on a Progeria Cell Model von Pitrez, Patricia R, Estronca, Luís, Vazão, Helena, Egesipe, Anne-Laure, Le Corf, Amélie, Navarro, Claire, Lévy, Nicolas, De Sandre-Giovannoli, Annachiara, Nissan, Xavier, Ferreira, Lino

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Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells von Egesipe, Anne-Laure, Blondel, Sophie, Lo Cicero, Alessandra, Jaskowiak, Anne-Laure, Navarro, Claire, Sandre-Giovannoli, Annachiara De, Levy, Nicolas, Peschanski, Marc, Nissan, Xavier

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VULNERABILITY OF PROGEROID SMOOTH MUSCLE CELLS TO ARTERIAL SHEAR STRESS IS MEDIATED BY MMP13 von Pitrez, Patricia, Estronca, Luis, Monteiro, Luis, Colell, Guillem, Vazão, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire L., Egesipe, Anne-Laure, Cavalho, Tania, dos Santos, Rodrigo L, Levy, Nicolas, Smith, James, Magalhaes, Joao-Pedro, Ori, Alessandro, Bernardo, Andreia, de Sandre-Giovannoli, Annachiara, Nissan, Xavier, Rosell, Anna, Ferreira, Lino

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Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation von Blondel, S, Egesipe, A-L, Picardi, P, Jaskowiak, A-L, Notarnicola, M, Ragot, J, Tournois, J, Le Corf, A, Brinon, B, Poydenot, P, Georges, P, Navarro, C, pitrez, P R, Ferreira, L, Bollot, G, Bauvais, C, Laustriat, D, Mejat, A, De Sandre-Giovannoli, A, Levy, N, Bifulco, M, Peschanski, M, Nissan, X

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Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 von Pitrez, Patricia R, Estronca, Luís, Monteiro, Luís Miguel, Colell, Guillem, Vazão, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire, Egesipe, Anne-Laure, Carvalho, Tânia, Dos Santos, Rodrigo L, Lévy, Nicolas, Smith, James C, de Magalhaes, Joao Pedro, Ori, Alessandro, Bernardo, Andreia, De Sandre-Giovannoli, Annachiara, Nissan, Xavier, Rosell Novel, Anna, Ferreira, Lino, Universitat Autònoma de Barcelona

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Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework von Ollier, Romain, Fuchs, Aline, Gauye, Florence, Piorkowska, Katarzyna, Menant, Sébastien, Ratnam, Monisha, Montanari, Paolo, Guilhot, Florence, Phillipe, Didier, Audrain, Mickael, Egesipe, Anne-Laure, Névoltris, Damien, Seredenina, Tamara, Pfeifer, Andrea, Kosco-Vilbois, Marie, Afroz, Tariq

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Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13 von Pitrez, Patricia R, Estronca, Luís, Monteiro, Luís Miguel, Colell, Guillem, Vazão, Helena, Santinha, Deolinda, Harhouri, Karim, Thornton, Daniel, Navarro, Claire, Egesipe, Anne-Laure, Carvalho, Tânia, Dos Santos, Rodrigo L, Lévy, Nicolas, Smith, James C, de Magalhaes, Joao Pedro, Ori, Alessandro, Bernardo, Andreia, De Sandre-Giovannoli, Annachiara, Nissan, Xavier, Rosell Novel, Anna, Ferreira, Lino, Universitat Autònoma de Barcelona

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Transcriptome analysis of HAoSMCs [Contrasts between groups] von Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter, Ivanov, Nikolai, Peitsch, Manuel, Hoeng, Julia

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Transcriptome analysis of HAoSMCs [Group level statistics] von Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter, Ivanov, Nikolai, Peitsch, Manuel, Hoeng, Julia

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Transcriptome analysis of HAoSMCs [Individual measurements] von Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter, Ivanov, Nikolai, Peitsch, Manuel, Hoeng, Julia

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High-content screening assays [Individual measurements] von Poussin, Carine, van der Toorn, Marco, Scheuner, Sophie, Piault, Romain, Kondylis, Athanasios, Savioz, Rebecca, Dulize, Rémi, Peric, Dariusz, Guedj, Emmanuel, Maranzano, Fabio, Merg, Celine, Morelli, Moran, Egesipe, Anne-Laure, Johne, Stéphanie, Majeed, Shoaib, Pak, Claudius, Schneider, Thomas, Schlage, Walter, Ivanov, Nikolai, Peitsch, Manuel, Hoeng, Julia

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