Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation von Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Vassallo, Laura M

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Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes von Grobler, Jay A., Stillmock, Kara, Hu, Binghua, Witmer, Marc, Felock, Peter, Espeseth, Amy S., Wolfe, Abigail, Egbertson, Melissa, Bourgeois, Michele, Melamed, Jeffrey, Wai, John S., Young, Steve, Vacca, Joseph, Hazuda, Daria J.

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HIV-1 Integrase Inhibitors That Compete with the Target DNA Substrate Define a Unique Strand Transfer Conformation for Integrase von Espeseth, Amy S., Felock, Peter, Wolfe, Abigail, Witmer, Marc, Grobler, Jay, Anthony, Neville, Egbertson, Melissa, Melamed, Jeffrey Y., Young, Steve, Hamill, Terence, Cole, James L., Hazuda, Daria J.

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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells von Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D

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Serendipitous discovery of a pH-dependant atropisomer bond rotation: Toward a write-protectable chiral molecular switch? von Welch, Christopher J., Biba, Mirlinda, Pye, Philip, Angelaud, Remy, Egbertson, Melissa

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Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells von Zhuang, Linghang, Wai, John S, Embrey, Mark W, Fisher, Thorsten E, Egbertson, Melissa S, Payne, Linda S, Guare, James P, Vacca, Joseph P, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Witmer, Marc V, Moyer, Gregory, Schleif, William A, Gabryelski, Lori J, Leonard, Yvonne M, Lynch, Joseph J, Michelson, Stuart R, Young, Steven D

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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or rest... von Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D

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Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation von Egbertson, M.S., Hartman, G.D., Gould, R.J., Bednar, B., Bednar, R.A., Cook, J.J., Gaul, S.L., Holahan, M.A., Libby, L.A., Lynch, J.J., Lynch, R.J., Sitko, G.R., Stranieri, M.T., Vassallo, L.M.

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Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp von Egbertson, Melissa S, Chang, Charles T.-C, Duggan, Mark E, Gould, Robert J, Halczenko, Wasyl, Hartman, George D, Laswell, William L, Lynch, Joseph J, Lynch, Robert J

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Non-peptide glycoprotein IIb/IIIa inhibitors. 9. Centrally constrained alpha-sulfonamides are useful tools for exploring platelet receptor function von Egbertson, M.S., Bednar, B., Bednar, R.A., Hartman, G.D., Gould, R.J., Lynch, R.J., Vassallo, L.M., Young, S.D.

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DNA cross-linking by intermediates in the mitomycin activation cascade von Cera, Cinzia, Egbertson, Melissa, Teng, Sally P, Crothers, Donald M, Danishefsky, Samuel J

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A Selective Protection of 2,3-Diaminopropionic Acid von Egbertson, M. S., Homnick, C. F., Hartman, G. D.

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NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS .1. DISCOVERY AND DESIGN OF EXOSITE INHIBITORS von HARTMAN, GD, EGBERTSON, MS, HALCZENKO, W, LASWELL, WL, DUGGAN, ME, SMITH, RL, NAYLOR, AM, MANNO, PD, LYNCH, RJ, ZHANG, GX, CHANG, CTC, GOULD, RJ

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Non-peptide fibrinogen receptor antagonists. 3. design and discovery of a centrally constrained inhibitor von Egbertson, M.S., Naylor, A.M., Hartman, G.D., Cook, J.J., Gould, R.J., Holahan, M.A., Lynch, J.J., Lynch, R.J., Stranieri, M.T., Vassallo, L.M.

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The characterization of intermediates in the mitomycin activation cascade: a practical synthesis of an aziridinomitosene von Danishefsky, Samuel J, Egbertson, Melissa

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Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semiquinone as the active electrophile von Egbertson, Melissa, Danishefsky, Samuel J

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Tirofiban (Aggrastat®) von Cook, Jacquelynn J., Bednar, Bohumil, Lynch, Joseph J., Gould, Robert J., Egbertson, Melissa S., Halczenko, Wasyl, Duggan, Mark E., Hartman, George D., Lo, Man‐Wai, Murphy, Gail M., Deckelbaum, Lawrence I., Sax, Frederick L., Barr, Eliav

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A synthetic route to the tricarbonyl region of FK-506 von Egbertson, Melissa, Danishefsky, Samuel J

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Non-peptide fibrinogen receptor antagonists. 4. Proposed three-dimensional requirements in centrally constrained inhibitors von Naylor, A.M., Egbertson, M.S., Vassallo, L.M., Birchenough, L.A., Zhang, G.X., Gould, R.J., Hartman, G.D.

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Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine‐glycine‐aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets von Bednar, Bohumil, Cunningham, Michael E., McQueney, Patricia A., Egbertson, Melissa S., Askew, Benny C., Bednar, Rodney A., Hartman, George D., Gould, Robert J.

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