Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening von Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, Gerwen, Bastiaan van, van der Ven, Marieke, Wetering, Marc van de, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J

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Signal Inhibitory Receptor on Leukocytes-1 Limits the Formation of Neutrophil Extracellular Traps, but Preserves Intracellular Bacterial Killing von Van Avondt, Kristof, van der Linden, Maarten, Naccache, Paul H, Egan, David A, Meyaard, Linde

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TMEM59 potentiates Wnt signaling by promoting signalosome formation von Gerlach, Jan P., Jordens, Ingrid, Tauriello, Daniele V. F., van ’t Land-Kuper, Ineke, Bugter, Jeroen M., Noordstra, Ivar, van der Kooij, Johanneke, Low, Teck Y., Pimentel-Muiños, Felipe X., Xanthakis, Despina, Fenderico, Nicola, Rabouille, Catherine, Heck, Albert J. R., Egan, David A., Maurice, Madelon M.

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Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation von Albers, Harald M.H.G, Dong, Anping, van Meeteren, Laurens A, Egan, David A, Sunkara, Manjula, van Tilburg, Erica W, Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J, Smyth, Susan S, Moolenaar, Wouter H, Ovaa, Huib

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In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells von Prins, Henk-Jan, Braat, A. Koen, Gawlitta, D., Dhert, Wouter J.A., Egan, David A., Tijssen-Slump, Estel, Yuan, Huipin, Coffer, Paul J., Rozemuller, Henk, Martens, Anton C.

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Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells von Karantzelis, Nikolaos, Petropoulos, Michalis, De Marco, Valeria, Egan, David A, Fish, Alexander, Christodoulou, Evangelos, Will, David W, Lewis, Joe D, Perrakis, Anastassis, Lygerou, Zoi, Taraviras, Stavros

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Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78 von DAVIDSON, Don J, HASKELL, Catherine, LESNIEWSKI, Rick, HENKIN, Jack, MAJEST, Sandy, KHERZAI, Abdullah, EGAN, David A, WALTER, Karl A, SCHNEIDER, Andrew, GUBBINS, Earl F, SOLOMON, Larry, ZHEBO CHEN

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Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation von van Heesbeen, Roy G. H. P., Raaijmakers, Jonne A., Tanenbaum, Marvin E., Halim, Vincentius A., Lelieveld, Daphne, Lieftink, Cor, Heck, Albert J. R., Egan, David A., Medema, René H.

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Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis von van der Velden, Lieke M., Maas, Peter, van Amersfoort, Miranda, Timmermans-Sprang, Elpetra P M., Mensinga, Anneloes, van der Vaart, Elisabeth, Malergue, Fabrice, Viëtor, Henk, Derksen, Patrick W B., Klumperman, Judith, van Agthoven, Andreas, Egan, David A., Mol, Jan A., Strous, Ger J.

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Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin von Albers, Harald M. H. G, van Meeteren, Laurens A, Egan, David A, van Tilburg, Erica W, Moolenaar, Wouter H, Ovaa, Huib

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A High-Throughput Pharmaceutical Screen Identifies Compounds with Specific Toxicity against BRCA2-Deficient Tumors von EVERS, Bastiaan, SCHUT, Eva, JONKERS, Jos, VAN DER BURG, Eline, BRAUMULLER, Tanya M, EGAN, David A, HOLSTEGE, Henne, EDSER, Pauline, ADAMS, David J, WADE-MARTINS, Richard, BOUWMAN, Peter

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Intra-tumour diversification in colorectal cancer at the single-cell level von Roerink, Sophie F., Sasaki, Nobuo, Lee-Six, Henry, Young, Matthew D., Alexandrov, Ludmil B., Behjati, Sam, Mitchell, Thomas J., Grossmann, Sebastian, Lightfoot, Howard, Egan, David A., Pronk, Apollo, Smakman, Niels, van Gorp, Joost, Anderson, Elizabeth, Gamble, Stephen J., Alder, Chris, van de Wetering, Marc, Campbell, Peter J., Stratton, Michael R., Clevers, Hans

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A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation von Paul, Petra, van den Hoorn, Tineke, Jongsma, Marlieke L.M., Bakker, Mark J., Hengeveld, Rutger, Janssen, Lennert, Cresswell, Peter, Egan, David A., van Ham, Marieke, ten Brinke, Anja, Ovaa, Huib, Beijersbergen, Roderick L., Kuijl, Coenraad, Neefjes, Jacques

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CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches von Argiriadi, Maria A, Benatuil, Lorenzo, Dubrovska, Ievgeniia, Egan, David A, Gao, Lei, Greischar, Amy, Hardman, Jennifer, Harlan, John, Iyer, Ramesh B, Judge, Russell A, Lake, Marc, Perron, Denise C, Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Wang, Rui, McRae, Bradford L

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Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation von le Sage, Carlos, Nagel, Remco, Egan, David A, Schrier, Mariette, Mesman, Elly, Mangiola, Annunziato, Anile, Corrado, Maira, Giulio, Mercatelli, Neri, Ciafrè, Silvia Anna, Farace, Maria Giulia, Agami, Reuven

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Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core von van Welsem, Tibor, Frederiks, Floor, Verzijlbergen, Kitty F., Faber, Alex W., Nelson, Zara W., Egan, David A., Gottschling, Daniel E., van Leeuwen, Fred

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The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis von Huang, Qihong, Gumireddy, Kiranmai, Schrier, Mariette, le Sage, Carlos, Nagel, Remco, Nair, Suresh, Egan, David A., Li, Anping, Huang, Guanghua, Klein-Szanto, Andres J., Gimotty, Phyllis A., Katsaros, Dionyssios, Coukos, George, Zhang, Lin, Puré, Ellen, Agami, Reuven

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Physiologically Relevant Metal Cofactor for Methionine Aminopeptidase-2 Is Manganese von Wang, Jieyi, Sheppard, George S, Lou, Pingping, Kawai, Megumi, Park, Chang, Egan, David A, Schneider, Andrew, Bouska, Jennifer, Lesniewski, Rick, Henkin, Jack

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Modulation of CREB Binding Protein Function by the Promyelocytic (PML) Oncoprotein Suggests a Role for Nuclear Bodies in Hormone Signaling von Doucas, Vassilis, Tini, Marc, Egan, David A., Evans, Ronald M.

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Paired image- and FACS-based toxicity assays for high content screening of spheroid-type tumor cell cultures von Trumpi, Kari, Egan, David A., Vellinga, Thomas T., Borel Rinkes, Inne H.M., Kranenburg, Onno

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