Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome von Mira, Juan C., Gentile, Lori F., Mathias, Brittany J., Efron, Philip A., Brakenridge, Scott C., Mohr, Alicia M., Moore, Frederick A., Moldawer, Lyle L.

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Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome von Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Horiguchi, Hiroyuki, Brakenridge, Scott C, Gardner, Anna, Efron, Philip A, Bihorac, Azra, Segal, Mark, Moore, Frederick A, Moldawer, Lyle L

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Successful aging: Advancing the science of physical independence in older adults von Anton, Stephen D, Woods, Adam J, Ashizawa, Tetso, Barb, Diana, Buford, Thomas W, Carter, Christy S, Clark, David J, Cohen, Ronald A, Corbett, Duane B, Cruz-Almeida, Yenisel, Dotson, Vonetta, Ebner, Natalie, Efron, Philip A, Fillingim, Roger B, Foster, Thomas C, Gundermann, David M, Joseph, Anna-Maria, Karabetian, Christy, Leeuwenburgh, Christiaan, Manini, Todd M, Marsiske, Michael, Mankowski, Robert T, Mutchie, Heather L, Perri, Michael G, Ranka, Sanjay, Rashidi, Parisa, Sandesara, Bhanuprasad, Scarpace, Philip J, Sibille, Kimberly T, Solberg, Laurence M, Someya, Shinichi, Uphold, Connie, Wohlgemuth, Stephanie, Wu, Samuel Shangwu, Pahor, Marco

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Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis von Hollen, McKenzie K, Stortz, Julie A, Darden, Dijoia, Dirain, Marvin L, Nacionales, Dina C, Hawkins, Russell B, Cox, Michael C, Lopez, Maria-Cecilia, Rincon, Jaimar C, Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L, Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A, Baker, Henry V, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

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Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients von Stortz, Julie A, Mira, Juan C, Raymond, Steven L, Loftus, Tyler J, Ozrazgat-Baslanti, Tezcan, Wang, Zhongkai, Ghita, Gabriela L, Leeuwenburgh, Christiaan, Segal, Mark S, Bihorac, Azra, Brumback, Babette A, Mohr, Alicia M, Efron, Philip A, Moldawer, Lyle L, Moore, Frederick A, Brakenridge, Scott C

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The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients von Brakenridge, Scott C, Efron, Philip A, Stortz, Julie A, Ozrazgat-Baslanti, Teczan, Ghita, Gabriela, Wang, Zhongkai, Bihorac, Azra, Mohr, Alicia M, Brumback, Babette A, Moldawer, Lyle L, Moore, Frederick A

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Improved emergency myelopoiesis and survival in neonatal sepsis by caspase‐1/11 ablation von Gentile, Lori F., Cuenca, Angela L., Cuenca, Alex G., Nacionales, Dina C., Ungaro, Ricardo, Efron, Philip A., Moldawer, Lyle L., Larson, Shawn D.

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Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study von Balch, Jeremy A, Chen, Uan-I, Liesenfeld, Oliver, Starostik, Petr, Loftus, Tyler J, Efron, Philip A, Brakenridge, Scott C, Sweeney, Timothy E, Moldawer, Lyle L

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Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy von Horiguchi, Hiroyuki, Loftus, Tyler J, Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Hollen, McKenzie K, Weiss, Brett P, Miller, Elizabeth S, Bihorac, Azra, Larson, Shawn D, Mohr, Alicia M, Brakenridge, Scott C, Tsujimoto, Hironori, Ueno, Hideki, Moore, Frederick A, Moldawer, Lyle L, Efron, Philip A

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Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study von Stortz, Julie A., Cox, Michael C., Hawkins, Russell B., Ghita, Gabriela L., Brumback, Babette A., Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A., Brakenridge, Scott C., Moore, Frederick A.

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Unique transcriptomic response to sepsis is observed among patients of different age groups von Raymond, Steven L, López, María Cecilia, Baker, Henry V, Larson, Shawn D, Efron, Philip A, Sweeney, Timothy E, Khatri, Purvesh, Moldawer, Lyle L, Wynn, James L

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Role of Toll-like receptors in the development of sepsis von Tsujimoto, Hironori, Ono, Satoshi, Efron, Philip A, Scumpia, Philip O, Moldawer, Lyle L, Mochizuki, Hidetaka

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B cells enhance early innate immune responses during bacterial sepsis von Kelly-Scumpia, Kindra M, Scumpia, Philip O, Weinstein, Jason S, Delano, Matthew J, Cuenca, Alex G, Nacionales, Dina C, Wynn, James L, Lee, Pui Y, Kumagai, Yutaro, Efron, Philip A, Akira, Shizuo, Wasserfall, Clive, Atkinson, Mark A, Moldawer, Lyle L

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The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis von Cox, Michael C., Booth, Matthew, Ghita, Gabriela, Wang, Zhongkai, Gardner, Anna, Hawkins, Russell B., Darden, Dijoia B., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Moore, Frederick A., Efron, Philip A., Anton, Steven, Brakenridge, Scott C.

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Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis von Loftus, Tyler J., Ungaro, Ricardo, Dirain, Marvin, Efron, Philip A., Mazer, Monty B., Remy, Kenneth E., Hotchkiss, Richard S., Zhong, Luer, Bacher, Rhonda, Starostik, Petr, Moldawer, Lyle L., Brakenridge, Scott C.

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Dysregulated Immunity and Immunotherapy after Sepsis von Darden, Dijoia B., Kelly, Lauren S., Fenner, Brittany P., Moldawer, Lyle L., Mohr, Alicia M., Efron, Philip A.

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Machine Learning Applications in Solid Organ Transplantation and Related Complications von Balch, Jeremy A. A., Delitto, Daniel, Tighe, Patrick J. J., Zarrinpar, Ali, Efron, Philip A. A., Rashidi, Parisa, Upchurch Jr, Gilbert R. R., Bihorac, Azra, Loftus, Tyler J. J.

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Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates von Young, Whitney A., MD, Fallon, Eleanor A., MD, Heffernan, Daithi S., MD, Efron, Philip A., MD, Cioffi, William G., MD, Ayala, Alfred, PhD

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Protective immunity and defects in the neonatal and elderly immune response to sepsis von Gentile, Lori F, Nacionales, Dina C, Lopez, M Cecilia, Vanzant, Erin, Cuenca, Angela, Cuenca, Alex G, Ungaro, Ricardo, Szpila, Ben E, Larson, Shawn, Joseph, Anna, Moore, Frederick A, Leeuwenburgh, Christiaan, Baker, Henry V, Moldawer, Lyle L, Efron, Philip A

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Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors von Custodero, Carlo, Wu, Quran, Ghita, Gabriela L, Anton, Stephen D, Brakenridge, Scott C, Brumback, Babette A, Efron, Philip A, Gardner, Anna K, Leeuwenburgh, Christiaan, Moldawer, Lyle L, Petersen, John W, Moore, Frederick A, Mankowski, Robert T

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