Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome von Mira, Juan C., Gentile, Lori F., Mathias, Brittany J., Efron, Philip A., Brakenridge, Scott C., Mohr, Alicia M., Moore, Frederick A., Moldawer, Lyle L.

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Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome von Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Horiguchi, Hiroyuki, Brakenridge, Scott C, Gardner, Anna, Efron, Philip A, Bihorac, Azra, Segal, Mark, Moore, Frederick A, Moldawer, Lyle L

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Successful aging: Advancing the science of physical independence in older adults von Anton, Stephen D, Woods, Adam J, Ashizawa, Tetso, Barb, Diana, Buford, Thomas W, Carter, Christy S, Clark, David J, Cohen, Ronald A, Corbett, Duane B, Cruz-Almeida, Yenisel, Dotson, Vonetta, Ebner, Natalie, Efron, Philip A, Fillingim, Roger B, Foster, Thomas C, Gundermann, David M, Joseph, Anna-Maria, Karabetian, Christy, Leeuwenburgh, Christiaan, Manini, Todd M, Marsiske, Michael, Mankowski, Robert T, Mutchie, Heather L, Perri, Michael G, Ranka, Sanjay, Rashidi, Parisa, Sandesara, Bhanuprasad, Scarpace, Philip J, Sibille, Kimberly T, Solberg, Laurence M, Someya, Shinichi, Uphold, Connie, Wohlgemuth, Stephanie, Wu, Samuel Shangwu, Pahor, Marco

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Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis von Hollen, McKenzie K, Stortz, Julie A, Darden, Dijoia, Dirain, Marvin L, Nacionales, Dina C, Hawkins, Russell B, Cox, Michael C, Lopez, Maria-Cecilia, Rincon, Jaimar C, Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L, Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A, Baker, Henry V, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

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Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients von Stortz, Julie A, Mira, Juan C, Raymond, Steven L, Loftus, Tyler J, Ozrazgat-Baslanti, Tezcan, Wang, Zhongkai, Ghita, Gabriela L, Leeuwenburgh, Christiaan, Segal, Mark S, Bihorac, Azra, Brumback, Babette A, Mohr, Alicia M, Efron, Philip A, Moldawer, Lyle L, Moore, Frederick A, Brakenridge, Scott C

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Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner von Vo, Quan, Simon, Zachary D., Park, Gwoncheol, Nacionales, Dina C, Gorski, Carmelina, Barrios, Evan L, Casadesus, Gemma, Efron, Philip A, Moldawer, Lyle L, Nagpal, Ravinder, Chakrabarty, Paramita, Febo, Marcelo

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The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients von Brakenridge, Scott C, Efron, Philip A, Stortz, Julie A, Ozrazgat-Baslanti, Teczan, Ghita, Gabriela, Wang, Zhongkai, Bihorac, Azra, Mohr, Alicia M, Brumback, Babette A, Moldawer, Lyle L, Moore, Frederick A

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Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study von Balch, Jeremy A, Chen, Uan-I, Liesenfeld, Oliver, Starostik, Petr, Loftus, Tyler J, Efron, Philip A, Brakenridge, Scott C, Sweeney, Timothy E, Moldawer, Lyle L

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Improved emergency myelopoiesis and survival in neonatal sepsis by caspase‐1/11 ablation von Gentile, Lori F., Cuenca, Angela L., Cuenca, Alex G., Nacionales, Dina C., Ungaro, Ricardo, Efron, Philip A., Moldawer, Lyle L., Larson, Shawn D.

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Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy von Horiguchi, Hiroyuki, Loftus, Tyler J, Hawkins, Russell B, Raymond, Steven L, Stortz, Julie A, Hollen, McKenzie K, Weiss, Brett P, Miller, Elizabeth S, Bihorac, Azra, Larson, Shawn D, Mohr, Alicia M, Brakenridge, Scott C, Tsujimoto, Hironori, Ueno, Hideki, Moore, Frederick A, Moldawer, Lyle L, Efron, Philip A

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Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study von Stortz, Julie A, Cox, Michael C, Hawkins, Russell B, Ghita, Gabriela L, Brumback, Babette A, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A, Brakenridge, Scott C, Moore, Frederick A

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The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis von Cox, Michael C., Booth, Matthew, Ghita, Gabriela, Wang, Zhongkai, Gardner, Anna, Hawkins, Russell B., Darden, Dijoia B., Leeuwenburgh, Christiaan, Moldawer, Lyle L., Moore, Frederick A., Efron, Philip A., Anton, Steven, Brakenridge, Scott C.

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Unique transcriptomic response to sepsis is observed among patients of different age groups von Raymond, Steven L, López, María Cecilia, Baker, Henry V, Larson, Shawn D, Efron, Philip A, Sweeney, Timothy E, Khatri, Purvesh, Moldawer, Lyle L, Wynn, James L

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Dysregulated Immunity and Immunotherapy after Sepsis von Darden, Dijoia B, Kelly, Lauren S, Fenner, Brittany P, Moldawer, Lyle L, Mohr, Alicia M, Efron, Philip A

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Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis von Loftus, Tyler J, Ungaro, Ricardo, Dirain, Marvin, Efron, Philip A, Mazer, Monty B, Remy, Kenneth E, Hotchkiss, Richard S, Zhong, Luer, Bacher, Rhonda, Starostik, Petr, Moldawer, Lyle L, Brakenridge, Scott C

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Machine Learning Applications in Solid Organ Transplantation and Related Complications von Balch, Jeremy A, Delitto, Daniel, Tighe, Patrick J, Zarrinpar, Ali, Efron, Philip A, Rashidi, Parisa, Upchurch, Jr, Gilbert R, Bihorac, Azra, Loftus, Tyler J

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Role of Toll-like receptors in the development of sepsis von Tsujimoto, Hironori, Ono, Satoshi, Efron, Philip A, Scumpia, Philip O, Moldawer, Lyle L, Mochizuki, Hidetaka

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B cells enhance early innate immune responses during bacterial sepsis von Kelly-Scumpia, Kindra M, Scumpia, Philip O, Weinstein, Jason S, Delano, Matthew J, Cuenca, Alex G, Nacionales, Dina C, Wynn, James L, Lee, Pui Y, Kumagai, Yutaro, Efron, Philip A, Akira, Shizuo, Wasserfall, Clive, Atkinson, Mark A, Moldawer, Lyle L

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Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates von Young, Whitney A., MD, Fallon, Eleanor A., MD, Heffernan, Daithi S., MD, Efron, Philip A., MD, Cioffi, William G., MD, Ayala, Alfred, PhD

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A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis von Darden, Dijoia B, Dong, Xiaoru, Brusko, Maigan A, Kelly, Lauren, Fenner, Brittany, Rincon, Jaimar C, Dirain, Marvin L, Ungaro, Ricardo, Nacionales, Dina C, Gauthier, Marie, Kladde, Michael, Brusko, Todd M, Bihorac, Azra, Moore, Frederick A, Loftus, Tyler, Bacher, Rhonda, Moldawer, Lyle L, Mohr, Alicia M, Efron, Philip A

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