PWE-171 Mobile element insertions are frequent and potentially mutagenic events in oesophageal carcinogenesis von Paterson, AL, Weaver, JMJ, Eldridge, M, Tavare, S, Fitzgerald, RC, Edwards, PAW

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The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene von Chua, Y L, Ito, Y, Pole, J C M, Newman, S, Chin, S -F, Stein, R C, Ellis, I O, Caldas, C, O'Hare, M J, Murrell, A, Edwards, P A W

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A 1 Mb minimal amplicon at 8p11–12 in breast cancer identifies new candidate oncogenes von Garcia, Maria J, Pole, Jessica C M, Chin, Suet-Feung, Teschendorff, Andrew, Naderi, Ali, Ozdag, Hilal, Vias, Maria, Kranjac, Tanja, Subkhankulova, Tatiana, Paish, Claire, Ellis, Ian, Brenton, James D, Edwards, Paul A W, Caldas, Carlos

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Value networks identify innovation in 21st century pharmaceutical research von Edwards, Paul J.

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Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas von Ng, AWT, Contino, G, Killcoyne, S, Devonshire, G, Hsu, R, Abbas, S, Su, J, Redmond, AM, Weaver, JMJ, Eldridge, MD, Tavaré, S, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Edwards, PAW, Fitzgerald, RC

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A 1Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes von GARCIA, Maria J, POLE, Jessica C. M, ELLIS, Ian, BRENTON, James D, EDWARDS, Paul A. W, CALDAS, Carlos, CHIN, Suet-Feung, TESCHENDORFF, Andrew, NADERI, Ali, OZDAG, Hilal, VIAS, Maria, KRANJAC, Tanja, SUBKHANKULOVA, Tatiana, PAISH, Claire

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Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma von Mourikis, TP, Benedetti, L, Foxall, E, Temelkovski, D, Nulsen, J, Perner, J, Cereda, M, Lagergren, J, Howell, M, Yau, C, Fitzgerald, RC, Scaffidi, P, Noorani, A, Edwards, PAW, Elliott, RF, Grehan, N, Nutzinger, B, Hughes, C, Fidziukiewicz, E, Bornschein, J, MacRae, S, Crawte, J, Northrop, A, Contino, G, Li, X, De la Rue, R, Katz-Summercorn, A, Abbas, S, Loureda, D, O'Donovan, M, Miremadi, A, Malhotra, S, Tripathi, M, Tavare, S, Lynch, AG, Eldridge, M, Secrier, M, Bower, L, Devonshire, G, Jammula, S, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Moorthy, K, Grabowska, A, Turkington, R, McManus, D, Khoo, D, Fickling, W, Ciccarelli, FD

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Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction von Bornschein, J, Wernisch, L, Secrier, M, Miremadi, A, Perner, J, MacRae, S, O'Donovan, M, Newton, R, Menon, S, Bower, L, Eldridge, MD, Devonshire, G, Cheah, C, Turkington, R, Hardwick, RH, Selgrad, M, Venerito, M, Malfertheiner, P, Fitzgerald, RC, Noorani, A, Elliott, RF, Edwards, PAW, Grehan, N, Nutzinger, B, Crawte, J, Chettouh, H, Contino, G, Li, X, Gregson, E, Zeki, S, De la Rue, R, Malhotra, S, Tavare, S, Lynch, AG, Smith, ML, Davies, J, Crichton, C, Carroll, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, TJ, Noble, F, Owsley, J, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Peters, CJ, Grabowska, A

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The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic von Frankell, AM, Jammula, S, Li, X, Contino, G, Killcoyne, S, Abbas, S, Perner, J, Bower, L, Devonshire, G, Cocks, E, Grehan, N, Mok, J, O'Donovan, M, MacRae, S, Eldridge, MD, Tavare, S, Fitzgerald, RC, Noorani, A, Edwards, PAW, Grehanl, N, Nutzinger, B, Hughes, CI, Fidziukiewicz, E, Northrop, A, De la Rue, R, Katz-Summercorn, A, Loureda, D, Miremadi, A, Malhotra, S, Tripathi, M, Lynch, AG, Eldridge, M, Secrier, M, Davies, J, Crichton, C, Carro, N, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, ONeill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Underwood, T, Walker, RC, Grace, BL, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Mahadeva, U, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Harden, C, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Igali, L, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Hanna, GB, Moorthy, K, Peters, CJ, Grabowska, A, Turkington, R, McManus, D, Coleman, H, Khoo, D, Fickling, W

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Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes von Howarth, K D, Blood, K A, Ng, B L, Beavis, J C, Chua, Y, Cooke, S L, Raby, S, Ichimura, K, Collins, V P, Carter, N P, Edwards, P A W

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Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism von Lynch, D K, Ellis, C A, Edwards, P A, Hiles, I D

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Spectral Karyotyping Suggests Additional Subsets of Colorectal Cancers Characterized by Pattern of Chromosome Rearrangement von Abdel-Rahman, Wael M., Katsura, Kanade, Rens, Willem, Gorman, Patricia A., Sheer, Denise, Bicknell, David, Bodmer, Walter F., Arends, Mark J., Wyllie, Andrew H., Paul A. W. Edwards

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A recurrent chromosome breakpoint in breast cancer at the NRG1/Neuregulin 1/Heregulin gene von HUANG, Huai-En, CHIN, Suet-Feung, GULLICK, William J, JACQUEMIER, Jocelyne, CALDAS, Carlos, CHAFFANET, Max, BIRNBAUM, Daniel, EDWARDS, Paul A. W, GINESTIER, Christophe, BARDOU, Valérie-Jeanne, ADELAÏDE, José, GOPALAKRISHNA IYER, N, GARCIA, Maria J, POLE, Jessica C, CALLAGY, Grace M, HEWITT, Stephen M

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The NEUREGULIN1gene and breast cancer von Chua, YL, Edwards, PAW

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Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1 von Garcia, E, Hayden, A, Birts, C, Britton, E, Cowie, A, Pickard, K, Mellone, M, Choh, C, Derouet, M, Duriez, P, Noble, F, White, MJ, Primrose, JN, Strefford, JC, Rose-Zerilli, M, Thomas, GJ, Ang, Y, Sharrocks, AD, Fitzgerald, RC, Underwood, TJ, MacRae, S, Grehan, N, Abdullahi, Z, De la Rue, R, Noorani, A, Elliott, RF, De Silva, N, Bornschein, J, O’Donovan, M, Contino, G, Yang, T-P, Chettouh, H, Crawte, J, Nutzinger, B, Edwards, PAW, Smith, L, Miremadi, A, Malhotra, S, Cluroe, A, Hardwick, R, Davies, J, Ford, H, Gilligan, D, Safranek, P, Hindmarsh, A, Sujendran, V, Carroll, N, Turkington, R, Hayes, SJ, Preston, SR, Oakes, S, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O’Neill, JR, Tucker, O, Taniere, P, Owsley, J, Crichton, C, Schusterreiter, C, Barr, H, Shepherd, N, Old, O, Lagergren, J, Gossage, J, Davies, A, Chang, F, Zylstra, J, Sanders, G, Berrisford, R, Harden, C, Bunting, D, Lewis, M, Cheong, E, Kumar, B, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Eneh, V, Igali, L, Welch, I, Scott, M, Sothi, S, Suortamo, S, Lishman, S, Beardsmore, D, Anderson, C, Smith, ML, Secrier, M, Eldridge, MD, Bower, L, Achilleos, A, Lynch, AG, Tavare, S

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Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer von Gorringe, Kylie L., Chin, Suet-Feung, Pharoah, Paul, Staines, Joanne M., Oliveira, Carla, Edwards, Paul A.W., Caldas, Carlos

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The NEUREGULIN1 gene and breast cancer von Chua, YL, Edwards, PAW

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Molecular cytogenetic analysis of breast cancer cell lines von Davidson, J M, Gorringe, K L, Chin, S-F, Orsetti, B, Besret, C, Courtay-Cahen, C, Roberts, I, Theillet, C, Caldas, C, Edwards, P A W

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Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous von Fantl, Vera, Edwards, Paul A.W., Steel, Jennifer H., Vonderhaar, Barbara K., Dickson, Clive

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Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1 von Grigorova, M., Staines, J.M., Ozdag, H., Caldas, C., Edwards, P.A.W.

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