Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice von Kadiyala, Padma, Carney, Stephen V, Gauss, Jessica C, Garcia-Fabiani, Maria B, Haase, Santiago, Alghamri, Mahmoud S, Núñez, Felipe J, Liu, Yayuan, Yu, Minzhi, Taher, Ayman, Nunez, Fernando M, Li, Dan, Edwards, Marta B, Kleer, Celina G, Appelman, Henry, Sun, Yilun, Zhao, Lili, Moon, James J, Schwendeman, Anna, Lowenstein, Pedro R, Castro, Maria G

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Systemic Delivery of an Adjuvant CXCR4–CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy von Alghamri, Mahmoud S., Banerjee, Kaushik, Mujeeb, Anzar A., Mauser, Ava, Taher, Ayman, Thalla, Rohit, McClellan, Brandon L., Varela, Maria L., Stamatovic, Svetlana M., Martinez-Revollar, Gabriela, Andjelkovic, Anuska V., Gregory, Jason V., Kadiyala, Padma, Calinescu, Alexandra, Jiménez, Jennifer A., Apfelbaum, April A., Lawlor, Elizabeth R., Carney, Stephen, Comba, Andrea, Faisal, Syed Mohd, Barissi, Marcus, Edwards, Marta B., Appelman, Henry, Sun, Yilun, Gan, Jingyao, Ackermann, Rose, Schwendeman, Anna, Candolfi, Marianela, Olin, Michael R., Lahann, Joerg, Lowenstein, Pedro R., Castro, Maria G.

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Incidence and Risk Factors for Anastomotic Failure in 1594 Patients Treated by Transanal Total Mesorectal Excision: Results From the International TaTME Registry von Penna, Marta, Hompes, Roel, Arnold, Steve, Wynn, Greg, Austin, Ralph, Warusavitarne, Janindra, Moran, Brendan, Hanna, George B., Mortensen, Neil J., Tekkis, Paris P.

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Current use of noninvasive prenatal testing in Europe, Australia and the USA: A graphical presentation von Gadsbøll, Kasper, Petersen, Olav B., Gatinois, Vincent, Strange, Heather, Jacobsson, Bo, Wapner, Ronald, Vermeesch, Joris R., Vogel, Ida

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The repertoire of mutational signatures in human cancer von Alexandrov, Ludmil B., Kim, Jaegil, Haradhvala, Nicholas J., Huang, Mi Ni, Tian Ng, Alvin Wei, Wu, Yang, Boot, Arnoud, Covington, Kyle R., Gordenin, Dmitry A., Bergstrom, Erik N., Islam, S. M. Ashiqul, Lopez-Bigas, Nuria, Klimczak, Leszek J., McPherson, John R., Morganella, Sandro, Sabarinathan, Radhakrishnan, Wheeler, David A., Mustonen, Ville, Getz, Gad, Rozen, Steven G., Stratton, Michael R.

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MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis von Kasivisvanathan, Veeru, Rannikko, Antti S, Borghi, Marcelo, Panebianco, Valeria, Mynderse, Lance A, Vaarala, Markku H, Briganti, Alberto, Budäus, Lars, Hellawell, Giles, Hindley, Richard G, Roobol, Monique J, Eggener, Scott, Ghei, Maneesh, Villers, Arnauld, Bladou, Franck, Villeirs, Geert M, Virdi, Jaspal, Boxler, Silvan, Robert, Grégoire, Singh, Paras B, Venderink, Wulphert, Hadaschik, Boris A, Ruffion, Alain, Hu, Jim C, Margolis, Daniel, Crouzet, Sébastien, Klotz, Laurence, Taneja, Samir S, Pinto, Peter, Gill, Inderbir, Allen, Clare, Giganti, Francesco, Freeman, Alex, Morris, Stephen, Punwani, Shonit, Williams, Norman R, Brew-Graves, Chris, Deeks, Jonathan, Takwoingi, Yemisi, Emberton, Mark, Moore, Caroline M

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Changes in Serum Metabolome Following Low-Energy Diet-Induced Weight Loss in Women with Overweight and Prediabetes: A PREVIEW-New Zealand Sub-Study von Relva, Bárbara, Samuelsson, Linda M, Duarte, Iola F, Fasol, Ulrike, Edwards, Patrick J B, Fogelholm, Mikael, Raben, Anne, Poppitt, Sally D, Silvestre, Marta P

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The evolutionary history of 2,658 cancers von Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Dentro, Stefan C., Gonzalez, Santiago, Rosebrock, Daniel, Mitchell, Thomas J., Rubanova, Yulia, Anur, Pavana, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vázquez-García, Ignacio, Haase, Kerstin, Jerman, Lara, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G., Cmero, Marek, Demeulemeester, Jonas, Schumacher, Steven, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C., Bowtell, David D., Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S. Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Van Loo, Peter

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Comprehensive molecular characterization of mitochondrial genomes in human cancers von Yuan, Yuan, Ju, Young Seok, Kim, Youngwook, Li, Jun, Wang, Yumeng, Yoon, Christopher J., Yang, Yang, Martincorena, Inigo, Creighton, Chad J., Weinstein, John N., Xu, Yanxun, Han, Leng, Kim, Hyung-Lae, Nakagawa, Hidewaki, Park, Keunchil, Campbell, Peter J., Liang, Han

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The landscape of viral associations in human cancers von Zapatka, Marc, Borozan, Ivan, Brewer, Daniel S., Iskar, Murat, Grundhoff, Adam, Alawi, Malik, Desai, Nikita, Sültmann, Holger, Moch, Holger, Cooper, Colin S., Eils, Roland, Ferretti, Vincent, Lichter, Peter

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T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial von Ewer, Katie J., Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Sharpe, Hannah, Makinson, Rebecca, Morter, Richard, Flaxman, Amy, Wright, Daniel, Bellamy, Duncan, Bittaye, Mustapha, Dold, Christina, Provine, Nicholas M., Aboagye, Jeremy, Fowler, Jamie, Silk, Sarah E., Alderson, Jennifer, Aley, Parvinder K., Angus, Brian, Berrie, Eleanor, Bibi, Sagida, Cicconi, Paola, Clutterbuck, Elizabeth A., Chelysheva, Irina, Folegatti, Pedro M., Fuskova, Michelle, Green, Catherine M., Jenkin, Daniel, Kerridge, Simon, Lawrie, Alison, Minassian, Angela M., Moore, Maria, Mujadidi, Yama, Plested, Emma, Poulton, Ian, Ramasamy, Maheshi N., Robinson, Hannah, Song, Rinn, Snape, Matthew D., Tarrant, Richard, Voysey, Merryn, Watson, Marion E. E., Douglas, Alexander D., Hill, Adrian V. S., Gilbert, Sarah C., Pollard, Andrew J., Lambe, Teresa

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Patterns of somatic structural variation in human cancer genomes von Li, Yilong, Roberts, Nicola D., Wala, Jeremiah A., Shapira, Ofer, Schumacher, Steven E., Kumar, Kiran, Khurana, Ekta, Waszak, Sebastian, Korbel, Jan O., Haber, James E., Imielinski, Marcin, Weischenfeldt, Joachim, Beroukhim, Rameen, Campbell, Peter J.

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Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study von Wagner, Sophia J., Reisenbüchler, Daniel, West, Nicholas P., Niehues, Jan Moritz, Zhu, Jiefu, Foersch, Sebastian, Veldhuizen, Gregory Patrick, Quirke, Philip, Grabsch, Heike I., van den Brandt, Piet A., Hutchins, Gordon G.A., Richman, Susan D., Yuan, Tanwei, Langer, Rupert, Jenniskens, Josien C.A., Offermans, Kelly, Mueller, Wolfram, Gray, Richard, Gruber, Stephen B., Greenson, Joel K., Rennert, Gad, Bonner, Joseph D., Schmolze, Daniel, Jonnagaddala, Jitendra, Hawkins, Nicholas J., Ward, Robyn L., Morton, Dion, Seymour, Matthew, Magill, Laura, Nowak, Marta, Hay, Jennifer, Koelzer, Viktor H., Church, David N., Church, David, Domingo, Enric, Edwards, Joanne, Glimelius, Bengt, Gogenur, Ismail, Harkin, Andrea, Hay, Jen, Iveson, Timothy, Jaeger, Emma, Kelly, Caroline, Kerr, Rachel, Maka, Noori, Morgan, Hannah, Oien, Karin, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Sansom, Owen, Saunders, Mark, Tomlinson, Ian, Matek, Christian, Geppert, Carol, Peng, Chaolong, Zhi, Cheng, Ouyang, Xiaoming, James, Jacqueline A., Loughrey, Maurice B., Salto-Tellez, Manuel, Brenner, Hermann, Hoffmeister, Michael, Truhn, Daniel, Schnabel, Julia A., Boxberg, Melanie, Peng, Tingying, Kather, Jakob Nikolas

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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing von Cortés-Ciriano, Isidro, Lee, Jake June-Koo, Xi, Ruibin, Jain, Dhawal, Jung, Youngsook L., Yang, Lixing, Gordenin, Dmitry, Klimczak, Leszek J., Zhang, Cheng-Zhong, Pellman, David S., Park, Peter J.

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Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution von Hiley, Crispin T., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Herrero, Javier, Swanton, Charles, Swanton, Charles, Czyzewska-Khan, Justyna, Gorman, Pat, Wilson, Gareth, Watkins, Thomas B.K., McGranahan, Nicholas, Mitter, Richard, Escudero, Mickael, Rowan, Andrew, Xu, Hang, Turajlic, Samra, Stone, Richard Kevin, Denner, Tamara, Costa, Marta, Phillimore, Ben, Joshi, Kroopa, Furness, Andrew, Ben Aissa, Assma, Wong, Yien Ning Sophia, Quezada, Sergio, Hartley, John A., Lowe, Helen L., Herrero, Javier, Lawrence, David, Falzon, Mary, Borg, Elaine, Marafioti, Teresa, Janes, Sam M., Thakrar, Ricky, Papadatos-Pastos, Dionysis, Choudhary, Junaid, Califano, Raffaele, Taylor, Paul, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Bishop, Paul, Chaturved, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Blackhall, Fiona, Chemi, Francesca, Gulati, Sakshi, Naidu, Babu, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Middleton, Gary, Shaw, Jacqui A., Le Quesne, John, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Riley, Joan, Primrose, Lindsay, Anand, Girija, Nicolson, Marianne, Palmer, Shirley, Buchan, Keith, Chetty, Mahendran, Edwards, Alison, Morgan, Fiona, Davies, Helen, Verjee, Azmina, MacKenzie, Mairead, Hackshaw, Allan, Smith, Sean, Alzetani, Aiman, Shaw, Emily, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Bhayani, Harshil, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-sellers, Melanie, Prakash, Vineet, Horey, Tracey, Hill, Jennifer, Suvarna, Kim, Keerio, Allah Dino, Feeney, Sarah, Asante-Siaw, Julius, Dessimoz, Christophe

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Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution von Abbosh, Christopher, Birkbak, Nicolai J., Wilson, Gareth A., Jamal-Hanjani, Mariam, Constantin, Tudor, Salari, Raheleh, Le Quesne, John, Moore, David A., Veeriah, Selvaraju, Rosenthal, Rachel, Marafioti, Teresa, Kirkizlar, Eser, McGranahan, Nicholas, Ward, Sophia, Martinson, Luke, Riley, Joan, Fraioli, Francesco, Al Bakir, Maise, Grönroos, Eva, Zambrana, Francisco, Endozo, Raymondo, Bi, Wenya Linda, Fennessy, Fiona M., Sponer, Nicole, Johnson, Diana, Laycock, Joanne, Shafi, Seema, Czyzewska-Khan, Justyna, Rowan, Andrew, Chambers, Tim, Matthews, Nik, Hiley, Crispin, Lee, Siow Ming, Forster, Martin D., Ahmad, Tanya, Falzon, Mary, Borg, Elaine, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M., Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Naik, Ashwini, Ganguly, Apratim, Kareht, Stephanie, Shah, Rajesh, Joseph, Leena, Marie Quinn, Anne, Crosbie, Phil A., Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A., Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F., Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Oukrif, Dahmane, Akarca, Ayse U., Hartley, John A., Lowe, Helen L., Lock, Sara, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Elgar, Greg, Szallasi, Zoltan, Schwarz, Roland F., Herrero, Javier, Stewart, Aengus, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Lin, C. Jimmy, Rabinowitz, Matthew, Aerts, Hugo J. W. L., Hackshaw, Allan, Shaw, Jacqui A., Zimmermann, Bernhard G., Swanton, Charles

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Assessment of NAAPS-RA performance in Maritime Southeast Asia during CAMP2Ex von Edwards, Eva-Lou, Reid, Jeffrey S, Peng Xian, Burton, Sharon P, Cook, Anthony L, Crosbie, Ewan C, Fenn, Marta A, Ferrare, Richard A, Freeman, Sean W, Hair, John W, Harper, David B, Hostetler, Chris A, Robinson, Claire E, Scarino, Amy Jo, Shook, Michael A, Sokolowsky, G Alexander, Susan C van den Heever, Winstead, Edward L, Woods, Sarah, Ziemba, Luke D, Sorooshian, Armin

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International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research... von Michelena, Hector I., Della Corte, Alessandro, Evangelista, Arturo, Maleszewski, Joseph J., Edwards, William D., Roman, Mary J., Devereux, Richard B., Fernández, Borja, Asch, Federico M., Barker, Alex J., Sierra-Galan, Lilia M., De Kerchove, Laurent, Fernandes, Susan M., Fedak, Paul W.M., Girdauskas, Evaldas, Delgado, Victoria, Abbara, Suhny, Lansac, Emmanuel, Prakash, Siddharth K., Bissell, Malenka M., Popescu, Bogdan A., Hope, Michael D., Sitges, Marta, Thourani, Vinod H., Pibarot, Phillippe, Chandrasekaran, Krishnaswamy, Lancellotti, Patrizio, Borger, Michael A., Forrest, John K., Webb, John, Milewicz, Dianna M., Makkar, Raj, Leon, Martin B., Sanders, Stephen P., Markl, Michael, Ferrari, Victor A., Roberts, William C., Song, Jae-Kwan, Blanke, Philipp, White, Charles S., Siu, Samuel, Svensson, Lars G., Braverman, Alan C., Bavaria, Joseph, Sundt, Thoralf M., El Khoury, Gebrine, De Paulis, Ruggero, Enriquez-Sarano, Maurice, Bax, Jeroen J., Otto, Catherine M., Schäfers, Hans-Joachim

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Genomic basis for RNA alterations in cancer von Calabrese, Claudia, Davidson, Natalie R., Demircioğlu, Deniz, Fonseca, Nuno A., He, Yao, Kahles, André, Lehmann, Kjong-Van, Liu, Fenglin, Shiraishi, Yuichi, Soulette, Cameron M., Urban, Lara, Greger, Liliana, Li, Siliang, Liu, Dongbing, Perry, Marc D., Xiang, Qian, Zhang, Fan, Zhang, Junjun, Bailey, Peter, Erkek, Serap, Hoadley, Katherine A., Hou, Yong, Huska, Matthew R., Kilpinen, Helena, Korbel, Jan O., Marin, Maximillian G., Markowski, Julia, Nandi, Tannistha, Pan-Hammarström, Qiang, Pedamallu, Chandra Sekhar, Siebert, Reiner, Stark, Stefan G., Su, Hong, Tan, Patrick, Waszak, Sebastian M., Yung, Christina, Zhu, Shida, Awadalla, Philip, Creighton, Chad J., Meyerson, Matthew, Ouellette, B. F. Francis, Wu, Kui, Yang, Huanming, Brazma, Alvis, Brooks, Angela N., Göke, Jonathan, Rätsch, Gunnar, Schwarz, Roland F., Stegle, Oliver, Zhang, Zemin

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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition von Rodriguez-Martin, Bernardo, Alvarez, Eva G., Baez-Ortega, Adrian, Zamora, Jorge, Supek, Fran, Demeulemeester, Jonas, Santamarina, Martin, Ju, Young Seok, Temes, Javier, Garcia-Souto, Daniel, Detering, Harald, Li, Yilong, Rodriguez-Castro, Jorge, Dueso-Barroso, Ana, Bruzos, Alicia L., Dentro, Stefan C., Blanco, Miguel G., Contino, Gianmarco, Ardeljan, Daniel, Tojo, Marta, Roberts, Nicola D., Zumalave, Sonia, Edwards, Paul A., Weischenfeldt, Joachim, Puiggròs, Montserrat, Chong, Zechen, Chen, Ken, Lee, Eunjung Alice, Wala, Jeremiah A., Raine, Keiran M., Butler, Adam, Waszak, Sebastian M., Navarro, Fabio C. P., Schumacher, Steven E., Monlong, Jean, Maura, Francesco, Bolli, Niccolo, Bourque, Guillaume, Gerstein, Mark, Park, Peter J., Wedge, David C., Beroukhim, Rameen, Torrents, David, Korbel, Jan O., Martincorena, Iñigo, Fitzgerald, Rebecca C., Van Loo, Peter, Kazazian, Haig H., Burns, Kathleen H., Campbell, Peter J., Tubio, Jose M. C.

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