ADME/PK as part of a rational approach to drug discovery von Eddershaw, Peter J, Beresford, Alan P, Bayliss, Martin K

Volltext

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors von Zhao, Yuan H., Le, Joelle, Abraham, Michael H., Hersey, Anne, Eddershaw, Peter J., Luscombe, Chris N., Boutina, Darko, Beck, Gordon, Sherborne, Brad, Cooper, Ian, Platts, James A.

Volltext

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6 substrate metabolism von LEWIS, D. F. V, EDDERSHAW, P. J, GOLDFARB, P. S, TARBIT, M. H

Volltext

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate von Lewis, D.F.V., Eddershaw, P.J., Dickins, M., Tarbit, M.H., Goldfarb, P.S.

Volltext

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity von Lewis, D.F.V, Dickins, M, Lake, B.G, Eddershaw, P.J, Tarbit, M.H, Goldfarb, P.S

Volltext

Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals von Lewis, D. F. V., Eddershaw, P. J., Goldfarb, P. S., Tarbit, M. H.

Volltext

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site... von LEWIS, D. F. V, BIRD, M. G, DICKINS, M, LAKE, B. G, EDDERSHAW, P. J, TARBIT, M. H, GOLDFARB, P. S

Volltext

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily von LEWIS, D. F. V., DICKINS, M., WEAVER, R. J., EDDERSHAW, P. J., GOLDFARB, P. S., TARBIT, M. H.

Volltext

Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102 von Lewis, David F.V., Lake, Brian G., George, Stephen G., Dickins, Maurice, Eddershaw, Peter J., Tarbit, Michael H., Beresford, Alan P., Goldfarb, Peter S., Guengerich, F.Peter

Volltext

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrom... von LEWIS, D. F. V., LAKE, B. G., DICKINS, M., EDDERSHAW, P. J., TARBIT, M. H., GOLDFARB, P. S.

Volltext

First principles investigation of singly reduced cytochrome P450 von SEGALL, M. D., PAYNE, M. C., ELLIS, S. W., TUCKER, G. T., EDDERSHAW, P. J.

Volltext

Absorption and disposition of ranitidine hydrochloride in rat and dog von Eddershaw, P. J., Chadwick, A. P., Higton, D. M., Fenwick, S. H., Linacre, P., Jenner, W. N., Bell, J. A., Manchee, G. R.

Volltext

SB‐656104‐A, a novel selective 5‐HT7 receptor antagonist, modulates REM sleep in rats von Thomas, David R, Melotto, Sergio, Massagrande, Mario, Gribble, Andrew D, Jeffrey, Phillip, Stevens, Alexander J, Deeks, Nigel J, Eddershaw, Peter J, Fenwick, Susan H, Riley, Graham, Stean, Tania, Scott, Claire M, Hill, Matthew J, Middlemiss, Derek N, Hagan, Jim J, Price, Gary W, Forbes, Ian T

Volltext

Characterization of glucuronic acid conjugates of a novel angiotensin receptor antagonist von Bowers, Gary D., Eddershaw, Peter J., Hughes, Soraya Y., Manchee, Gary R., Oxford, Janet, Games, D. E.

Volltext

Advances in drug metabolism screening von Eddershaw, PJ, Dickins, M

Volltext

Advances in in vitro drug metabolism screening von Eddershaw, Peter J, Dickins, Maurice

Volltext

SB-656104-A, a novel selective 5-HT sub(7) receptor antagonist, modulates REM sleep in rats von Thomas, DR, Melotto, S, Massagrande, M, Gribble, AD, Jeffrey, P, Stevens, A J, Deeks, N J, Eddershaw, P J, Fenwick, SH, Riley, G, Stean, T, Scott, C M, Hill, MJ, Middlemiss, D N

Volltext

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrom... von Lewis, DFV, Lake, B G, Dickins, M, Eddershaw, P J, Tarbit, M H, Goldfarb, P S

Volltext

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrom... von LEWIS, D. F. V., LAKE, B. G., DICKINS, M., EDDERSHAW, P. J., TARBIT, M. H., GOLDFARB, P. S.

Volltext

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6substrate metabolism von LEWIS, D. F. V., EDDERSHAW, P. J., GOLDFARB, P. S., TARBIT, M. H.

Volltext