Conditional Deletion of Sost in MSC‐Derived Lineages Identifies Specific Cell‐Type Contributions to Bone Mass and B‐Cell Development von Yee, Cristal S, Manilay, Jennifer O, Chang, Jiun C, Hum, Nicholas R, Murugesh, Deepa K, Bajwa, Jamila, Mendez, Melanie E, Economides, Aris E, Horan, Daniel J, Robling, Alexander G, Loots, Gabriela G

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Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development: DELETION OF Sost IN MSC-DERIVED LINEAGES von Yee, Cristal S., Manilay, Jennifer O., Chang, Jiun C., Hum, Nicholas R., Murugesh, Deepa K., Bajwa, Jamila, Mendez, Melanie E., Economides, Aris E., Horan, Daniel J., Robling, Alexander G., Loots, Gabriela G.

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RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity von Pefanis, Evangelos, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Kazadi, David, Sun, Jianbo, Federation, Alexander, Chao, Jaime, Elliott, Oliver, Liu, Zhi-Ping, Economides, Aris N., Bradner, James E., Rabadan, Raul, Basu, Uttiya

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Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP von Souma, Tomokazu, Thomson, Benjamin R., Heinen, Stefan, Carota, Isabel Anna, Yamaguchi, Shinji, Onay, Tuncer, Liu, Pan, Ghosh, Asish K., Li, Chengjin, Eremina, Vera, Hong, Young-Kwon, Economides, Aris N., Vestweber, Dietmar, Peters, Kevin G., Jin, Jing, Quaggin, Susan E.

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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity von Akbari, Parsa, Gilani, Ankit, Sosina, Olukayode, Kosmicki, Jack A, Khrimian, Lori, Fang, Yi-Ya, Persaud, Trikaldarshi, Garcia, Victor, Sun, Dylan, Li, Alexander, Mbatchou, Joelle, Locke, Adam E, Benner, Christian, Verweij, Niek, Lin, Nan, Hossain, Sakib, Agostinucci, Kevin, Pascale, Jonathan V, Dirice, Ercument, Dunn, Michael, Kraus, William E, Shah, Svati H, Chen, Yii-Der I, Rotter, Jerome I, Rader, Daniel J, Melander, Olle, Still, Christopher D, Mirshahi, Tooraj, Carey, David J, Berumen-Campos, Jaime, Kuri-Morales, Pablo, Alegre-Díaz, Jesus, Torres, Jason M, Emberson, Jonathan R, Collins, Rory, Balasubramanian, Suganthi, Hawes, Alicia, Jones, Marcus, Zambrowicz, Brian, Murphy, Andrew J, Paulding, Charles, Coppola, Giovanni, Overton, John D, Reid, Jeffrey G, Shuldiner, Alan R, Cantor, Michael, Kang, Hyun M, Abecasis, Goncalo R, Karalis, Katia, Economides, Aris N, Marchini, Jonathan, Yancopoulos, George D, Sleeman, Mark W, Altarejos, Judith, Della Gatta, Giusy, Tapia-Conyer, Roberto, Schwartzman, Michal L, Baras, Aris, Ferreira, Manuel A R, Lotta, Luca A

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Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression von Sebastian, Aimy, Chang, Jiun C, Mendez, Melanie E, Murugesh, Deepa K, Hatsell, Sarah, Economides, Aris N, Christiansen, Blaine A, Loots, Gabriela G

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Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton von Canalis, Ernesto, Economides, Aris N, Gazzerro, Elisabetta

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Targeted deletion of Sost distal enhancer increases bone formation and bone mass von Collette, Nicole M, Genetos, Damian C, Economides, Aris N, Xie, LiQin, Shahnazari, Mohammad, Yao, Wei, Lane, Nancy E, Harland, Richard M, Loots, Gabriela G

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Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide von Gonzaga-Jauregui, Claudia, Yesil, Gozde, Nistala, Harikiran, Gezdirici, Alper, Bayram, Yavuz, Nannuru, Kalyan C, Pehlivan, Davut, Yuan, Bo, Jimenez, Johanna, Sahin, Yavuz, Paine, Ingrid S, Akdemir, Zeynep Coban, Rajamani, Saathyaki, Staples, Jeffrey, Dronzek, John, Howell, Kristen, Fatih, Jawid M, Smaldone, Silvia, Schlesinger, Alan E, Ramírez, Norman, Cornier, Alberto S, Kelly, Melissa A, Haber, Robert, Chim, Shek Man, Nieman, Kristy, Wu, Nan, Walls, Johnathon, Poueymirou, William, Siao, Chia-Jen, Sutton, V Reid, Williams, Marc S, Posey, Jennifer E, Gibbs, Richard A, Carlo, Simon, Tegay, David H, Economides, Aris N, Lupski, James R

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Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes von Akbari, Parsa, Sosina, Olukayode A., Bovijn, Jonas, Landheer, Karl, Nielsen, Jonas B., Kim, Minhee, Aykul, Senem, De, Tanima, Haas, Mary E., Hindy, George, Lin, Nan, Dinsmore, Ian R., Luo, Jonathan Z., Hectors, Stefanie, Geraghty, Benjamin, Germino, Mary, Panagis, Lampros, Parasoglou, Prodromos, Walls, Johnathon R., Halasz, Gabor, Atwal, Gurinder S., Jones, Marcus, LeBlanc, Michelle G., Still, Christopher D., Carey, David J., Giontella, Alice, Orho-Melander, Marju, Berumen, Jaime, Kuri-Morales, Pablo, Alegre-Díaz, Jesus, Torres, Jason M., Emberson, Jonathan R., Collins, Rory, Rader, Daniel J., Zambrowicz, Brian, Murphy, Andrew J., Balasubramanian, Suganthi, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan R., Cantor, Michael, Abecasis, Goncalo R., Ferreira, Manuel A. R., Sleeman, Mark W., Gusarova, Viktoria, Altarejos, Judith, Harris, Charles, Economides, Aris N., Idone, Vincent, Karalis, Katia, Della Gatta, Giusy, Mirshahi, Tooraj, Yancopoulos, George D., Melander, Olle, Marchini, Jonathan, Tapia-Conyer, Roberto, Locke, Adam E., Baras, Aris, Verweij, Niek, Lotta, Luca A.

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Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis von Zhou, Sirui, Sosina, Olukayode A., Bovijn, Jonas, Laurent, Laetitia, Sharma, Vasundhara, Akbari, Parsa, Forgetta, Vincenzo, Jiang, Lai, Kosmicki, Jack A., Banerjee, Nilanjana, Morris, John A., Oerton, Erin, Jones, Marcus, LeBlanc, Michelle G., Idone, Vincent, Overton, John D., Reid, Jeffrey G., Cantor, Michael, Abecasis, Goncalo R., Goltzman, David, Greenwood, Celia M. T., Langenberg, Claudia, Baras, Aris, Economides, Aris N., Ferreira, Manuel A. R., Hatsell, Sarah, Ohlsson, Claes, Richards, J. Brent, Lotta, Luca A.

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A lymphatic defect causes ocular hypertension and glaucoma in mice von Thomson, Benjamin R, Heinen, Stefan, Jeansson, Marie, Ghosh, Asish K, Fatima, Anees, Sung, Hoon-Ki, Onay, Tuncer, Chen, Hui, Yamaguchi, Shinji, Economides, Aris N, Flenniken, Ann, Gale, Nicholas W, Hong, Young-Kwon, Fawzi, Amani, Liu, Xiaorong, Kume, Tsutomu, Quaggin, Susan E

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MAPPIN: a method for annotating, predicting pathogenicity and mode of inheritance for nonsynonymous variants von Gosalia, Nehal, Economides, Aris N, Dewey, Frederick E, Balasubramanian, Suganthi

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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure von Henry, Albert, Roselli, Carolina, Sveinbjörnsson, Garðar, Fatemifar, Ghazaleh, Hedman, Åsa K., Morley, Michael P., Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Backman, Joshua D., Biggs, Mary L., Brandimarto, Jeffrey, Buckbinder, Leonard, Carey, David J., Chasman, Daniel I., Chen, Xu, Chung, Jonathan, Cook, James P., Delgado, Graciela E., Denaxas, Spiros, Dörr, Marcus, Dudley, Samuel C., Esko, Tõnu, Finan, Chris, Gottdiener, John S., Gross, Stefan, Guðbjartsson, Daníel F., Gutmann, Rebecca, Haggerty, Christopher M., Hyde, Craig L., Ingelsson, Erik, Jukema, J. Wouter, Kavousi, Maryam, Khaw, Kay-Tee, Kleber, Marcus E., Køber, Lars, Koekemoer, Andrea, Langenberg, Claudia, Lind, Lars, Lotta, Luca A., Luan, Jian’an, März, Winfried, Melander, Olle, Mordi, Ify R., Morgan, Thomas, Morris, Andrew D., Morris, Andrew P., Morrison, Alanna C., Nelson, Christopher P., Niessner, Alexander, Niiranen, Teemu, O’Donoghue, Michelle L., Owens, Anjali T., Parry, Helen M., Perola, Markus, Rice, Kenneth M., Ridker, Paul M., Rotter, Jerome I., Salo, Perttu, Salomaa, Veikko, Smelser, Diane T., Stender, Steen, Stott, David J., Tammesoo, Mari-Liis, Taylor, Kent D., Teder-Laving, Maris, Thorsteinsdottir, Unnur, Torp-Pedersen, Christian, Trompet, Stella, Tyl, Benoit, Uitterlinden, Andre G., Veluchamy, Abirami, Völker, Uwe, Voors, Adriaan A., Wareham, Nicholas J., Waterworth, Dawn, Weiss, Raul, Wiggins, Kerri L., Yerges-Armstrong, Laura M., Yu, Bing, Zannad, Faiez, Zhao, Jing Hua, Hemingway, Harry, McMurray, John J. V., Yang, Jian, Visscher, Peter M., Malarstig, Anders, Holm, Hilma, Sattar, Naveed, Holmes, Michael V., Cappola, Thomas P., Hingorani, Aroon D., Kuchenbaecker, Karoline, Ellinor, Patrick T., Smith, J. Gustav, Vasan, Ramachandran S., Swerdlow, Daniel I., Lumbers, R. Thomas

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Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy von Lai, Ka-Man V., Gonzalez, Michael, Poueymirou, William T., Kline, William O., Na, Erqian, Zlotchenko, Elizabeth, Stitt, Trevor N., Economides, Aris N., Yancopoulos, George D., Glass, David J.

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Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways von Krause, Carola, Korchynskyi, Olexandr, de Rooij, Karien, Weidauer, Stella E., de Gorter, David J.J., van Bezooijen, Rutger L., Hatsell, Sarah, Economides, Aris N., Mueller, Thomas D., Löwik, Clemens W.G.M., ten Dijke, Peter

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Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model von Ren, Yinshi, Han, Xianglong, Ho, Sunita P., Harris, Stephen E., Cao, Zhengguo, Economides, Aris N., Qin, Chunlin, Ke, Huazhu, Liu, Min, Feng, Jian Q.

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Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes von Mansour Aly, Dina, Dwivedi, Om Prakash, Prasad, Rashmi B., Käräjämäki, Annemari, Hjort, Rebecka, Thangam, Manonanthini, Åkerlund, Mikael, Mahajan, Anubha, Udler, Miriam S., Florez, Jose C., McCarthy, Mark I., Brosnan, Julia, Melander, Olle, Carlsson, Sofia, Hansson, Ola, Tuomi, Tiinamaija, Groop, Leif, Ahlqvist, Emma

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Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR Study von Dewey, Frederick E.

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Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor von Anderson, Keith D, Pan, Li, Yang, Xiao-man, Hughes, Virginia C, Walls, Johnathon R, Dominguez, Melissa G, Simmons, Mary V, Burfeind, Patricia, Xue, Yingzi, Wei, Yi, Macdonald, Lynn E, Thurston, Gavin, Daly, Christopher, Lin, Hsin Chieh, Economides, Aris N, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gale, Nicholas W

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