CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes von Evers, Bastiaan, Jastrzebski, Katarzyna, Heijmans, Jeroen P M, Grernrum, Wipawadee, Beijersbergen, Roderick L, Bernards, Rene

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Inducing and exploiting vulnerabilities for the treatment of liver cancer von Wang, Cun, Vegna, Serena, Jin, Haojie, Benedict, Bente, Lieftink, Cor, Ramirez, Christel, de Oliveira, Rodrigo Leite, Morris, Ben, Gadiot, Jules, Wang, Wei, du Chatinier, Aimée, Wang, Liqin, Gao, Dongmei, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Schepers, Arnout, Jochems, Fleur, Sanchez, Antonio Mulero, Mainardi, Sara, te Riele, Hein, Beijersbergen, Roderick L., Qin, Wenxin, Akkari, Leila, Bernards, René

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Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer von Wang, Cun, Jin, Haojie, Gao, Dongmei, Lieftink, Cor, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Wang, Liqin, Beijersbergen, Roderick L., Qin, Wenxin, Bernards, René

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High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer von Wang, Liqin, Leite de Oliveira, Rodrigo, Wang, Cun, Fernandes Neto, João M., Mainardi, Sara, Evers, Bastiaan, Lieftink, Cor, Morris, Ben, Jochems, Fleur, Willemsen, Lisa, Beijersbergen, Roderick L., Bernards, René

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Targeting homologous recombination repair defects in cancer von Evers, Bastiaan, Helleday, Thomas, Jonkers, Jos

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DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II von Steurer, Barbara, Janssens, Roel C., Geijer, Marit E., Aprile-Garcia, Fernando, Geverts, Bart, Theil, Arjan F., Hummel, Barbara, van Royen, Martin E., Evers, Bastiaan, Bernards, René, Houtsmuller, Adriaan B., Sawarkar, Ritwick, Marteijn, Jurgen

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ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors von Berns, Katrien, Caumanns, Joseph J., Hijmans, E. Marielle, Gennissen, Annemiek M. C., Severson, Tesa M., Evers, Bastiaan, Wisman, G. Bea A., Jan Meersma, Gert, Lieftink, Cor, Beijersbergen, Roderick L., Itamochi, Hiroaki, van der Zee, Ate G. J., de Jong, Steven, Bernards, René

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Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability von Geijer, Marit E., Zhou, Di, Selvam, Kathiresan, Steurer, Barbara, Mukherjee, Chirantani, Evers, Bastiaan, Cugusi, Simona, van Toorn, Marvin, van der Woude, Melanie, Janssens, Roel C., Kok, Yannick P., Gong, Wenzhi, Raams, Anja, Lo, Calvin S. Y., Lebbink, Joyce H. G., Geverts, Bart, Plummer, Dalton A., Bezstarosti, Karel, Theil, Arjan F., Mitter, Richard, Houtsmuller, Adriaan B., Vermeulen, Wim, Demmers, Jeroen A. A., Li, Shisheng, van Vugt, Marcel A. T. M., Lans, Hannes, Bernards, René, Svejstrup, Jesper Q., Ray Chaudhuri, Arnab, Wyrick, John J., Marteijn, Jurgen A.

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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs von Prahallad, Anirudh, Heynen, Guus J.J.E., Germano, Giovanni, Willems, Stefan M., Evers, Bastiaan, Vecchione, Loredana, Gambino, Valentina, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Bernards, Rene

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Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis von Desmet, Christophe J., Gallenne, Tristan, Prieur, Alexandre, Reyal, Fabien, Visser, Nils L., Wittner, Ben S., Smit, Marjon A., Geiger, Thomas R., Laoukili, Jamila, Iskit, Sedef, Rodenko, Boris, Zwart, Wilbert, Evers, Bastiaan, Horlings, Hugo, Ajouaou, Abderrahrim, Zevenhoven, John, van Vliet, Martin, Ramaswamy, Sridhar, Wessels, Lodewyk F. A., Peeper, Daniel S.

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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis von Derksen, Patrick W.B., Liu, Xiaoling, Saridin, Francis, van der Gulden, Hanneke, Zevenhoven, John, Evers, Bastiaan, van Beijnum, Judy R., Griffioen, Arjan W., Vink, Jacqueline, Krimpenfort, Paul, Peterse, Johannes L., Cardiff, Robert D., Berns, Anton, Jonkers, Jos

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Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin von Evers, Bastiaan, Drost, Rinske, Schut, Eva, de Bruin, Michiel, van der Burg, Eline, Derksen, Patrick W B, Holstege, Henne, Liu, Xiaoling, van Drunen, Ellen, Beverloo, H Berna, Smith, Graeme C M, Martin, Niall M B, Lau, Alan, O'Connor, Mark J, Jonkers, Jos

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Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance von Berns, Katrien, Sonnenblick, Amir, Gennissen, Annemiek, Brohée, Sylvain, Hijmans, E Marielle, Evers, Bastiaan, Fumagalli, Debora, Desmedt, Christine, Loibl, Sibylle, Denkert, Carsten, Neven, Patrick, Guo, Wei, Zhang, Fan, Knijnenburg, Theo A, Bosse, Tjalling, van der Heijden, Michiel S, Hindriksen, Sanne, Nijkamp, Wouter, Wessels, Lodewyk F A, Joensuu, Heikki, Mills, Gordon B, Beijersbergen, Roderick L, Sotiriou, Christos, Bernards, René

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Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform von Jastrzebski, Katarzyna, Evers, Bastiaan, Beijersbergen, Roderick L.

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Bmi1 Regulates Stem Cells and Proliferation and Differentiation of Committed Cells in Mammary Epithelium von Pietersen, Alexandra M., Evers, Bastiaan, Prasad, Asheeta A., Tanger, Ellen, Cornelissen-Steijger, Paulien, Jonkers, Jos, van Lohuizen, Maarten

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Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability von Geijer, Marit E., Zhou, Di, Selvam, Kathiresan, Steurer, Barbara, Mukherjee, Chirantani, Evers, Bastiaan, Cugusi, Simona, van Toorn, Marvin, van der Woude, Melanie, Janssens, Roel C., Kok, Yannick P., Gong, Wenzhi, Raams, Anja, Lo, Calvin S. Y., Lebbink, Joyce H. G., Geverts, Bart, Plummer, Dalton A., Bezstarosti, Karel, Theil, Arjan F., Mitter, Richard, Houtsmuller, Adriaan B., Vermeulen, Wim, Demmers, Jeroen A. A., Li, Shisheng, van Vugt, Marcel A. T. M., Lans, Hannes, Bernards, René, Svejstrup, Jesper Q., Ray Chaudhuri, Arnab, Wyrick, John J., Marteijn, Jurgen A.

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A High-Throughput Pharmaceutical Screen Identifies Compounds with Specific Toxicity against BRCA2-Deficient Tumors von EVERS, Bastiaan, SCHUT, Eva, JONKERS, Jos, VAN DER BURG, Eline, BRAUMULLER, Tanya M, EGAN, David A, HOLSTEGE, Henne, EDSER, Pauline, ADAMS, David J, WADE-MARTINS, Richard, BOUWMAN, Peter

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The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality von Evers, Bastiaan, Bernards, Rene, Beijersbergen, Roderick L

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Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Ox... von Loseva, Olga, Shubbar, Emman, Haghdoost, Siamak, Evers, Bastiaan, Helleday, Thomas, Harms-Ringdahl, Mats

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A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair von Herr, Patrick, Lundin, Cecilia, Evers, Bastiaan, Ebner, Daniel, Bauerschmidt, Christina, Kingham, Guy, Palmai-Pallag, Timea, Mortusewicz, Oliver, Frings, Oliver, Sonnhammer, Erik, Helleday, Thomas

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