ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers von BERGETHON, Kristin, SHAW, Alice T, MARK, Eugene J, BATTEN, Julie M, HAIQUAN CHEN, WILNER, Keith D, KWAK, Eunice L, CLARK, Jeffrey W, CARBONE, David P, HONGBIN JI, ENGELMAN, Jeffrey A, MINO-KENUDSON, Mari, IGNATIUS OU, Sai-Hong, PAO, William, IAFRATE, A. John, KATAYAMA, Ryohei, LOVLY, Christine M, MCDONALD, Nerina T, MASSION, Pierre P, SIWAK-TAPP, Christina, GONZALEZ, Adriana, RONG FANG

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Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer von Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S, Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G, Mussolin, Benedetta, Kwak, Eunice L, Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A, Robinson, Hayley E, Hong, Theodore S, Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A John, Bardelli, Alberto, Corcoran, Ryan B

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Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study von Camidge, D Ross, Dr, Bang, Yung-Jue, Prof, Kwak, Eunice L, MD, Iafrate, A John, MD, Varella-Garcia, Marileila, Prof, Fox, Stephen B, Prof, Riely, Gregory J, MD, Solomon, Benjamin, MBBS, Ou, Sai-Hong I, MD, Kim, Dong-Wan, Prof, Salgia, Ravi, Prof, Fidias, Panagiotis, MD, Engelman, Jeffrey A, MD, Gandhi, Leena, MD, Jänne, Pasi A, MD, Costa, Daniel B, MD, Shapiro, Geoffrey I, MD, LoRusso, Patricia, DO, Ruffner, Katherine, MD, Stephenson, Patricia, ScD, Tang, Yiyun, PhD, Wilner, Keith, PhD, Clark, Jeffrey W, MD, Shaw, Alice T, MD

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MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib von LENNERZ, Jochen K, KWAK, Eunice L, SALGIA, Ravi, BANG, Yung-Jue, CLARK, Jeffrey W, SOLOMON, Benjamin J, JOHN IAFRATE, A, ACKERMAN, Allison, MICHAEL, Michael, FOX, Stephen B, BERGETHON, Kristin, LAUWERS, Gregory Y, CHRISTENSEN, James G, WILNER, Keith D, HABER, Daniel A

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Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad‐Based Tumor Genotyping von Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias‐Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John

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Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK von SHAW, Alice T, YEAP, Beow Y, SETTLEMAN, Jeffrey, KOBAYASHI, Susumu, MARK, Eugene J, RODIG, Scott J, CHIRIEAC, Lucian R, KWAK, Eunice L, LYNCH, Thomas, IAFRATE, A. John, MINO-KENUDSON, Mari, DIGUMARTHY, Subba R, COSTA, Daniel B, HEIST, Rebecca S, SOLOMON, Benjamin, STUBBS, Hannah, ADMANE, Sonal, MCDERMOTT, Ultan

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Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis von Shaw, Alice T, Dr, Yeap, Beow Y, ScD, Solomon, Benjamin J, MD, Riely, Gregory J, MD, Gainor, Justin, MD, Engelman, Jeffrey A, MD, Shapiro, Geoffrey I, MD, Costa, Daniel B, MD, Ou, Sai-Hong I, MD, Butaney, Mohit, BS, Salgia, Ravi, Prof, Maki, Robert G, MD, Varella-Garcia, Marileila, Prof, Doebele, Robert C, MD, Bang, Yung-Jue, Prof, Kulig, Kimary, PhD, Selaru, Paulina, MSPH, Tang, Yiyun, PhD, Wilner, Keith D, PhD, Kwak, Eunice L, MD, Clark, Jeffrey W, MD, Iafrate, A John, MD, Camidge, D Ross, MD

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A protein and mRNA expression-based classification of gastric cancer von Setia, Namrata, Agoston, Agoston T, Han, Hye S, Mullen, John T, Duda, Dan G, Clark, Jeffrey W, Deshpande, Vikram, Mino-Kenudson, Mari, Srivastava, Amitabh, Lennerz, Jochen K, Hong, Theodore S, Kwak, Eunice L, Lauwers, Gregory Y

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Phase I Study of Neratinib in Combination With Temsirolimus in Patients With Human Epidermal Growth Factor Receptor 2–Dependent and Other Solid Tumors von GANDHI, Leena, BAHLEDA, Rastislav, KRYGOWSKI, Mizue, YALI LIANG, TURNBULL, Kathleen W, SHAPIRO, Geoffrey I, SORIA, Jean-Charles, TOLANEY, Sara M, KWAK, Eunice L, CLEARY, James M, PANDYA, Shuchi S, HOLLEBECQUE, Antoine, ABBAS, Richat, ANANTHAKRISHNAN, Revathi, BERKENBLIT, Anna

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Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations von Ahronian, Leanne G, Sennott, Erin M, Van Allen, Eliezer M, Wagle, Nikhil, Kwak, Eunice L, Faris, Jason E, Godfrey, Jason T, Nishimura, Koki, Lynch, Kerry D, Mermel, Craig H, Lockerman, Elizabeth L, Kalsy, Anuj, Gurski, Jr, Joseph M, Bahl, Samira, Anderka, Kristin, Green, Lisa M, Lennon, Niall J, Huynh, Tiffany G, Mino-Kenudson, Mari, Getz, Gad, Dias-Santagata, Dora, Iafrate, A John, Engelman, Jeffrey A, Garraway, Levi A, Corcoran, Ryan B

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Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors von TOLCHER, Anthony W, MESSERSMITH, Wells A, BOYLAN, John F, XU, Zhi-Xin, KA WANG, KOEHLER, Astrid, SONG, James, MIDDLETON, Steven A, DEUTSCH, Jonathan, DEMARIO, Mark, KURZROCK, Razelle, WHELER, Jennifer J, MIKULSKI, Stanislaw M, PAPADOPOULOS, Kyriakos P, KWAK, Eunice L, GIBBON, Darlene G, PATNAIK, Amita, FALCHOOK, Gerald S, DASARI, Arvind, SHAPIRO, Geoffrey I

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FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience von Faris, Jason E., Blaszkowsky, Lawrence S., McDermott, Shaunagh, Guimaraes, Alexander R., Szymonifka, Jackie, Huynh, Mai Anh, Ferrone, Cristina R., Wargo, Jennifer A., Allen, Jill N., Dias, Lauren E., Kwak, Eunice L., Lillemoe, Keith D., Thayer, Sarah P., Murphy, Janet E., Zhu, Andrew X., Sahani, Dushyant V., Wo, Jennifer Y., Clark, Jeffrey W., Fernandez‐del Castillo, Carlos, Ryan, David P., Hong, Theodore S.

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Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study von ZHU, Andrew X, SAHANI, Dushyant V, BHARGAVA, Pankaj, MEYERHARDT, Jeffrey, CLARK, Jeffrey W, KWAK, Eunice L, HEZEL, Aram F, MIKSAD, Rebecca, ABRAMS, Thomas A, ENZINGER, Peter C, FUCHS, Charles S, RYAN, David P, DUDA, Dan G, JAIN, Rakesh K, DI TOMASO, Emmanuelle, ANCUKIEWICZ, Marek, CATALANO, Onofrio A, SINDHWANI, Vivek, BLASZKOWSKY, Lawrence S, YOON, Sam S, LAHDENRANTA, Johanna

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Phase 1/2 study of everolimus in advanced hepatocellular carcinoma von Zhu, Andrew X., Abrams, Thomas A., Miksad, Rebecca, Blaszkowsky, Lawrence S., Meyerhardt, Jeffrey A., Zheng, Hui, Muzikansky, Alona, Clark, Jeffrey W., Kwak, Eunice L., Schrag, Deborah, Jors, Kathryn R., Fuchs, Charles S., Iafrate, A. John, Borger, Darrell R., Ryan, David P.

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Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies von Schöffski, Patrick, Tan, Daniel S W, Martín, Miguel, Ochoa-de-Olza, María, Sarantopoulos, John, Carvajal, Richard D, Kyi, Chrisann, Esaki, Taito, Prawira, Amy, Akerley, Wallace, De Braud, Filippo, Hui, Rina, Zhang, Tian, Soo, Ross A, Maur, Michela, Weickhardt, Andrew, Krauss, Jürgen, Deschler-Baier, Barbara, Lau, Allen, Samant, Tanay S, Longmire, Tyler, Chowdhury, Niladri Roy, Sabatos-Peyton, Catherine A, Patel, Nidhi, Ramesh, Radha, Hu, Tiancen, Carion, Ana, Gusenleitner, Daniel, Yerramilli-Rao, Padmaja, Askoxylakis, Vasileios, Kwak, Eunice L, Hong, David S

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Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype von Hong, Theodore S, Wo, Jennifer Y, Borger, Darrell R, Yeap, Beow Y, McDonnell, Erin I, Willers, Henning, Blaszkowsky, Lawrence S, Kwak, Eunice L, Allen, Jill N, Clark, Jeffrey W, Tanguturi, Shyam, Goyal, Lipika, Murphy, Janet E, Wolfgang, John A, Drapek, Lorraine C, Arellano, Ronald S, Mamon, Harvey J, Mullen, John T, Tanabe, Kenneth K, Ferrone, Cristina R, Ryan, David P, Iafrate, A John, DeLaney, Thomas F, Zhu, Andrew X

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What’s the Best Way to Treat GE Junction Tumors? Approach Like Gastric Cancer von Mullen, John T., Kwak, Eunice L., Hong, Theodore S.

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Dose-Painted Intensity-Modulated Radiation Therapy for Anal Cancer: A Multi-Institutional Report of Acute Toxicity and Response to Therapy von Kachnic, Lisa A., M.D, Tsai, Henry K., M.D, Coen, John J., M.D, Blaszkowsky, Lawrence S., M.D, Hartshorn, Kevan, M.D, Kwak, Eunice L., M.D., Ph.D, Willins, John D., Ph.D, Ryan, David P., M.D, Hong, Theodore S., M.D

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Irreversible Inhibitors of the EGF Receptor May Circumvent Acquired Resistance to Gefitinib von Kwak, Eunice L., Sordella, Raffaella, Bell, Daphne W., Godin-Heymann, Nadia, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Driscoll, David R., Fidias, Panos, Lynch, Thomas J., Rabindran, Sridhar K., McGinnis, John P., Wissner, Allan, Sharma, Sreenath V., Isselbacher, Kurt J., Settleman, Jeffrey, Haber, Daniel A.

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A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies von Lin, Chia-Chi, Garralda, Elena, Schöffski, Patrick, Hong, David S., Siu, Lillian L., Martin, Miguel, Maur, Michela, Hui, Rina, Soo, Ross A, Chiu, Joanne, Zhang, Tian, Ma, Brigette, Kyi, Chrisann, Tan, Daniel SW, Cassier, Philippe A., Sarantopoulos, John, Weickhardt, Andrew, Carvajal, Richard D., Spratlin, Jennifer, Esaki, Taito, Rolland, Fréderic, Akerley, Wallace, Deschler-Baier, Barbara, Rispoli, Lawrence, Samant, Tanay S., Chowdhury, Niladri Roy, Gusenleitner, Daniel, Kwak, Eunice L., Askoxylakis, Vasileios, De Braud, Filippo

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