Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics von Nicolaou, K. C., Chen, Jason S., Edmonds, David J., Estrada, Anthony A.

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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib... von Vissers, Maurits F. J. M., Heuberger, Jules A. A. C., Groeneveld, Geert Jan, Oude Nijhuis, Jerome, De Deyn, Peter Paul, Hadi, Salah, Harris, Jeffrey, Tsai, Richard M., Cruz‐Herranz, Andres, Huang, Fen, Tong, Vincent, Erickson, Rebecca, Zhu, Yuda, Scearce‐Levie, Kimberly, Hsiao‐Nakamoto, Jennifer, Tang, Xinyan, Chang, Megan, Fox, Brian M., Estrada, Anthony A., Pomponio, Robert J., Alonso‐Alonso, Miguel, Zilberstein, Moshe, Atassi, Nazem, Troyer, Matthew D., Ho, Carole

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Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors von Estrada, Anthony A, Liu, Xingrong, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chan, Bryan K, Chen, Huifen, Ding, Xiao, DiPasquale, Antonio G, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Flynn, Sean, Fuji, Reina, Gill, Andrew, Gunzner-Toste, Janet, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Le Pichon, Claire E, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Mukund, Susmith, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Tran, Thuy, Trivedi, Naimisha, Wang, Shumei, Zhang, Shuo, Zhang, Xiaolin, Zhao, Guiling, Zhu, Haitao, Sweeney, Zachary K

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Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks von Nicolaou, K. C, Safina, Brian S, Zak, Mark, Lee, Sang Hyup, Nevalainen, Marta, Bella, Marco, Estrada, Anthony A, Funke, Christian, Zécri, Frédéric J, Bulat, Stephan

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Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis von Nicolaou, K. C, Zak, Mark, Safina, Brian S, Estrada, Anthony A, Lee, Sang Hyup, Nevalainen, Marta

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Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors von Estrada, Anthony A, Sweeney, Zachary K

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Total Synthesis of Thiostrepton, Part 2: Construction of the Quinaldic Acid Macrocycle and Final Stages of the Synthesis von Nicolaou, K. C., Zak, Mark, Safina, Brian S., Lee, Sang Hyup, Estrada, Anthony A.

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Total Synthesis of Thiostrepton, Part 1: Construction of the Dehydropiperidine/Thiazoline-Containing Macrocycle von Nicolaou, K. C., Safina, Brian S., Zak, Mark, Estrada, Anthony A., Lee, Sang Hyup

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Discovery of a Biologically Active Thiostrepton Fragment von Nicolaou, K. C, Zak, Mark, Rahimipour, Shai, Estrada, Anthony A, Lee, Sang Hyup, O'Brate, Aurora, Giannakakou, Paraskevi, Ghadiri, M. Reza

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Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease von Patel, Snahel, Meilandt, William J, Erickson, Rebecca I, Chen, Jinhua, Deshmukh, Gauri, Estrada, Anthony A, Fuji, Reina N, Gibbons, Paul, Gustafson, Amy, Harris, Seth F, Imperio, Jose, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Lyssikatos, Joseph P, Ma, Changyou, Yin, Jianping, Lewcock, Joseph W, Siu, Michael

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A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide von Nicolaou, K. C., Estrada, Anthony A., Zak, Mark, Lee, Sang Hyup, Safina, Brian S.

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Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases von Craig, Robert A., De Vicente, Javier, Estrada, Anthony A., Feng, Jianwen A., Lexa, Katrina W., Canet, Mark J., Dowdle, William E., Erickson, Rebecca I., Flores, Brittany N., Haddick, Patrick C. G., Kane, Lesley A., Lewcock, Joseph W., Moerke, Nathan J., Poda, Suresh B., Sweeney, Zachary, Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Yulyaningsih, Ernie, Solanoy, Hilda, Scearce-Levie, Kimberly, Sanchez, Pascal E., Tang, Liwei, Xu, Musheng, Zhang, Rui, Osipov, Maksim

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Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors von Estrada, Anthony A, Chan, Bryan K, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chen, Huifen, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Fuji, Reina, Gill, Andrew, Halladay, Jason, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Pichon, Claire E. Le, Liu, Xingrong, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Wong, Susan, Zhang, Shuo, Zhang, Xiaolin, Zhu, Haitao, Sweeney, Zachary K

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Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models von Patel, Snahel, Cohen, Frederick, Dean, Brian J., De La Torre, Kelly, Deshmukh, Gauri, Estrada, Anthony A., Ghosh, Arundhati Sengupta, Gibbons, Paul, Gustafson, Amy, Huestis, Malcolm P., Le Pichon, Claire E., Lin, Han, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Ly, Cuong Q., Lyssikatos, Joseph P., Ma, Changyou, Scearce-Levie, Kimberly, Shin, Young G., Solanoy, Hilda, Stark, Kimberly L., Wang, Jian, Wang, Bei, Zhao, Xianrui, Lewcock, Joseph W., Siu, Michael

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Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling von Chen, Huifen, Chan, Bryan K, Drummond, Jason, Estrada, Anthony A, Gunzner-Toste, Janet, Liu, Xingrong, Liu, Yichin, Moffat, John, Shore, Daniel, Sweeney, Zachary K, Tran, Thuy, Wang, Shumei, Zhao, Guiling, Zhu, Haitao, Burdick, Daniel J

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Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modelin... von Chen, Huifen, Volgraf, Matthew, Do, Steven, Kolesnikov, Aleksandr, Shore, Daniel G, Verma, Vishal A, Villemure, Elisia, Wang, Lan, Chen, Yong, Hu, Baihua, Lu, Ai-Jun, Wu, Guosheng, Xu, Xiaofeng, Yuen, Po-wai, Zhang, Yamin, Erickson, Shawn D, Dahl, Martin, Brotherton-Pleiss, Christine, Tay, Suzanne, Ly, Justin Q, Murray, Lesley J, Chen, Jun, Amm, Desiree, Lange, Wienke, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Lyssikatos, Joseph P, Safina, Brian S, Estrada, Anthony A

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Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2 von Shore, Daniel G.M., Sweeney, Zachary K., Beresford, Alan, Chan, Bryan K., Chen, Huifen, Drummond, Jason, Gill, Andrew, Kleinheinz, Tracy, Liu, Xingrong, Medhurst, Andrew D., McIver, Edward G., Moffat, John G., Zhu, Haitao, Estrada, Anthony A.

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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress res... von Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick C G, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandman, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

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α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists von Verma, Vishal A., Shore, Daniel G.M., Chen, Huifen, Chen, Jun, Do, Steven, Hackos, David H., Kolesnikov, Aleks, Lyssikatos, Joseph P., Tay, Suzanne, Wang, Lan, Estrada, Anthony A.

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New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems von Nicolaou, K.C., Estrada, Anthony A., Freestone, Graeme C., Lee, Sang Hyup, Alvarez-Mico, Xavier

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