Optimizing Early Clinical Investigations in Cancer Immunotherapy: The Translational Journey of RG6292, a Novel, Selective Treg‐Depleting Antibody von Belli, Sara, Amann, Maria, Hutchinson, Lucy, Pousse, Laurène, Abdolzade‐Bavil, Afsaneh, Justies, Nicole, Jacobsen, Bjoern, Ploix, Corinne, Tselempi, Eleni, Tosevski, Vinko, Koll, Hans, Schnetzler, Gabriel, Boetsch, Christophe, Marrer‐Berger, Estelle

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The physiological interactome of TCR-like antibody therapeutics in human tissues von Marrer-Berger, Estelle, Nicastri, Annalisa, Augustin, Angelique, Kramar, Vesna, Liao, Hanqing, Hanisch, Lydia Jasmin, Carpy, Alejandro, Weinzierl, Tina, Durr, Evelyne, Schaub, Nathalie, Nudischer, Ramona, Ortiz-Franyuti, Daniela, Breous-Nystrom, Ekaterina, Stucki, Janick, Hobi, Nina, Raggi, Giulia, Cabon, Lauriane, Lezan, Emmanuelle, Umaña, Pablo, Woodhouse, Isaac, Bujotzek, Alexander, Klein, Christian, Ternette, Nicola

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Abstract 6135: Tumor-bearing non-human primates: An unrivaled model for translational cancer immunology research von Ceppi, Maurizio, Hettich, Michael, Teichgräber, Volker, Driessen, Wouter, Tuerck, Dietrich, Marrer-Berger, Estelle, Evers, Stefan, Crameri, Flavio, Gomes, Bruno, Bachl, Jürgen, Klein, Christian, Claus, Christina, Amann, Maria, Krieter, Oliver, Dugan, Greg, Caudell, David, Grayson, Jason, Kiran, Sai Kumar Solingapuram, Cline, Mark

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Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies von Leclercq, Gabrielle, Haegel, Hélène, Schneider, Anneliese, Giusti, Anna Maria, Marrer-Berger, Estelle, Boetsch, Christophe, Walz, Antje-Christine, Pulko, Vesna, Sam, Johannes, Challier, John, Ferlini, Cristiano, Odermatt, Alex, Umaña, Pablo, Bacac, Marina, Klein, Christian

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Patient-derived micro-organospheres enable clinical precision oncology von Ding, Shengli, Hsu, Carolyn, Wang, Zhaohui, Natesh, Naveen R., Millen, Rosemary, Negrete, Marcos, Giroux, Nicholas, Rivera, Grecia O., Dohlman, Anders, Bose, Shree, Rotstein, Tomer, Spiller, Kassandra, Yeung, Athena, Sun, Zhiguo, Jiang, Chongming, Xi, Rui, Wilkin, Benjamin, Randon, Peggy M., Williamson, Ian, Nelson, Daniel A., Delubac, Daniel, Oh, Sehwa, Rupprecht, Gabrielle, Isaacs, James, Jia, Jingquan, Chen, Chao, Shen, John Paul, Kopetz, Scott, McCall, Shannon, Smith, Amber, Gjorevski, Nikolche, Walz, Antje-Christine, Antonia, Scott, Marrer-Berger, Estelle, Clevers, Hans, Hsu, David, Shen, Xiling

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Cytokine Release Syndrome By T-cell-Redirecting Therapies: Can We Predict and Modulate Patient Risk? von Van De Vyver, Arthur J, Marrer-Berger, Estelle, Wang, Ken, Lehr, Thorsten, Walz, Antje-Christine

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Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies von Kroll, Katharina T, Mata, Mariana M, Homan, Kimberly A, Micallef, Virginie, Carpy, Alejandro, Hiratsuka, Ken, Morizane, Ryuji, Moisan, Annie, Gubler, Marcel, Walz, Antje-Christine, Marrer-Berger, Estelle, Lewis, Jennifer A

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Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody von Augsberger, Christian, Hänel, Gerulf, Xu, Wei, Pulko, Vesna, Hanisch, Lydia Jasmin, Augustin, Angelique, Challier, John, Hunt, Katharina, Vick, Binje, Rovatti, Pier Eduardo, Krupka, Christina, Rothe, Maurine, Schönle, Anne, Sam, Johannes, Lezan, Emmanuelle, Ducret, Axel, Ortiz-Franyuti, Daniela, Walz, Antje-Christine, Benz, Jörg, Bujotzek, Alexander, Lichtenegger, Felix S., Gassner, Christian, Carpy, Alejandro, Lyamichev, Victor, Patel, Jigar, Konstandin, Nikola, Tunger, Antje, Schmitz, Marc, von Bergwelt-Baildon, Michael, Spiekermann, Karsten, Vago, Luca, Jeremias, Irmela, Marrer-Berger, Estelle, Umaña, Pablo, Klein, Christian, Subklewe, Marion

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Micro-organospheres retain patient tumor microenvironment for precision immuno-oncology von Ding, Shengli, Natesh, Naveen R., Spiller, Kassandra, Xi, Rui, Nelson, Daniel, Gjorevski, Nikolche, Walz, Antje, Marrer-Berger, Estelle, Clevers, Hans, Hsu, Shiaowen David, Shen, Xiling

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The physiological interactome of TCR-like antibody therapeutics in human tissues von Marrer-Berger, Estelle, Nicastri, Annalisa, Augustin, Angelique, Kramar, Vesna, Liao, Hanqing, Hanisch, Lydia Jasmin, Carpy, Alejandro, Weinzierl, Tina, Durr, Evelyne, Schaub, Nathalie, Nudischer, Ramona, Ortiz-Franyuti, Daniela, Breous-Nystrom, Ekaterina, Stucki, Janick, Hobi, Nina, Raggi, Giulia, Cabon, Lauriane, Lezan, Emmanuelle, Umaña, Pablo, Woodhouse, Isaac, Bujotzek, Alexander, Klein, Christian, Ternette, Nicola

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CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity von Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y, Ghorani, Ehsan, Akarca, Ayse U, Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S, Quezada, Sergio A

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CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity von Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y., Ghorani, Ehsan, Akarca, Ayse U., Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S., Quezada, Sergio A.

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Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment von Brennan, Frank R., Cavagnaro, Joy, McKeever, Kathleen, Ryan, Patricia C., Schutten, Melissa M., Vahle, John, Weinbauer, Gerhard F., Marrer-Berger, Estelle, Black, Lauren E.

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Abstract 4553: The CD25 antibody RG6292 selectively depletes Tregs while preserving IL-2 signaling and CTL activity for tumor control von Amann, Maria, Schnetzler, Gabriel, Theresa, Kolben, Solomon, Isabelle, Boetsch, Christophe, Marrer-Berger, Estelle, Flury, Reto, Murgia, Claudio, Karanikas, Vaios, Sam, Johannes, Sutmuller, Roger, Eckmann, Jan, Koll, Hans, Belli, Sara, Vargas, Frederic Arce, Zervas, Dimitrios, Qing, Chen, Brown, Mark A., Salimu, Josephine, Goubier, Anne, Neumann, Sebastian, Peggs, Karl S., Quezada, Sergio A.

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Transforming preclinical assessment to meet clinical relevance with advanced models von Breous-Nystrom, Ekaterina, Kronenberg, Sven, Marrer-Berger, Estelle, Roth, Adrian, Lave, Thierry, Singer, Thomas

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Gut Microbiota Is Associated with Onset and Severity of Type 1 Diabetes in Nonobese Diabetic Mice Treated with Anti-PD-1 von Patel, Shriram, Becker, Eugenia, Ploix, Corinne, Steiner, Guido, Scepanovic, Petar, Fueth, Matthias, de Vera Mudry, Maria Cristina, Eichinger-Chapelon, Anne, Marrer-Berger, Estelle, Claesson, Marcus J

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653 Dasatinib as a rapid pharmacological ON/OFF switch for T cell bispecific antibody-induced T cell activation and cytokine release von Leclercq, Gabrielle, Haegel, Helene, Schneider, Anneliese, Berger, Estelle Marrer, Walz, Antje, Boetsch, Christophe, Pulko, Vesna, Ferlini, Cristiano, Klein, Christian

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ANTIBODIES BINDING TO HLA-A2/MAGE-A4 von WEINZIERL, Tina, HANISCH, Lydia Jasmin, KLEIN, Christian, CARPY GUTIERREZ CIRLOS, Alejandro, KLOSTERMANN, Stefan, UMAÑA, Pablo, KEISER, Simon Patrick, BUJOTZEK, Alexander, FAUTI, Tanja, MARRER-BERGER, Estelle

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HLA-A2/MAGE-A4에 결합하는 항체 von HANISCH LYDIA JASMIN, MARRER BERGER ESTELLE, CARPY GUTIERREZ CIRLOS ALEJANDRO, KLEIN CHRISTIAN, FAUTI TANJA, WEINZIERL TINA, KLOSTERMANN STEFAN, UMANA PABLO, BUJOTZEK ALEXANDER, KEISER SIMON PATRICK

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Antibodies binding to HLA-A2/MAGE-A4 von Klostermann, Stefan, Hanisch, Lydia Jasmin, Marrer-Berger, Estelle, Carpy Gutierrez Cirlos, Alejandro, Bujotzek, Alexander, Weinzierl, Tina, Fauti, Tanja, Klein, Christian, Umaña, Pablo, Keiser, Simon Patrick

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