Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Non... von Engstrom, Lars D, Aranda, Ruth, Lee, Matthew, Tovar, Elizabeth A, Essenburg, Curt J, Madaj, Zachary, Chiang, Harrah, Briere, David, Hallin, Jill, Lopez-Casas, Pedro P, Baños, Natalia, Menendez, Camino, Hidalgo, Manuel, Tassell, Vanessa, Chao, Richard, Chudova, Darya I, Lanman, Richard B, Olson, Peter, Bazhenova, Lyudmilla, Patel, Sandip Pravin, Graveel, Carrie, Nishino, Mizuki, Shapiro, Geoffrey I, Peled, Nir, Awad, Mark M, Jänne, Pasi A, Christensen, James G

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Ex Vivo Patient-Derived Explant Model for Neurofibromatosis Type 1–Related Cutaneous Neurofibromas von Grit, Jamie L., Turner, Lisa, Essenburg, Curt J., Gallik, Kristin L., Dischinger, Patrick S., Shurlow, Nathan D., Pate, Matthew J., Graveel, Carrie R., Steensma, Matthew R.

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Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling von Grit, Jamie L., Johnson, Benjamin K., Dischinger, Patrick S., J. Essenburg, Curt, Adams, Marie, Campbell, Stacy, Pollard, Kai, Pratilas, Christine A., Triche, Tim J., Graveel, Carrie R., Steensma, Matthew R.

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p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs von Grit, Jamie L., McGee, Lauren E., Tovar, Elizabeth A., Essenburg, Curt J., Wolfrum, Emily, Beddows, Ian, Williams, Kaitlin, Sheridan, Rachael T. C., Schipper, Joshua L., Adams, Marie, Arumugam, Menusha, Vander Woude, Thomas, Gurunathan, Sharavana, Field, Jeffrey M., Wulfkuhle, Julia, Petricoin, Emanuel F., Graveel, Carrie R., Steensma, Matthew R.

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NF1 deficiency drives metabolic reprogramming in ER+ breast cancer von House, Rachel (Rae) J., Tovar, Elizabeth A., Redlon, Luke N., Essenburg, Curt J., Dischinger, Patrick S., Ellis, Abigail E., Beddows, Ian, Sheldon, Ryan D., Lien, Evan C., Graveel, Carrie R., Steensma, Matthew R.

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Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma von Xie, Qian, Bradley, Robert, Kang, Liang, Koeman, Julie, Ascierto, Maria Libera, Worschech, Andrea, De Giorgi, Valeria, Wang, Ena, Kefene, Lisa, Su, Yanli, Essenburg, Curt, Kaufman, Dafna W, DeKoning, Tom, Enter, Mark A, O'Rourke, Timothy J, Marincola, Francesco M, Vande Woude, George F

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Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta von Wilson, Mike R., Holladay, Jeanne, Sheridan, Rachael, Hostetter, Galen, Berghuis, Bree, Graveel, Carrie, Essenburg, Curt, Peck, Anderson, Ho, Thai H., Stanton, Melissa, Chandler, Ronald L.

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Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities von Grit, Jamie L., Pridgeon, Matt G., Essenburg, Curt J., Wolfrum, Emily, Madaj, Zachary B., Turner, Lisa, Wulfkuhle, Julia, Petricoin, Emanuel F., Graveel, Carrie R., Steensma, Matthew R.

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Abstract PO-115: Defining mechanisms of resistance in NF1-related malignant peripheral nerve sheath tumors von McGee, Lauren, Grit, Jamie, Essenburg, Curt, Graveel, Carrie, Steensma, Matt

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Abstract A018: YAP signaling promotes resistance to MEK and AKT inhibition in NF1-related MPNSTs von McGee, Lauren, Essenburg, Curt, Turner, Lisa, Hirbe, Angela, Dey, Anwesha, Zbieg, Jason, Graveel, Carrie, Steensma, Matt

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Abstract A48: MET and EGFR interaction promotes acquired resistance to kinase inhibition in TNBC von Tovar, Elizabeth, Essenburg, Curt, Peck, Anderson, Turner, Lisa, Madaj, Zachary, Smith, Matthew, Christensen, James, Melnik, Marianne, Haura, Eric, Steensma, Matthew, Graveel, Carrie

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MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor―Dependent Fashion to Suppress Carcinoma Growth von ZHANG, Yu-Wen, STAAL, Ben, VANDE WOUDE, George F, ESSENBURG, Curt, YANLI SU, LIANG KANG, WEST, Rich, KAUFMAN, Dafna, DEKONING, Tom, EAGLESON, Bryn, BUCHANAN, Sean G

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Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFR von Zhang, Yu-Wen, Staal, Ben, Essenburg, Curt, Lewis, Steven, Kaufman, Dafna, Vande Woude, George F

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Abstract B43: NF1 deficiency induces aggressive mammary carcinomas in a CRISPR rat model and correlates with poor outcome in sporadic human breast cancer von Dischinger, Patrick, Tovar, Elizabeth, Essenburg, Curt, Gardner, Eve, Callaghan, Megan, Bowman, Megan, Madaj, Zachary, Turner, Ashley, Challa, Anil, Kempston, Tristan, Eagleson, Bryn, Bronson, Roderick, Kesterson, Robert, Steensma, Matthew, Graveel, Carrie

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Abstract 2167: Strengthening anti-cancer effects on non-small cell lung carcinoma by dual blockage of MET and EGFR in a context-dependent manner von Zhang, Yu-Wen, Staal, Ben, Essenburg, Curt, Lewis, Steven, Kaufman, Dafna, Vande Woude, George F.

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Overexpression of HGF Promotes HBV-Induced Hepatocellular Carcinoma Progression and Is an Effective Indicator for Met-Targeting Therapy von Xie, Qian, Su, Yanli, Dykema, Karl, Johnson, Jennifer, Koeman, Julie, De Giorgi, Valeria, Huang, Alan, Schlegel, Robert, Essenburg, Curt, Kang, Liang, Iwaya, Keiichi, Seki, Shuhji, Khoo, Sok Kean, Zhang, Boheng, Buonaguro, Franco, Marincola, Francesco M, Furge, Kyle, Vande Woude, George F, Shinomiya, Nariyoshi

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Abstract LB-223: Dissecting the therapeutic determinants of MET inhibition in Glioblastoma: HGF-autocrine loop predicts sensitivity to MET inhibitor von Xie, Qian, Bradley, Robert, Kang, Liang, Koeman, Julie, Worschech, Andrea, De Giorgi, Valeria, Wang, Ena, Kefene, Lisa, Su, Yanli, Essenburg, Curt, Kaufman, Dafna, DeKoning, Tom, Enter, Mark, J.O'Rourke, Timothy, Marincola, Francesco, Vande Woude, George F.

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Additional file 6 of Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling von Grit, Jamie L., Johnson, Benjamin K., Dischinger, Patrick S., Essenburg, Curt J., Adams, Marie, Campbell, Stacy, Pollard, Kai, Pratilas, Christine A., Triche, Tim J., Graveel, Carrie R., Steensma, Matthew R.

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