How cell death shapes cancer von Labi, V, Erlacher, M

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BH3-only proteins in cell death initiation, malignant disease and anticancer therapy von Labi, V, Erlacher, M, Kiessling, S, Villunger, A

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P816: TRANSIENT MONOSOMY 7 IN SAMD9/9L SYNDROMES: IS IT SAFE TO WATCH AND WAIT? von Erlacher, M., Andresen, F., Yoshimi, A., Sukova, M., Stary, J., Moerloose, B., Dworzak, M., Polychronopoulou, S., Göhring, G., Kratz, C., Werff ten Bosch, J., Seidel, M., Strahm, B., Wlodarski, M., Niemeyer, C.

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S274: A NOVEL SUBTYPE OF ANEMIA CAUSED BY MUTATIONS IN TFRC GENE von Colucci, S., Venturi, V., Nicole, F., Jové Solavera, D., Zimon, M., Richter‐Pechanska, P., Hernandez, G., Unal, S., Gumruk, F., Diaz‐Conradi, A., Romero‐Cortadellas, L., Ferrer‐Cortès, X., Olivella, M., Erlacher, M., Niemeyer, C., Wiesel, T., Pepperkok, R., Fleming, M. D., Kulozik, A. E., Sanchez, M., Muckenthaler, M. U.

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intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination von Amort, Melanie, Wotzel, Brigitte, Bakowska-Zywicka, Kamilla, Erlacher, Matthias D, Micura, Ronald, Polacek, Norbert

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Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7 von Pastor, Victor B, Sahoo, Sushree S, Boklan, Jessica, Schwabe, Georg C, Saribeyoglu, Ebru, Strahm, Brigitte, Lebrecht, Dirk, Voss, Matthias, Bryceson, Yenan T, Erlacher, Miriam, Ehninger, Gerhard, Niewisch, Marena, Schlegelberger, Brigitte, Baumann, Irith, Achermann, John C, Shimamura, Akiko, Hochrein, Jochen, Tedgård, Ulf, Nilsson, Lars, Hasle, Henrik, Boerries, Melanie, Busch, Hauke, Niemeyer, Charlotte M, Wlodarski, Marcin W

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Chemical engineering of the peptidyl transferase center reveals an important role of the 2′-hydroxyl group of A2451 von Erlacher, Matthias D., Lang, Kathrin, Shankaran, Nisha, Wotzel, Brigitte, Hüttenhofer, Alexander, Micura, Ronald, Mankin, Alexander S., Polacek, Norbert

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Pitot-tube flowmeter for quantification of airflow during sleep von Kirkness, J P, Verma, M, McGinley, B M, Erlacher, M, Schwartz, A R, Smith, P L, Wheatley, J R, Patil, S P, Amis, T C, Schneider, H

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BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo von Erlacher, Miriam, Michalak, Ewa M., Kelly, Priscilla N., Labi, Verena, Niederegger, Harald, Coultas, Leigh, Adams, Jerry M., Strasser, Andreas, Villunger, Andreas

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Death squads enlisted by the tumour suppressor p53 von Michalak, Ewa, Villunger, Andreas, Erlacher, Miriam, Strasser, Andreas

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Topic: AS04-MDS Biology and Pathogenesis/AS04c-MDS Mouse models (GEMMS, PDX) von Fernandez-Orth, J., Weiss, J., Geoffroy, A., Gonzalez-Mendez, I., Steinemann, D., Quintanilla-Martinez, L., Boerries, M., Niemeyer, C., Erlacher, M.

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O26 - Topic: AS04-MDS Biology and Pathogenesis/AS04c-MDS Mouse models (GEMMS, PDX): LEUKEMOGENESIS IN GATA2 HAPLOINSUFFICIENT MICE IS A SECONDARY EVENT AFTER BONE MARROW FAILURE von Fernandez-Orth, J., Weiss, J., Geoffroy, A., Gonzalez-Mendez, I., Steinemann, D., Quintanilla-Martinez, L., Boerries, M., Niemeyer, C., Erlacher, M.

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Topic: AS04-MDS Biology and Pathogenesis/AS04d-Somatic mutations: THE EVOLVING GENETIC LANDSCAPE OF PEDIATRIC MDS-EB von Erlacher, M., Yoshimi, A., Stasik, S., Ramamoorthy, S., Lebrecht, D., Noellke, P., Goehring, G., De Haas, V., Starý, J., Masetti, R., Ussowicz, M., Barzilai-Birenboim, S., De Moerloose, B., Kállay, K., Buechner, J., Dworzak, M., Catala, A., Hasle, H., Schmugge, M., Polychronopoulou, S., Boďová, I., Jahnukainen, K., Smith, O., Kavcic, M., Turkiewicz, D., Kjollerstrom, P., Locatelli, F., Wlodarski, M., Thiede, C., Strahm, B., Niemeyer, C.

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Novel findings in two patients with late-diagnosed afibrinogenaemia: intraosseous haemorrhage and fingertip necrosis von ERLACHER, M., HEISS, J., HAINMANN, I., UHL, M., BUDDE, U., OLDENBURG, J., IVASKEVICIUS, V., AL-JAMALI, J., ZAJONC, H., SUPERTI-FURGA, A., ZIEGER, B.

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P47 - Topic: AS07-Singular Entities/Subtypes/AS07c-Hereditary MDS including predisposition syndromes: HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN AND ADOLESCENTS WITH GATA2... von Bortnick, R., Wlodarski, M., De Haas, V., De Moerloose, B., Dworzak, M., Hasle, H., Masetti, R., Stary, J., Turkiewicz, D., Ussowicz, M., Kozyra, E., Albert, M., Bader, P., Bordon, V., Cario, G., Beier, R., Schulte, J., Bresters, D., Mueller, I., Pichler, H., Sedlacek, P., Sauer, M., Zecca, M., Göhring, G., Yoshimi, A., Noellke, P., Erlacher, M., Locatelli, F., Niemeyer, C., Strahm, B.

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Topic: AS07-Singular Entities/Subtypes/AS07c-Hereditary MDS including predisposition syndromes von Bortnick, R., Wlodarski, M., De Haas, V., De Moerloose, B., Dworzak, M., Hasle, H., Masetti, R., Stary, J., Turkiewicz, D., Ussowicz, M., Kozyra, E., Albert, M., Bader, P., Bordon, V., Cario, G., Beier, R., Schulte, J., Bresters, D., Mueller, I., Pichler, H., Sedlacek, P., Sauer, M., Zecca, M., Göhring, G., Yoshimi, A., Noellke, P., Erlacher, M., Locatelli, F., Niemeyer, C., Strahm, B.

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Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution von Sahoo, S., Pastor, V., Goodings, C., Noellke, P., Dworzak, M., Stary, J., Locatelli, F., Masetti, R., Schmugge, M., De Moerloose, B., Catala, A., Kállay, K., Turkiewicz, D., Hasle, H., Buechner, J., Jahnukainen, K., Ussowicz, M., Polychronopoulou, S., Smith, O., Fabri, O., Barzilai, S., De Haas, V., Baumann, I., Schwarz-Furlan, S., Göhring, G., Yoshimi, A., Flotho, C., Strahm, B., Erlacher, M., Niemeyer, C., Wlodarski, M.

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O05 - Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution: SOMATIC GENETIC RESCUE IN SAMD9/SAMD9L MDS PREDISPOSITION SYNDROMES von Sahoo, S., Pastor, V., Goodings, C., Noellke, P., Dworzak, M., Stary, J., Locatelli, F., Masetti, R., Schmugge, M., De Moerloose, B., Catala, A., Kállay, K., Turkiewicz, D., Hasle, H., Buechner, J., Jahnukainen, K., Ussowicz, M., Polychronopoulou, S., Smith, O., Fabri, O., Barzilai, S., De Haas, V., Baumann, I., Schwarz-Furlan, S., Göhring, G., Yoshimi, A., Flotho, C., Strahm, B., Erlacher, M., Niemeyer, C., Wlodarski, M.

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Topic: AS06-Prognosis/AS06b-Predictive factors of response to treatment von Yoshimi, A., Vinci, L., Flotho, C., Noellke, P., Erlacher, M., Lebrecht, D., Masetti, R., De Haas, V., De Moerloose, B., Dworzak, M., Hasle, H., Schmugge, M., Stary, J., Turkiewicz, D., Ussowicz, M., Catala, A., Buechner, J., Jahnukainen, K., Kállay, K., Fabri, O., Smith, O., Göhring, G., Locatelli, F., Strahm, B., Niemeyer, C.

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O27 - Topic: AS06-Prognosis/AS06b-Predictive factors of response to treatment: OUTCOMES OF RELAPSED JUVENILE MYELOMONOCYTIC LEUKEMIA: THE ROLE OF SECOND HEMATOPOIETIC STEM CELL TRA... von Yoshimi, A., Vinci, L., Flotho, C., Noellke, P., Erlacher, M., Lebrecht, D., Masetti, R., De Haas, V., De Moerloose, B., Dworzak, M., Hasle, H., Schmugge, M., Stary, J., Turkiewicz, D., Ussowicz, M., Catala, A., Buechner, J., Jahnukainen, K., Kállay, K., Fabri, O., Smith, O., Göhring, G., Locatelli, F., Strahm, B., Niemeyer, C.

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