Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations von Steinbrecher, Thomas, Zhu, Chongkai, Wang, Lingle, Abel, Robert, Negron, Christopher, Pearlman, David, Feyfant, Eric, Duan, Jianxin, Sherman, Woody

Volltext

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy von Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K

Volltext

A general approach to site-specific antibody drug conjugates von Tian, Feng, Lu, Yingchun, Manibusan, Anthony, Sellers, Aaron, Tran, Hon, Sun, Ying, Phuong, Trung, Barnett, Richard, Hehli, Brad, Song, Frank, DeGuzman, Michael J., Ensari, Semsi, Pinkstaff, Jason K., Sullivan, Lorraine M., Biroc, Sandra L., Ho Cho, Schultz, Peter G., DiJoseph, John, Dougher, Maureen, Ma, Dangshe, Dushin, Russell, Leal, Mauricio, Tchistiakova, Lioudmila, Feyfant, Eric, Gerber, Hans-Peter, Sapra, Puja

Volltext

Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology von Hughes, David J, Tiede, Christian, Penswick, Natalie, Tang, Anna Ah-San, Trinh, Chi H, Mandal, Upasana, Zajac, Katarzyna Z, Gaule, Thembaninskosi, Howell, Gareth, Edwards, Thomas A, Duan, Jianxin, Feyfant, Eric, McPherson, Michael J, Tomlinson, Darren C, Whitehouse, Adrian

Volltext

Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline von OLSON, Matthew W, RUZIN, Alexey, FEYFANT, Eric, RUSH, Thomas S, O'CONNELL, John, BRADFORD, Patricia A

Volltext

Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α‑Helical Peptide in Clinical Development von Guerlavais, Vincent, Sawyer, Tomi K., Carvajal, Luis, Chang, Yong S., Graves, Bradford, Ren, Jian-Guo, Sutton, David, Olson, Karen A., Packman, Kathryn, Darlak, Krzysztof, Elkin, Carl, Feyfant, Eric, Kesavan, Kamala, Gangurde, Pranoti, Vassilev, Lyubomir T., Nash, Huw M., Vukovic, Vojislav, Aivado, Manuel, Annis, D. Allen

Volltext

Identification of a New Member of the Tryptase Family of Mouse and Human Mast Cell Proteases Which Possesses a Novel COOH-terminal Hydrophobic Extension von Wong, Guang W., Tang, Yinzi, Feyfant, Eric, Šali, Andrej, Li, Lixin, Li, Yong, Huang, Chifu, Friend, Daniel S., Krilis, Steven A., Stevens, Richard L.

Volltext

Modeling mutations in protein structures von Feyfant, Eric, Sali, Andrej, Fiser, András

Volltext

Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing von Modi, Meera E., Majchrzak, Mark J., Fonseca, Kari R., Doran, Angela, Osgood, Sarah, Vanase-Frawley, Michelle, Feyfant, Eric, McInnes, Heather, Darvari, Ramin, Buhl, Derek L., Kablaoui, Natasha M.

Volltext

The Role of Bridging Water and Hydrogen Bonding as Key Determinants of Noncovalent Protein–Carbohydrate Recognition von Ruvinsky, Anatoly M., Aloni, Ishita, Cappel, Daniel, Higgs, Chris, Marshall, Kyle, Rotkiewicz, Piotr, Repasky, Matt, Feher, Victoria A., Feyfant, Eric, Hessler, Gerhard, Matter, Hans

Volltext

Development of an Informatics Platform for Therapeutic Protein and Peptide Analytics von Hansen, Mark R, Villar, Hugo O, Feyfant, Eric

Volltext

Generation of specific inhibitors of SUMO1- and SUMO2/3-mediated protein-protein interactions using Affimer (Adhiron) technology von Hughes, David J., Tiede, Christian, Penswick, Natalie, Tang, Anna A. S., Trinh, Chi H., Mandal, Upasana, Zajac, Katarzyna Z., Gaule, Thembaninskosi, Howell, Gareth, Edwards, Thomas A., Duan, Jianxin, Feyfant, Eric, McPherson, Michael J., Tomlinson, Darren C., Whitehouse, Adrian

Volltext

Mouse Mast Cell Protease 9, a Novel Member of the Chromosome 14 Family of Serine Proteases that is Selectively Expressed in Uterine Mast Cells von Hunt, John E., Friend, Daniel S., Gurish, Michael F., Feyfant, Eric, Šali, Andrej, Huang, Chifu, Ghildyal, Namit, Stechschulte, Stephen, Austen, K. Frank, Stevens, Richard L.

Volltext

Fragment-Based Drug Design von Feyfant, Eric, Cross, Jason B., Paris, Kevin, Tsao, Désirée H.H.

Volltext

CONFIRM: connecting fragments found in receptor molecules von Thompson, David C., Aldrin Denny, R., Nilakantan, Ramaswamy, Humblet, Christine, Joseph-McCarthy, Diane, Feyfant, Eric

Volltext

Stapled [alpha]-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy von Chang, Yong S, Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A, Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z, Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E, Horstick, James, Annis, D Allen, Manning, Anthony M, Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T, Sawyer, Tomi K

Volltext

Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy von Chang, Yong S., Graves, Bradford, Guerlavais, Vincent, Tovar, Christian, Packman, Kathryn, To, Kwong-Him, Olson, Karen A., Kesavan, Kamala, Gangurde, Pranoti, Mukherjee, Aditi, Baker, Theresa, Darlak, Krzysztof, Elkin, Carl, Filipovic, Zoran, Qureshi, Farooq Z., Cai, Hongliang, Berry, Pamela, Feyfant, Eric, Shi, Xiangguo E., Horstick, James, Annis, D. Allen, Manning, Anthony M., Fotouhi, Nader, Nash, Huw, Vassilev, Lyubomir T., Sawyer, Tomi K.

Volltext

Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody dr... von Sapra, Puja Sapra, Tchistiakova, Lioudmila, Dushin, Russell, Leal, Mauricio, DiJoseph, John, Veneziale, Robert, Feyfant, Eric, Gerber, HansPeter, Sun, Ying, Manibusan, Anthony, Lu, Yingchun, Sellers, Aaron, Phuong, Trung, DeGuzman, Michael, Ensari, Semsi, Barnett, Barney, Cho, Ho, Tian, Feng

Volltext

A structural informatics approach to mine kinase knowledge bases von Brooijmans, Natasja, Mobilio, Dominick, Walker, Gary, Nilakantan, Ramaswamy, Denny, Rajiah A., Feyfant, Eric, Diller, David, Bikker, Jack, Humblet, Christine

Volltext

A structural information approach to mine kinase knowledge bases von BROOIJMANS, Natasja, MOBILIO, Dominick, WALKER, Gary, NILAKANTAN, Ramaswamy, DENNY, Rajiah A, FEYFANT, Eric, DILLER, David, BIKKER, Jack, HUMBLET, Christine

Volltext