Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates von RONGZE KUANG, EPP, J. B, SUMEI RUAN, CHONG, L. S, VENKATARAMAN, R, JUAN TU, SHU HE, TRUONG, T. M, GROUTAS, W. C

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1,2,5-Thiadiazolidin-3-one 1,1 Dioxide: A Powerful Scaffold for Probing the S′ Subsites of (Chymo)trypsin-Like Serine Proteases von Groutas, William C., Epp, Jeffrey B., Kuang, Rongze, Ruan, Sumei, Chong, Lee S., Venkataraman, Radhika, Tu, Juan, He, Shu, Yu, Hongyi, Fu, Qinghong, Li, Yue He, Truong, Tien M., Vu, Nga T.

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Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives von Groutas, William C, Houser-Archield, Nadene, Chong, Lee S, Venkataraman, Radhika, Epp, Jeffrey B, Huang, He, McClenahan, Jerald J

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Structure-Based Design of a General Class of Mechanism-Based Inhibitors of the Serine Proteinases Employing a Novel Amino Acid-Derived Heterocyclic Scaffold von Groutas, William C, Kuang, Rongze, Venkataraman, Radhika, Epp, Jeffrey B, Ruan, Sumei, Prakash, Om

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Potent and Specific Inhibition of Human Leukocyte Elastase, Cathepsin G and Proteinase 3 by Sulfone Derivatives Employing the 1,2,5-Thiadiazolidin-3-one 1,1 Dioxide Scaffold von Groutas, William C., Kuang, Rongze, Ruan, Sumei, Epp, Jeffrey B., Venkataraman, Radhika, Truong, Tien M.

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Facile Preparation of Nucleoside-5‘-carboxylic Acids von Epp, Jeffrey B, Widlanski, Theodore S

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Inhibitors of human neutrophil cathepsin G: Structural and biochemical studies von Groutas, William C., Brubaker, Michael J., Venkataraman, Rhadika, Epp, Jeffrey B., Stanga, Michael A., McClenahan, Jerald J.

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Bible history in [the] Hopi Indian language; Old and New Testament von Epp, J. B

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Mechanism-Based Inhibitors of Serine Proteinases Based on the Gabriel-Colman Rearrangement von Groutas, W.C., Chong, L.S., Venkataraman, R., Epp, J.B., Kuang, R.Z., Brubaker, M.J., Houserarchield, N., Huang, H., Mcclenahan, J.J.

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Exploiting Polymerase Promiscuity: A Simple Colorimetric RNA Polymerase Assay von Vassiliou, William, Epp, Jeffery B., Wang, Bin-Bin, Del Vecchio, Alfred M., Widlanski, Theodore, Kao, C.Cheng

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Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners von Groutas, William C., Epp, Jeffrey B., Venkataraman, Radhika, Kuang, Rongze, My Truong, Tien, McClenahan, Jerry J., Prakash, Om

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Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study von Groutas, William C., Venkataraman, Radhika, Chong, Lee S., Yoder, James E., Epp, Jeffrey B., Stanga, Michael A., Kim, Eun-Hong

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Amino Acid-Derived Phthalimide and Saccharin Derivatives as Inhibitors of Human Leukocyte Elastase, Cathepsin G, and Proteinase 3 von Groutas, William C., Chong, Lee S., Venkataraman, Radhika, Kuang, Rongze, Epp, Jeff B., Houser-Archield, Nadene, Huang, He, Hoidal, John R.

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Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3 von Groutas, William C., Brubaker, Michael J., Chong, Lee S., Venkataraman, Radhika, Huang, He, Epp, Jeffrey B., Kuang, Rongze, Hoidal, John R.

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The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors... von Groutas, William C., Chong, Lee S., Venkataraman, Radhika, Epp, Jeffrey B., Kuang, Rongze, Houser-Archield, Nadene, Hoidal, John R.

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A general approach toward the design of mechanism-based inactivators of serine proteinases: inactivation of human leukocyte elastase by a phthalimide derivative von Groutas, William C., Chong, Lee S., Venkataraman, Radhika, Huang, He, Epp, Jeffrey B., Kuang, Rongze

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A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold:  Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based I... von Kuang, Rongze, Epp, Jeffrey B, Ruan, Sumei, Yu, Hongyi, Huang, Peng, He, Shu, Tu, Juan, Schechter, Norman M, Turbov, Jane, Froelich, Christopher J, Groutas, William C

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Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process von Wei, Liuqing, Lai, Zhong, Gan, Xiangdong, Alliston, Kevin R., Zhong, Jiaying, Epp, Jeff B., Tu, Juan, Perera, Asiri B., Stipdonk, Michael Van, Groutas, William C.

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Dual-action inhibitors of proteolytic enzymes: potential therapeutic agents for cystic fibrosis and related ailments von Groutas, William C., Huang, He, Venkataraman, Radhika, Houser-Archield, Nadene, Epp, Jeffrey B.

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A general approach toward the design of inhibitors of serine proteinases: inhibition of human leukocyte elastase by substituted dihydrouracils von Groutas, William C., Huang, He, Epp, Jeffrey B., Brubaker, Michael J., Keller, Charles E., McClenahan, Jerald J.

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