Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition von Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S... von Soares, Pedro, Gadd, Morgan S, Frost, Julianty, Galdeano, Carles, Ellis, Lucy, Epemolu, Ola, Rocha, Sonia, Read, Kevin D, Ciulli, Alessio

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A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on t... von Brandon, Andrew M, Antonides, Lysbeth H, Riley, Jennifer, Epemolu, Ola, McKeown, Denise A, Read, Kevin D, McKenzie, Craig

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Anti-Inflammatory Effects of Auranamide and Patriscabratine—Mechanisms and In Silico Studies von Mak, Kit-Kay, Zhang, Shiming, Low, Jun Sheng, Balijepalli, Madhu Katyayani, Sakirolla, Raghavendra, Dinkova-Kostova, Albena T, Epemolu, Ola, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao

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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs von Green, Simon R., Davis, Susan H., Damerow, Sebastian, Engelhart, Curtis A., Mathieson, Michael, Baragaña, Beatriz, Robinson, David A., Tamjar, Jevgenia, Dawson, Alice, Tamaki, Fabio K., Buchanan, Kirsteen I., Post, John, Dowers, Karen, Shepherd, Sharon M., Jansen, Chimed, Zuccotto, Fabio, Gilbert, Ian H., Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Osuna-Cabello, Maria, Pérez-Herrán, Esther, Rebollo, María José, Guijarro López, Laura, Casado Castro, Patricia, Camino, Isabel, Kim, Heather C., Bean, James M., Nahiyaan, Navid, Rhee, Kyu Y., Wang, Qinglan, Tan, Vee Y., Boshoff, Helena I. M., Converse, Paul J., Li, Si-Yang, Chang, Yong S., Fotouhi, Nader, Upton, Anna M., Nuermberger, Eric L., Schnappinger, Dirk, Read, Kevin D., Encinas, Lourdes, Bates, Robert H., Wyatt, Paul G., Cleghorn, Laura A. T.

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Studies on the mechanism of anti-inflammatory action of swietenine, a tetranortriterpenoid isolated from Swietenia macrophylla seeds von Mak, Kit-Kay, Shiming, Zhang, Balijepalli, Madhu Katyayani, Dinkova-Kostova, Albena T., Epemolu, Ola, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao

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Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability von Mak, Kit-Kay, Shiming, Zhang, Sakirolla, Raghavendra, Balijepalli, Madhu Katyayani, Dinkova-Kostova, Albena T, Epemolu, Ola, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao

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Swietenine Alleviates Nonalcoholic Fatty Liver Disease in Diabetic Mice via Lipogenesis Inhibition and Antioxidant Mechanisms von Mak, Kit-Kay, Zhang, Shiming, Chellian, Jestin, Mohd, Zulkefeli, Epemolu, Ola, Dinkova-Kostova, Albena T, Balijepalli, Madhu Katyayani, Pichika, Mallikarjuna Rao

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Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators von Mak, Kit‐Kay, Shiming, Zhang, Epemolu, Ola, Dinkova‐Kostova, Albena T., Wells, Geoffrey, Gazaryan, Irina G., Sakirolla, Raghavendra, Mohd, Zulkefeli, Pichika, Mallikarjuna Rao

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Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confir... von McKenzie, Craig, Sutcliffe, Oliver B., Read, Kevin D., Scullion, Paul, Epemolu, Ola, Fletcher, Daniel, Helander, Anders, Beck, Olof, Rylski, Alexia, Antonides, Lysbeth H., Riley, Jennifer, Smith, Shannah A., Nic Daeid, Niamh

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The role of DMPK science in improving pharmaceutical research and development efficiency von Mak, Kit-Kay, Epemolu, Ola, Pichika, Mallikarjuna Rao

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The First Potent and Selective Inhibitors of the Glycine Transporter Type 2 von Caulfield, Wilson L, Collie, Iain T, Dickins, Rachel S, Epemolu, Ola, McGuire, Ross, Hill, David R, McVey, Gillian, Morphy, J. Richard, Rankovic, Zoran, Sundaram, Hardy

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Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 von Aggarwal, Anup, Parai, Maloy K., Shetty, Nishant, Wallis, Deeann, Woolhiser, Lisa, Hastings, Courtney, Dutta, Noton K., Galaviz, Stacy, Dhakal, Ramesh C., Shrestha, Rupesh, Wakabayashi, Shoko, Walpole, Chris, Matthews, David, Floyd, David, Scullion, Paul, Riley, Jennifer, Epemolu, Ola, Norval, Suzanne, Snavely, Thomas, Robertson, Gregory T., Rubin, Eric J., Ioerger, Thomas R., Sirgel, Frik A., van der Merwe, Ruben, van Helden, Paul D., Keller, Peter, Böttger, Erik C., Karakousis, Petros C., Lenaerts, Anne J., Sacchettini, James C.

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Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity von Green, Simon R, Wilson, Caroline, Eadsforth, Thomas C, Punekar, Avinash S, Tamaki, Fabio K, Wood, Gavin, Caldwell, Nicola, Forte, Barbara, Norcross, Neil R, Kiczun, Michael, Post, John M, Lopez-Román, Eva Maria, Engelhart, Curtis A, Lukac, Iva, Zuccotto, Fabio, Epemolu, Ola, Boshoff, Helena I M, Schnappinger, Dirk, Walpole, Chris, Gilbert, Ian H, Read, Kevin D, Wyatt, Paul G, Baragaña, Beatriz

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Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB von Cleghorn, Laura A. T, Ray, Peter C, Odingo, Joshua, Kumar, Anuradha, Wescott, Heather, Korkegian, Aaron, Masquelin, Thierry, Lopez Moure, Abraham, Wilson, Caroline, Davis, Susan, Huggett, Margaret, Turner, Penelope, Smith, Alasdair, Epemolu, Ola, Zuccotto, Fabio, Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Ferguson, Liam, Rullas, Joaquin, Guijarro, Laura, Read, Kevin D, Green, Simon R, Hipskind, Phil, Parish, Tanya, Wyatt, Paul G

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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target von Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K, Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Lopez-Román, Eva Maria, Torres-Gómez, Pedro Alfonso, Toledo, Ana Maria, Guijarro-Lopez, Laura, Camino, Isabel, Engelhart, Curtis A, Schnappinger, Dirk, Massoudi, Lisa M, Lenaerts, Anne, Robertson, Gregory T, Walpole, Chris, Matthews, David, Floyd, David, Sacchettini, James C, Read, Kevin D, Encinas, Lourdes, Bates, Robert H, Green, Simon R, Wyatt, Paul G

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Reversal of neuromuscular blockade and simultaneous increase in plasma Rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969 von EPEMOLU, Ola, BOM, Anton, HOPE, Frank, MASON, Rona

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Discovery and Optimization of 5‑Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi von Brand, Stephen, Ko, Eun Jung, Viayna, Elisabet, Thompson, Stephen, Spinks, Daniel, Thomas, Michael, Sandberg, Lars, Francisco, Amanda F, Jayawardhana, Shiromani, Smith, Victoria C, Jansen, Chimed, De Rycker, Manu, Thomas, John, MacLean, Lorna, Osuna-Cabello, Maria, Riley, Jennifer, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C, Epemolu, Ola, Shishikura, Yoko, Crouch, Sabrinia D, Bakshi, Tania S, Nixon, Christopher J, Reid, Iain H, Hill, Alan P, Underwood, Tim Z, Hindley, Sean J, Robinson, Sharon A, Kelly, John M, Fiandor, Jose M, Wyatt, Paul G, Marco, Maria, Miles, Timothy J, Read, Kevin D, Gilbert, Ian H

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Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1 von Bell, Mark, Foley, David, Naylor, Claire, Robinson, Colin, Riley, Jennifer, Epemolu, Ola, Scullion, Paul, Shishikura, Yoko, Katz, Elad, McLean, W.H. Irwin, Wyatt, Paul, Read, Kevin D., Woodland, Andrew

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Reversal of Neuromusclar Blockade and Simultaneous Increase in Plasma Rocuronium Concentration after the Intravenous Infusion of the Novel Reversal Agent Org 25970 von Epemolu, Ola, Bom, Anton, Hope, Frank, Mason, Rona

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