Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor von Kasichayanula, Sreeneeranj, Grover, Anita, Emery, Maurice G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Gibbs, John P.

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Pharmacokinetics of bempedoic acid in patients with renal impairment von Amore, Benny M., Sasiela, William J., Ries, Daniel K., Tresh, Perry, Emery, Maurice G.

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Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation von Amore, Benny M, Patel, Nikunjkumar, Batheja, Priya, Templeton, Ian E, Jones, Hannah M, Louie, Michael J, Emery, Maurice G

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Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers von Amore, Benny M., Cramer, Clay T., MacDougall, Diane E., Sasiela, William J., Emery, Maurice G.

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The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects von Amore, Benny M, Cramer, Clay, MacDougall, Diane, Emery, Maurice G

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Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers... von DIAS, Clapton S, SHAYWITZ, Adam J, GIBBS, John P, RETTER, Marc W, COOKE, Blaire P, UY, Stephen T, MATSON, Mark, STEIN, Evan A, WASSERMAN, Scott M, SMITH, Brian P, BING GAO, STOLMAN, Dina S, CRISPINO, Caroline P, SMIRNAKIS, Karen V, EMERY, Maurice G, COLBERT, Alexander

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Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia von Jadhav, Satyawan B., Amore, Benny M., Bockbrader, Howard, Crass, Ryan L., Chapel, Sunny, Sasiela, William J., Emery, Maurice G.

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Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels von Dias, Clapton S., PhD, Shaywitz, Adam J., MD, PhD, Wasserman, Scott M., MD, Smith, Brian P., PhD, Gao, Bing, PhD, Stolman, Dina S., MD, MSPH, Crispino, Caroline P., MS, Smirnakis, Karen V., MD, MPH, PhD, Emery, Maurice G., PhD, Colbert, Alexander, BA, Gibbs, John P., PhD, Retter, Marc W., PhD, Cooke, Blaire P., PharmD, Uy, Stephen T., MS, Matson, Mark, MD, Stein, Evan A., MD, PhD

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Impact of Target‐Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) von Gibbs, John P., Doshi, Sameer, Kuchimanchi, Mita, Grover, Anita, Emery, Maurice G., Dodds, Michael G., Gibbs, Megan A., Somaratne, Ransi, Wasserman, Scott M., Blom, Dirk

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Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective In... von Amore, Benny M, MacDougall, Diane E, Hanselman, Jeffrey C, Emery, Maurice G

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Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model von Jadhav, Satyawan B, Crass, Ryan L, Chapel, Sunny, Kerschnitzki, Michael, Sasiela, William J, Emery, Maurice G, Amore, Benny M, Barrett, P Hugh R, Watts, Gerald F, Catapano, Alberico L

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Evaluation of Evolocumab (AMG 145), a Fully Human Anti‐PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment von Gibbs, John P., Slatter, J. Greg, Egbuna, Ogo, Geller, Michelle, Hamilton, Lisa, Dias, Clapton S., Xu, Ren Y., Johnson, Jessica, Wasserman, Scott M., Emery, Maurice G.

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Population pharmacokinetics and exposure–response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia von Kuchimanchi, Mita, Grover, Anita, Emery, Maurice G., Somaratne, Ransi, Wasserman, Scott M., Gibbs, John P., Doshi, Sameer

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Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-iso... von Véniant, Murielle M, Hale, Clarence, Hungate, Randall W, Gahm, Kyung, Emery, Maurice G, Jona, Janan, Joseph, Smriti, Adams, Jeffrey, Hague, Andrew, Moniz, George, Zhang, Jiandong, Bartberger, Michael D, Li, Vivian, Syed, Rashid, Jordan, Steven, Komorowski, Renée, Chen, Michelle M, Cupples, Rod, Kim, Ki Won, St. Jean, David J, Johansson, Lars, Henriksson, Martin A, Williams, Meredith, Vallgårda, Jerk, Fotsch, Christopher, Wang, Minghan

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CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease von Emery, Maurice G., Fisher, Jeannine M., Chien, Jenny Y., Kharasch, Evan D., Dellinger, E.Patchen, Kowdley, Kris V., Thummel, Kenneth E.

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Comparison of LDL-C Reduction Using Different Evolocumab Doses and Intervals: Biological Insights and Treatment Implications von Wasserman, Scott M., Sabatine, Marc S., Koren, Michael J., Giugliano, Robert P., Legg, Jason C., Emery, Maurice G., Doshi, Sameer, Liu, Thomas, Somaratne, Ransi, Gibbs, John P.

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Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety von Lee, Edward, Gibbs, John P., Emery, Maurice G., Block, Geoffrey, Wasserman, Scott M., Hamilton, Lisa, Kasichayanula, Sreeneeranj, Hanafin, Patrick, Somaratne, Ransi, Egbuna, Ogo

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SRM-based measurements of proprotein convertase subtilisin/kexin type 9 and lipoprotein(a) kinetics in nonhuman primate serum von Xie, Fang, Emery, Maurice G, Gibbs, John P, Rock, Dan A, Rock, Brooke M

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Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Activity After Oral Administration of AMG 221, a Selecti... von Gibbs, John P., Emery, Maurice G., McCaffery, Ian, Smith, Brian, Gibbs, Megan A., Akrami, Anna, Rossi, John, Paweletz, Katherine, Gastonguay, Marc R., Bautista, Edgar, Wang, Minghan, Perfetti, Riccardo, Daniels, Oranee

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Regiospecific and stereospecific triangulation of the structures of metabolites formed by sequential metabolism at multiple prochiral centers von Greene, Robert J, Davis, John A, Subramanian, Raju, Deane, Molly R, Emery, Maurice G, Slatter, J Greg

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