Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation von Feige, Jérôme N., Lagouge, Marie, Canto, Carles, Strehle, Axelle, Houten, Sander M., Milne, Jill C., Lambert, Philip D., Mataki, Chikage, Elliott, Peter J., Auwerx, Johan

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes von Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei

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Systematic Discovery of Multicomponent Therapeutics von Borisy, Alexis A., Elliott, Peter J., Hurst, Nicole W., Lee, Margaret S., Lehár, Joseph, Price, E. Roydon, Serbedzija, George, Zimmermann, Grant R., Foley, Michael A., Stockwell, Brent R., Keith, Curtis T.

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Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells von BREITENSTEIN, Alexander, STEIN, Sokrates, LÜSCHER, Thomas F, TANNER, Felix C, HOLY, Erik W, CAMICI, Giovanni G, LOHMANN, Christine, AKHMEDOV, Alexander, SPESCHA, Remo, ELLIOTT, Peter J, WESTPHAL, Christoph H, MATTER, Christian M

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Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo von Smith, Jesse J, Kenney, Renée Deehan, Gagne, David J, Frushour, Brian P, Ladd, William, Galonek, Heidi L, Israelian, Kristine, Song, Jeffrey, Razvadauskaite, Giedre, Lynch, Amy V, Carney, David P, Johnson, Robin J, Lavu, Siva, Iffland, Andre, Elliott, Peter J, Lambert, Philip D, Elliston, Keith O, Jirousek, Michael R, Milne, Jill C, Boss, Olivier

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A Phase I Trial of the Novel Proteasome Inhibitor PS341 in Advanced Solid Tumor Malignancies von AGHAJANIAN, Carol, SOIGNET, Steven, CANALES, Christina, DAUD, Adil, SPRIGGS, David R, DIZON, Don S, PIEN, Christine S, ADAMS, Julian, ELLIOTT, Peter J, SABBATINI, Paul, MILLER, Vincent, HENSLEY, Martee L, PEZZULLI, Sandra

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Proteasome inhibition: a new anti-inflammatory strategy von ELLIOTT, Peter J, ZOLLNER, Thomas Matthias, BOEHNCKE, Wolf-Henning

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The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP von Sayers, Thomas J., Brooks, Alan D., Koh, Crystal Y., Ma, Weihong, Seki, Naoko, Raziuddin, Arati, Blazar, Bruce R., Zhang, Xia, Elliott, Peter J., Murphy, William J.

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AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity von Lagouge, Marie, Gerhart-Hines, Zachary, Elliott, Peter J, Auwerx, Johan, Feige, Jerome N, Noriega, Lilia, Puigserver, Pere, Milne, Jill C, Cantó, Carles

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Proteasome Inhibition Measurements: Clinical Application von Lightcap, Eric S, McCormack, Teresa A, Pien, Christine S, Chau, Vincent, Adams, Julian, Elliott, Peter J

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Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia von Phillips, J B, Williams, A J, Adams, J, Elliott, P J, Tortella, F C

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Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span von Pearson, Kevin J., Baur, Joseph A., Lewis, Kaitlyn N., Peshkin, Leonid, Price, Nathan L., Labinskyy, Nazar, Swindell, William R., Kamara, Davida, Minor, Robin K., Perez, Evelyn, Jamieson, Hamish A., Zhang, Yongqing, Dunn, Stephen R., Sharma, Kumar, Pleshko, Nancy, Woollett, Laura A., Csiszar, Anna, Ikeno, Yuji, Le Couteur, David, Elliott, Peter J., Becker, Kevin G., Navas, Placido, Ingram, Donald K., Wolf, Norman S., Ungvari, Zoltan, Sinclair, David A., de Cabo, Rafael

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SRT1720 improves survival and healthspan of obese mice von Minor, Robin K., Baur, Joseph A., Gomes, Ana P., Ward, Theresa M., Csiszar, Anna, Mercken, Evi M., Abdelmohsen, Kotb, Shin, Yu-Kyong, Canto, Carles, Scheibye-Knudsen, Morten, Krawczyk, Melissa, Irusta, Pablo M., Martín-Montalvo, Alejandro, Hubbard, Basil P., Zhang, Yongqing, Lehrmann, Elin, White, Alexa A., Price, Nathan L., Swindell, William R., Pearson, Kevin J., Becker, Kevin G., Bohr, Vilhelm A., Gorospe, Myriam, Egan, Josephine M., Talan, Mark I., Auwerx, Johan, Westphal, Christoph H., Ellis, James L., Ungvari, Zoltan, Vlasuk, George P., Elliott, Peter J., Sinclair, David A., de Cabo, Rafael

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells von HIDESHIMA, Teru, RICHARDSON, Paul, CHAUHAN, Dharminder, PALOMBELLA, Vito J, ELLIOTT, Peter J, ADAMS, Julian, ANDERSON, Kenneth C

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The Proteasome Inhibitor Bortezomib (Velcade) Sensitizes Some Human Tumor Cells to Apo2L/TRAIL-Mediated Apoptosis von BROOKS, ALAN D., RAMIREZ, TERESA, TOH, UHI, ONKSEN, JENNIFER, ELLIOTT, PETER J., MURPHY, WILLIAM J., SAYERS, THOMAS J.

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Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341 : Implications for systemic nuclear factor-κB inhibition von CUSACK, James C, RONG LIU, HOUSTON, Michael, ABENDROTH, Karin, ELLIOTT, Peter J, ADAMS, Julian, BALDWIN, Albert S

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Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model von Zollner, Thomas M, Podda, Maurizio, Pien, Christine, Elliott, Peter J, Kaufmann, Roland, Boehncke, Wolf-Henning

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Role of the Proteasome and NF-κ B in Streptococcal Cell Wall-Induced Polyarthritis von Palombella, Vito J., Conner, Elaine M., Fuseler, John W., Destree, Antonia, Davis, Jonathan M., Laroux, F. Stephen, Wolf, Robert E., Huang, Jianqing, Brand, Stephen, Elliott, Peter J., Lazarus, Douglas, McCormack, Teresa, Parent, Lana, Stein, Ross, Adams, Julian, Grisham, Matthew B.

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Postischemic (6-hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral isch... von LI ZHANG, ZHENG GANG ZHANG, RUI LAN ZHANG, MEI LU, ADAMS, Julian, ELLIOTT, Peter J, CHOPP, Michael

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Proteasome inhibition: A novel mechanism to combat asthma von Elliott, Peter J., Pien, Christine S., McCormack, Teresa A., Chapman, Ian D., Adams, Julian

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