Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia von Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.

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Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines von Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J

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Reducing the Lipophilicity of Perfluoroalkyl Groups by CF2–F/CF2–Me or CF3/CH3 Exchange von Jeffries, Benjamin, Wang, Zhong, Graton, Jérôme, Holland, Simon D, Brind, Thomasin, Greenwood, Ryan D. R, Le Questel, Jean-Yves, Scott, James S, Chiarparin, Elisabetta, Linclau, Bruno

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Observing an Antisense Drug Complex in Intact Human Cells by in‐Cell NMR Spectroscopy von Schlagnitweit, Judith, Friebe Sandoz, Sarah, Jaworski, Aleksander, Guzzetti, Ileana, Aussenac, Fabien, Carbajo, Rodrigo J., Chiarparin, Elisabetta, Pell, Andrew J., Petzold, Katja

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A protein tertiary structure mimetic modulator of the Hippo signalling pathway von Adihou, Hélène, Gopalakrishnan, Ranganath, Förster, Tim, Guéret, Stéphanie M., Gasper, Raphael, Geschwindner, Stefan, Carrillo García, Carmen, Karatas, Hacer, Pobbati, Ajaybabu V., Vazquez‐Chantada, Mercedes, Davey, Paul, Wassvik, Carola M., Pang, Jeremy Kah Sheng, Soh, Boon Seng, Hong, Wanjin, Chiarparin, Elisabetta, Schade, Dennis, Plowright, Alleyn T., Valeur, Eric, Lemurell, Malin, Grossmann, Tom N., Waldmann, Herbert

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Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl‑1 Inhibitor (AZD5991) and Other Synthetic Macrocycles von Balazs, Amber Y. S, Carbajo, Rodrigo J, Davies, Nichola L, Dong, Yu, Hird, Alexander W, Johannes, Jeffrey W, Lamb, Michelle L, McCoull, William, Raubo, Piotr, Robb, Graeme R, Packer, Martin J, Chiarparin, Elisabetta

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Experimental free ligand conformations: a missing link in structure-based drug discovery von Chiarparin, Elisabetta, Packer, Martin J, Wilson, David M

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Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives von Tisi, Dominic, Chiarparin, Elisabetta, Tamanini, Emiliano, Pathuri, Puja, Coyle, Joseph E, Hold, Adam, Holding, Finn P, Amin, Nader, Martin, Agnes C. L, Rich, Sharna J, Berdini, Valerio, Yon, Jeff, Acklam, Paul, Burke, Rosemary, Drouin, Ludovic, Harmer, Jenny E, Jeganathan, Fiona, van Montfort, Rob L. M, Newbatt, Yvette, Tortorici, Marcello, Westlake, Maura, Wood, Amy, Hoelder, Swen, Heightman, Tom D

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Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups von Jeffries, Benjamin, Wang, Zhong, Troup, Robert I, Goupille, Anaïs, Le Questel, Jean-Yves, Fallan, Charlene, Scott, James S, Chiarparin, Elisabetta, Graton, Jérôme, Linclau, Bruno

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Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling von Kapustin, Alexander N., Davey, Paul, Longmire, David, Matthews, Carl, Linnane, Emily, Rustogi, Nitin, Stavrou, Maria, Devine, Paul W. A., Bond, Nicholas J., Hanson, Lyndsey, Sonzini, Silvia, Revenko, Alexey, MacLeod, A. Robert, Ross, Sarah, Chiarparin, Elisabetta, Puri, Sanyogitta

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Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC von Hayhow, Thomas G., Williamson, Beth, Lawson, Mandy, Cureton, Natalie, Braybrooke, Erin L., Campbell, Andrew, Carbajo, Rodrigo J., Cheraghchi-Bashi, Azadeh, Chiarparin, Elisabetta, Diène, Coura R., Fallan, Charlene, Fisher, David I., Goldberg, Frederick W., Hopcroft, Lorna, Hopcroft, Philip, Jackson, Anne, Kettle, Jason G., Klinowska, Teresa, Künzel, Ulrike, Lamont, Gillian, Lewis, Hilary J., Maglennon, Gareth, Martin, Scott, Gutierrez, Pablo Morentin, Morrow, Christopher J., Nikolaou, Myria, Nissink, J. Willem M., O’Shea, Patrick, Polanski, Radoslaw, Schade, Markus, Scott, James S., Smith, Aaron, Weber, Judith, Wilson, Joanne, Yang, Bin, Crafter, Claire

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Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders von Di Fabio, Romano, Pellacani, Annalisa, Faedo, Stefania, Roth, Adelheid, Piccoli, Laura, Gerrard, Philip, Porter, Rod A., Johnson, Christopher N., Thewlis, Kevin, Donati, Daniele, Stasi, Luigi, Spada, Simone, Stemp, Geoffrey, Nash, David, Branch, Clive, Kindon, Leanda, Massagrande, Mario, Poffe, Alessandro, Braggio, Simone, Chiarparin, Elisabetta, Marchioro, Carla, Ratti, Emiliangelo, Corsi, Mauro

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Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States: Improved Contrast in Fragment-Based Drug Screening von Buratto, Roberto, Mammoli, Daniele, Chiarparin, Elisabetta, Williams, Glyn, Bodenhausen, Geoffrey

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Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs von Jeffries, Benjamin, Wang, Zhong, Felstead, Hannah R, Le Questel, Jean-Yves, Scott, James S, Chiarparin, Elisabetta, Graton, Jérôme, Linclau, Bruno

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex von Hsu, Jessie Hao-Ru, Rasmusson, Timothy, Robinson, James, Pachl, Fiona, Read, Jon, Kawatkar, Sameer, O’ Donovan, Daniel H., Bagal, Sharan, Code, Erin, Rawlins, Philip, Argyrou, Argyrides, Tomlinson, Ronald, Gao, Ning, Zhu, Xiahui, Chiarparin, Elisabetta, Jacques, Kelly, Shen, Minhui, Woods, Haley, Bednarski, Emma, Wilson, David M., Drew, Lisa, Castaldi, M. Paola, Fawell, Stephen, Bloecher, Andrew

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In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR von Bertarello, Andrea, Berruyer, Pierrick, Artelsmair, Markus, Elmore, Charles S, Heydarkhan-Hagvall, Sepideh, Schade, Markus, Chiarparin, Elisabetta, Schantz, Staffan, Emsley, Lyndon

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Design, Synthesis, and Analytical Evaluation of Fsp 3 ‐Inspired Raman Probes for Cellular Imaging von Steven, Craig F., Lee, Martin, Nichol, Gary S., Davey, Paul R. J., Chiarparin, Elisabetta, Brunton, Valerie G., Hulme, Alison N.

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Conformationally Controlled sp3‐Hydrocarbon‐Based α‐Helix Mimetics von Dewis, Lydia I., Rudrakshula, Madhavachary, Williams, Christopher, Chiarparin, Elisabetta, Myers, Eddie L., Butts, Craig P., Aggarwal, Varinder K.

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Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling von Wendt, Mathias, Bellavita, Rosa, Gerber, Alan, Efrém, Nina‐Louisa, Ramshorst, Thirza, Pearce, Nicholas M., Davey, Paul R. J., Everard, Isabel, Vazquez‐Chantada, Mercedes, Chiarparin, Elisabetta, Grieco, Paolo, Hennig, Sven, Grossmann, Tom N.

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In Vitro Measurement of Drug Efficiency Index to Aid Early Lead Optimization von Valko, Klara, Chiarparin, Elisabetta, Nunhuck, Shenaz, Montanari, Dino

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