A phase Ib study of the highly selective MET-TKI savolitinib plus gefitinib in patients with EGFR-mutated, MET-amplified advanced non-small-cell lung cancer von Yang, Jin-Ji, Fang, Jian, Shu, Yong-Qian, Chang, Jian-Hua, Chen, Gong-Yan, He, Jian Xing, Li, Wei, Liu, Xiao-Qing, Yang, Nong, Zhou, Caicun, Huang, Jian An, Frigault, Melanie M., Hartmaier, Ryan, Ahmed, Ghada F., Egile, Coumaran, Morgan, Shethah, Verheijen, Remy B., Mellemgaard, Anders, Yang, Liu, Wu, Yi-Long

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The Structural Basis of Actin Filament Branching by the Arp2/3 Complex von Rouiller, Isabelle, Xu, Xiao-Ping, Amann, Kurt J., Egile, Coumaran, Nickell, Stephan, Nicastro, Daniela, Li, Rong, Pollard, Thomas D., Volkmann, Niels, Hanein, Dorit

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The RickA protein of Rickettsia conorii activates the Arp2/3 complex von Cossart, Pascale, Gouin, Edith, Egile, Coumaran, Dehoux, Pierre, Villiers, Véronique, Adams, Josephine, Gertler, Frank, Li, Rong

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Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib von Barnicle, Alan, Ray-Coquard, Isabelle, Rouleau, Etienne, Cadoo, Karen, Simpkins, Fiona, Aghajanian, Carol, Leary, Alexandra, Poveda, Andrés, Lheureux, Stephanie, Pujade-Lauraine, Eric, You, Benoit, Ledermann, Jonathan, Matulonis, Ursula, Gourley, Charlie, Timms, Kirsten M, Lai, Zhongwu, Hodgson, Darren R, Elks, Cathy E, Dearden, Simon, Egile, Coumaran, Lao-Sirieix, Pierre, Harrington, Elizabeth A, Brown, Jessica S

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Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1‑{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3‑b]pyridazin-3-ylsulfanyl]... von Ugolini, Antonio, Kenigsberg, Mireille, Rak, Alexey, Vallée, Francois, Houtmann, Jacques, Lowinski, Maryse, Capdevila, Cécile, Khider, Jean, Albert, Eva, Martinet, Nathalie, Nemecek, Conception, Grapinet, Sandrine, Bacqué, Eric, Roesner, Manfred, Delaisi, Christine, Calvet, Loreley, Bonche, Fabrice, Semiond, Dorothée, Egile, Coumaran, Goulaouic, Hélène, Schio, Laurent

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Activation of Arp2/3 complex-mediated actin polymerization by cortactin von Zhan, Xi, Uruno, Takehito, Liu, Jiali, Zhang, Peijun, Fan, Ying-xin, Egile, Coumaran, Li, Rong, Mueller, Susette C

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IQGAP1 Stimulates Actin Assembly through the N-Wasp-Arp2/3 Pathway von Le Clainche, Christophe, Schlaepfer, Dominik, Ferrari, Aldo, Klingauf, Mirko, Grohmanova, Katarina, Veligodskiy, Alexey, Didry, Dominique, Le, Diep, Egile, Coumaran, Carlier, Marie-France, Kroschewski, Ruth

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Activation of the CDC42 Effector N-WASP by the Shigella flexneri IcsA Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility von Egile, Coumaran, Loisel, Thomas P., Laurent, Valérie, Li, Rong, Pantaloni, Dominique, Sansonetti, Philippe J., Carlier, Marie-France

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MET genetic abnormalities unreliable for patient selection for therapeutic intervention in oropharyngeal squamous cell carcinoma von Lacroix, Ludovic, Post, Sophie F, Valent, Alexander, Melkane, Antoine E, Vielh, Philippe, Egile, Coumaran, Castell, Christelle, Larois, Christelle, Micallef, Sandrine, Saulnier, Patrick, Goulaouic, Hélène, Lefebvre, Anne-Marie, Temam, Stéphane

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Cortactin regulates cell migration through activation of N-WASP von Kowalski, Jennifer R, Egile, Coumaran, Gil, Susana, Snapper, Scott B, Li, Rong, Thomas, Sheila M

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Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions von Egile, Coumaran, Rouiller, Isabelle, Xu, Xiao-Ping, Volkmann, Niels, Li, Rong, Hanein, Dorit

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Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions von Volkmann, Niels, Amann, Kurt J., Stoilova-McPhie, Svetla, Egile, Coumaran, Winter, Dirk C., Hazelwood, Larnele, Heuser, John E., Li, Rong, Pollard, Thomas D., Hanein, Dorit

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Characterization of TccP‐mediated N‐WASP activation during enterohaemorrhagic Escherichia coli infection von Garmendia, Junkal, Carlier, Marie‐France, Egile, Coumaran, Didry, Dominique, Frankel, Gad

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GRB2 Links Signaling to Actin Assembly by Enhancing Interaction of Neural Wiskott-Aldrich Syndrome Protein (N-WASp) with Actin-related Protein (ARP2/3) Complex von Carlier, Marie-France, Nioche, Pierre, Broutin-L'Hermite, Isabelle, Boujemaa, Rajaa, Le Clainche, Christophe, Egile, Coumaran, Garbay, Christiane, Ducruix, Arnaud, Sansonetti, Philippe, Pantaloni, Dominique

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ARPC1/Arc40 Mediates the Interaction of the Actin-related Protein 2 and 3 Complex with Wiskott-Aldrich Syndrome Protein Family Activators von Pan, Feng, Egile, Coumaran, Lipkin, Thomas, Li, Rong

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Activation of Arp2/3 Complex-Dependent Actin Polymerization by Plant Proteins Distantly Related to Scar/WAVE von Frank, Mary, Egile, Coumaran, Dyachok, Julia, Djakovic, Stevan, Nolasco, Michelle, Li, Rong, Smith, Laurie G., Chrispeels, Maarten J.

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Interaction of N-WASP with hnRNPK and Its Role in Filopodia Formation and Cell Spreading von Yoo, Youngdong, Wu, Xiaoyang, Egile, Coumaran, Li, Rong, Guan, Jun-Lin

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Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinoma von Matulonis, Ursula, Vergote, Ignace, Backes, Floor, Martin, Lainie P, McMeekin, Scott, Birrer, Michael, Campana, Frank, Xu, Yi, Egile, Coumaran, Ghamande, Sharad

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SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri von Egile, Coumaran, D’Hauteville, Hélène, Parsot, Claude, Sansonetti, Philippe J.

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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245408 (XL147), an Oral Pan-Class I PI3K Inhibitor, in Patients with Advanced Solid Tumors von SHAPIRO, Geoffrey I, RODON, Jordi, YI XU, EGILE, Coumaran, EDELMAN, Gerald, BEDELL, Cynthia, KWAK, Eunice L, BASELGA, Jose, BRANA, Irene, PANDYA, Shuchi S, SCHEFFOLD, Christian, LAIRD, A. Douglas, NGUYEN, Linh T

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