Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia von Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.

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Expression of Epiregulin and Amphiregulin and K-ras Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab von KHAMBATA-FORD, Shirin, GARRETT, Christopher R, TAN, Benjamin R, KRISHNAMURTHI, Smitha S, BURRIS, Howard A, POPLIN, Elizabeth A, HIDALGO, Manuel, BASELGA, Jose, CLARK, Edwin A, MAURO, David J, MEROPOL, Neal, BASIK, Mark, HARBISON, Christopher T, SHUJIAN WU, WONG, Tai W, XIN HUANG, TAKIMOTO, Chris H, GODWIN, Andrew K

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The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models von Schuller, Alwin G, Barry, Evan R, Jones, Rhys D O, Henry, Ryan E, Frigault, Melanie M, Beran, Garry, Linsenmayer, David, Hattersley, Maureen, Smith, Aaron, Wilson, Joanne, Cairo, Stefano, Déas, Olivier, Nicolle, Delphine, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Fawell, Stephen E, Clark, Edwin A, D'Cruz, Celina M

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Genomic analysis of metastasis reveals an essential role for RhoC von Clark, Edwin A., Golub, Todd R., Lander, Eric S., Hynes, Richard O.

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Integrins and Signal Transduction Pathways: The Road Taken von Clark, Edwin A., Brugge, Joan S.

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Biomarker-Based Phase II Trial of Savolitinib in Patients With Advanced Papillary Renal Cell Cancer von Choueiri, Toni K, Plimack, Elizabeth, Arkenau, Hendrik-Tobias, Jonasch, Eric, Heng, Daniel Y C, Powles, Thomas, Frigault, Melanie M, Clark, Edwin A, Handzel, Amir A, Gardner, Humphrey, Morgan, Shethah, Albiges, Laurence, Pal, Sumanta Kumar

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Integrin-Mediated Signals Regulated by Members of the Rho Family of GTPases von Clark, Edwin A., King, Warren G., Brugge, Joan S., Symons, Marc, Hynes, Richard O.

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Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib von Serrels, Alan, Macpherson, Iain R J, Evans, T R Jeffry, Lee, Francis Y, Clark, Edwin A, Sansom, Owen J, Ashton, Gabrielle H, Frame, Margaret C, Brunton, Valerie G

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Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy von HARTMANN, Lynn C, LU, Karen H, ROSS, Jeffrey S, HOERSCH, Sebastian, SHRIDHAR, Viji, LILLIE, James, KAUFMANN, Scott H, CLARK, Edwin A, DAMOKOSH, Andrew I, LINETTE, Gerald P, CLIBY, William A, KALLI, Kimberly R, GERSHENSON, David, BAST, Robert C, STEC, James, IARTCHOUK, Natalia, SMITH, David I

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Total RNA yield and microarray gene expression profiles from fine‐needle aspiration biopsy and core‐needle biopsy samples of breast carcinoma von Symmans, W. Fraser, Ayers, Mark, Clark, Edwin A., Stec, James, Hess, Kenneth R., Sneige, Nour, Buchholz, Thomas A., Krishnamurthy, Savitri, Ibrahim, Nuhad K., Buzdar, Aman U., Theriault, Richard L., Rosales, Marguerite F.M., Thomas, Eva S., Gwyn, Karin M., Green, Marjorie C., Syed, Abdul R., Hortobagyi, Gabriel N., Pusztai, Lajos

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Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model von EFFERSON, Clay L, WINKELMANN, Christopher T, BUSER, Carolyn, YEATMAN, Timothy, COPPOLA, Domenico, WINTER, Christopher, CLARK, Edwin A, DRAETTA, Giulio F, STRACK, Peter R, MAJUMDER, Pradip K, WARE, Christopher, SULLIVAN, Timothy, GIAMPAOLI, Saverio, TAMMAM, Jennifer, PATEL, Shailendra, MESITI, Giuseppe, REILLY, John F, GIBSON, Raymond E

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Regulation of protein tyrosine kinases in platelets von Clark, Edwin A., Shattil, Sanford J., Brugge, Joan S.

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Abstract 311: AZD4320 is a potent, dual Bcl-2/xLinhibitor that rapidly induces apoptosis in preclinical hematologic tumor models von Cidado, Justin, Secrist, J Paul, Gibbons, Francis D., Hennessy, Edward J., Ioannidis, Stephanos, Clark, Edwin A.

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Abstract 302: Selective Mcl-1 inhibition by AZD5991 induces on-target cell death and achieves antitumor activity in multiple myeloma and acute myeloid leukemia von Tron, Adriana E., Belmonte, Matthew A., Criscione, Steven, Clark, Edwin A., Gangl, Eric, Gibbons, Francis D., Tyner, Jeffrey W., Kurtz, Stephen E., Ye, Qing, Hird, Alexander W., Schuller, Alwin, Secrist, J. Paul

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1997 keystone symposium on signal transduction by cell adhesion receptors von Clark, Edwin A, Hynes, Richard O

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Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers von Hird, Alexander W., Secrist, J. Paul, Adam, Ammar, Belmonte, Matthew A., Gangl, Eric, Gibbons, Frank, Hargreaves, David, Johannes, Jeffrey W., Kazmirski, Stephen L., Kettle, Jason G., Kurtz, Stephen E., Lamb, Michelle L., Packer, Martin J., Peng, Bo, Stewart, Craig R., Tyner, Jeffrey W., Yang, Wenzhan, Ye, Qing, Zheng, XiaoLan, Clark, Edwin A.

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The Differential Role of Protein Kinase C Isozyme in the Rapid Induction of Neurofilament Phosphorylation by Nerve Growth Factor and Phorbol Esters in PC12 Cells von Clark, Edwin A., Lee, Virginia M.‐Y.

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Ras Activation Is Necessary for Integrin-mediated Activation of Extracellular Signal-regulated Kinase 2 and Cytosolic Phospholipase A2 but Not for Cytoskeletal Organization von Clark, E A, Hynes, R O

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In Reply von Harbison, Christopher T., Mauro, David J., Clark, Edwin A., Khambata-Ford, Shirin

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Pharmacogenomics of Dasatinib (Sprycel™) von Huang, Fei, Clark, Edwin A

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