Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate von Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V

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Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability von Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, Hiebert, Scott W.

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EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression von Renneville, Aline, Van Galen, Peter, Canver, Matthew C., McConkey, Marie, Krill-Burger, John M., Dorfman, David M., Holson, Edward B., Bernstein, Bradley E., Orkin, Stuart H., Bauer, Daniel E., Ebert, Benjamin L.

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In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs von Wang, Changning, Schroeder, Frederick A, Wey, Hsiao-Ying, Borra, Ronald, Wagner, Florence F, Reis, Surya, Kim, Sung Won, Holson, Edward B, Haggarty, Stephen J, Hooker, Jacob M

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Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy von Ferguson, Bradley S., Harrison, Brooke C., Jeong, Mark Y., Reid, Brian G., Wempe, Michael F., Wagner, Florence F., Holson, Edward B., McKinsey, Timothy A.

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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests von Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

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Selective HDAC inhibition for the disruption of latent HIV-1 infection von Barton, Kirston M, Archin, Nancie M, Keedy, Kara S, Espeseth, Amy S, Zhang, Yan-ling, Gale, Jennifer, Wagner, Florence F, Holson, Edward B, Margolis, David M

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Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases von Wagner, Florence F., Weїwer, Michel, Lewis, Michael C., Holson, Edward B.

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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries von Lowe, Jason T, Lee, Maurice D, Akella, Lakshmi B, Davoine, Emeline, Donckele, Etienne J, Durak, Landon, Duvall, Jeremy R, Gerard, Baudouin, Holson, Edward B, Joliton, Adrien, Kesavan, Sarathy, Lemercier, Berenice C, Liu, Haibo, Marié, Jean-Charles, Mulrooney, Carol A, Muncipinto, Giovanni, Welzel-O’Shea, Morgan, Panko, Laura M, Rowley, Ann, Suh, Byung-Chul, Thomas, Meryl, Wagner, Florence F, Wei, Jingqiang, Foley, Michael A, Marcaurelle, Lisa A

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HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury von Aufhauser, David D., Hernandez, Paul, Concors, Seth J., O’Brien, Ciaran, Wang, Zhonglin, Murken, Douglas R., Samanta, Arabinda, Beier, Ulf H., Krumeich, Lauren, Bhatti, Tricia R., Wang, Yanfeng, Ge, Guanghui, Wang, Liqing, Cheraghlou, Shayan, Wagner, Florence F., Holson, Edward B., Kalin, Jay H., Cole, Philip A., Hancock, Wayne W., Levine, Matthew H.

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AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice von Pan, Jen Q, Lewis, Michael C, Ketterman, Josh K, Clore, Elizabeth L, Riley, Misha, Richards, Keenan R, Berry-Scott, Erin, Liu, Xiulin, Wagner, Florence F, Holson, Edward B, Neve, Rachael L, Biechele, Travis L, Moon, Randall T, Scolnick, Edward M, Petryshen, Tracey L, Haggarty, Stephen J

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Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition von Sleiman, Sama F, Olson, David E, Bourassa, Megan W, Karuppagounder, Saravanan S, Zhang, Yan-Ling, Gale, Jennifer, Wagner, Florence F, Basso, Manuela, Coppola, Giovanni, Pinto, John T, Holson, Edward B, Ratan, Rajiv R

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Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases von Karnib, Nabil, El-Ghandour, Rim, El Hayek, Lauretta, Nasrallah, Patrick, Khalifeh, Mohamad, Barmo, Nour, Jabre, Vanessa, Ibrahim, Pascale, Bilen, Maria, Stephan, Joseph S, Holson, Edward B, Ratan, Rajiv R, Sleiman, Sama F

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Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells von Kubicek, Stefan, Gilbert, Joshua C, Fomina-Yadlin, Dina, Gitlin, Alexander D, Yuan, Yuan, Wagner, Florence F, Holson, Edward B, Luo, Tuoping, Lewis, Timothy A, Taylor, Bradley, Gupta, Supriya, Shamji, Alykhan F, Wagner, Bridget K, Clemons, Paul A, Schreiber, Stuart L

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Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes von Dirice, Ercument, Ng, Raymond W.S., Martinez, Rachael, Hu, Jiang, Wagner, Florence F., Holson, Edward B., Wagner, Bridget K., Kulkarni, Rohit N.

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Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif von Wagner, Florence F, Olson, David E, Gale, Jennifer P, Kaya, Taner, Weïwer, Michel, Aidoud, Nadia, Thomas, Méryl, Davoine, Emeline L, Lemercier, Bérénice C, Zhang, Yan-Ling, Holson, Edward B

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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging von Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil

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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β‑Cell Protection von Wagner, Florence F, Lundh, Morten, Kaya, Taner, McCarren, Patrick, Zhang, Yan-Ling, Chattopadhyay, Shrikanta, Gale, Jennifer P, Galbo, Thomas, Fisher, Stewart L, Meier, Bennett C, Vetere, Amedeo, Richardson, Sarah, Morgan, Noel G, Christensen, Dan Ploug, Gilbert, Tamara J, Hooker, Jacob M, Leroy, Mélanie, Walpita, Deepika, Mandrup-Poulsen, Thomas, Wagner, Bridget K, Holson, Edward B

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Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors von Olson, David E, Wagner, Florence F, Kaya, Taner, Gale, Jennifer P, Aidoud, Nadia, Davoine, Emeline L, Lazzaro, Fanny, Weïwer, Michel, Zhang, Yan-Ling, Holson, Edward B

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Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors von Wagner, Florence F., Weïwer, Michel, Steinbacher, Stefan, Schomburg, Adrian, Reinemer, Peter, Gale, Jennifer P., Campbell, Arthur J., Fisher, Stewart L., Zhao, Wen-Ning, Reis, Surya A., Hennig, Krista M., Thomas, Méryl, Müller, Peter, Jefson, Martin R., Fass, Daniel M., Haggarty, Stephen J., Zhang, Yan-Ling, Holson, Edward B.

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