The discovery of first-in-class drugs: origins and evolution von Eder, Jörg, Sedrani, Richard, Wiesmann, Christian

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Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition von Dekker, Carien, Mattes, Henri, Wright, Michael, Boettcher, Andreas, Hinniger, Alexandra, Hughes, Nicola, Kapps-Fouthier, Sandra, Eder, Jörg, Erbel, Paulus, Stiefl, Nikolaus, Mackay, Angela, Farady, Christopher J.

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Targeted inhibition of the COP9 signalosome for treatment of cancer von Schlierf, Anita, Altmann, Eva, Quancard, Jean, Jefferson, Anne B., Assenberg, René, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Schaefer, Michael, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Jörg, Martoglio, Bruno

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MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans von Koch, Alexander W., Schiering, Nikolaus, Melkko, Samu, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, McCormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, Côté, Serge, DeGagne, Julie, Krantz, Carsten, Eder, Jörg, Stoll, Brian, Kulmatycki, Kenneth, Feldman, David L., Hoffmann, Peter, Basson, Craig T., Frost, Robert J.A., Khder, Yasser

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Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1 von Unterreiner, Adeline, Rubert, Joëlle, Kauffmann, Muriel, Fruhauf, Alice, Heiser, Diane, Erbel, Paulus, Schlapbach, Achim, Eder, Jörg, Bodendorf, Ursula, Boettcher, Andreas, Farady, Christopher J., Bornancin, Frédéric

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Small-molecule factor D inhibitors targeting the alternative complement pathway von Maibaum, Jürgen, Liao, Sha-Mei, Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Hughes, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Mac Sweeney, Aengus, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart, Anna, Jaffee, Bruce, Harrison, Richard, Risitano, Antonio Maria, Eder, Jörg, Anderson, Karen

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Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer von Emmons, Tiffany R, Giridharan, Thejaswini, Singel, Kelly L, Khan, Anm Nazmul H, Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L, Debreceni, Ivy L, Aarts, Cathelijn E M, Brouwer, Mieke C, Suzuki, Sora, Kuijpers, Taco W, Jongerius, Ilse, Allen, Lee-Ann H, Ferreira, Viviana P, Schubart, Anna, Sellner, Holger, Eder, Jörg, Holland, Steven M, Ram, Sanjay, Lederer, James A, Eng, Kevin H, Moysich, Kirsten B, Odunsi, Kunle, Yaffe, Michael B, Zsiros, Emese, Segal, Brahm H

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Src Stimulates Fibroblast Growth Factor Receptor-2 Shedding by an ADAM15 Splice Variant Linked to Breast Cancer von MARETZKY, Thorsten, LE GALL, Sylvain M, WORPENBERG-PIETRUK, Susanne, ELDER, Jörg, OVERALL, Christopher M, HUANG, Xin-Yun, POGHOSYAN, Zaruhi, EDWARDS, Dylan R, BLOBEL, Carl P

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macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target von Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Simić, Oliver, Kamke, Marion, Monnet, Gaby, Hassiepen, Ulrich, Svergun, Dmitri I, Pulfer, Ruth, Eder, Jörg, Raman, Prakash, Bodendorf, Ursula

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Opportunities and challenges in phenotypic drug discovery: an industry perspective von Moffat, John G., Vincent, Fabien, Lee, Jonathan A., Eder, Jörg, Prunotto, Marco

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Low‐molecular weight inhibitors of the alternative complement pathway von Schubart, Anna, Flohr, Stefanie, Junt, Tobias, Eder, Jörg

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Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK von Waelchli, Rudolf, Bollbuck, Birgit, Bruns, Christian, Buhl, Thomas, Eder, Jörg, Feifel, Roland, Hersperger, Rene, Janser, Philipp, Revesz, Laszlo, Zerwes, Hans-Günter, Schlapbach, Achim

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases von Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Sweeney, Aengus Mac, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg

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Pro‐sequence‐assisted protein folding von Eder, Jörg, Fersht, Alan R.

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Folding of subtilisin BPN': characterization of a folding intermediate von Eder, Jorg, Rheinnecker, Michael, Fersht, Alan R

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable... von Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G, Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A, Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W, Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M, Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Jürgen, Eder, Jörg, Sedrani, Richard, Harrison, Richard A, Mogi, Muneto, Jaffee, Bruce D, Adams, Christopher M

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Folding of Subtilisin BPN': Role of the Pro-sequence von Eder, Jörg, Rheinnecker, Michael, Fersht, Alan R.

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Tumour necrosis factor α and interleukin 1 signalling: do MAPKK kinases connect it all? von Eder, J.

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Factor XI antibodies and methods of use von Hassiepen, Ulrich, Schiering, Nikolaus, Melkko, Samu, Eder, Jorg, Khder, Yasser, Ewert, Stefan, Mayr, Lorenz M

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Stable substructures of eightfold βα-barrel proteins : fragment complementation of phosphoribosylanthranilate isomerase von EDER, J, KIRSCHNER, K

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