A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties von Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.

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Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12 von Lewis, Nuruddeen D., Sia, Chang Ling, Kirwin, Katherine, Haupt, Sonya, Mahimkar, Gauri, Zi, Tong, Xu, Ke, Dooley, Kevin, Jang, Su Chul, Choi, Bryan, Boutin, Adam, Grube, Andrew, McCoy, Christine, Sanchez-Salazar, Jorge, Doherty, Michael, Gaidukov, Leonid, Estes, Scott, Economides, Kyriakos D., Williams, Douglas E., Sathyanarayanan, Sriram

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A luminal epithelial stem cell that is a cell of origin for prostate cancer von Yu, Hailong, Abate-Shen, Cory, Halili, M. Vivienne, Walker, David, Shen, Michael M, Wang, Xi, Price, Sandy M, Julio, Marianna Kruithof-de, Hu, Ya-Ping, Economides, Kyriakos D

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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance von Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram

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Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities von Vohidov, Farrukh, Andersen, Jannik N, Economides, Kyriakos D, Shipitsin, Michail V, Burenkova, Olga, Ackley, James C, Vangamudi, Bhavatarini, Nguyen, Hung V.-T, Gallagher, Nolan M, Shieh, Peyton, Golder, Matthew R, Liu, Jenny, Dahlberg, William K, Ehrlich, Deborah J. C, Kim, Julie, Kristufek, Samantha L, Huh, Sung Jin, Neenan, Allison M, Baddour, Joelle, Paramasivan, Sattanathan, de Stanchina, Elisa, KC, Gaurab, Turnquist, David J, Saucier-Sawyer, Jennifer K, Kopesky, Paul W, Brady, Samantha W, Jessel, Michael J, Reiter, Lawrence A, Chickering, Donald E, Johnson, Jeremiah A, Blume-Jensen, Peter

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LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation[S] von Pipper, Cornelia, Bordag, Natalie, Reiter, Bernadette, Economides, Kyriakos, Florian, Peter, Birngruber, Thomas, Sinner, Frank, Bodenlenz, Manfred, Eberl, Anita

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Hoxb13 is required for normal differentiation and secretory function of the ventral prostate von Economides, Kyriakos D, Capecchi, Mario R

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Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs von Golder, Matthew R., Liu, Jenny, Andersen, Jannik N., Shipitsin, Michail V., Vohidov, Farrukh, Nguyen, Hung V.-T., Ehrlich, Deborah C., Huh, Sung Jin, Vangamudi, Bhavatarini, Economides, Kyriakos D., Neenan, Allison M., Ackley, James C., Baddour, Joelle, Paramasivan, Sattanathan, Brady, Samantha W., Held, Eric J., Reiter, Lawrence A., Saucier-Sawyer, Jennifer K., Kopesky, Paul W., Chickering, Donald E., Blume-Jensen, Peter, Johnson, Jeremiah A.

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Hoxb13 mutations cause overgrowth of caudal spinal cordand tail vertebrae von Economides, Kyriakos D, Zeltser, Lori, Capecchi, Mario R

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1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules von Subramanian, Kulandayan K, Chopra, Sameer, Morris, Kristin, Nirschl, Christopher J, Domonkos, Celesztina, Economides, Kyriakos, Salmeron, Andres, Seidel-Dugan, Cynthia, Isaacs, Randi, Hicklin, Daniel J

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252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors von Dwyer, Connor J, Brodkin, Heather R, Donovan, Olivia G, Economides, Kyriakos, Hicklin, Daniel J, LePrevost, Julie, Morris, Kristin, Seidel-Dugan, Cynthia, Winston, William M, Salmeron, Andres

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1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer von Sullivan, Jenna M, Aderhold, Pam, Brodkin, Heather R, Nagy-Domonkos, Celesztina, Economides, Kyriakos, Hicklin, Daniel J, Ismail, Nesreen, Seidel-Dugan, Cynthia, Winston, William M, Salmeron, Andres

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Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice von Vasistha, Navneet A., Johnstone, Mandy, Barton, Samantha K., Mayerl, Steffen E., Thangaraj Selvaraj, Bhuvaneish, Thomson, Pippa A., Dando, Owen, Grünewald, Ellen, Alloza, Clara, Bastin, Mark E., Livesey, Matthew R., Economides, Kyriakos, Magnani, Dario, Makedonopolou, Paraskevi, Burr, Karen, Story, David J., Blackwood, Douglas H. R., Wyllie, David J. A., McIntosh, Andrew M., Millar, J. Kirsty, ffrench-Constant, Charles, Hardingham, Giles E., Lawrie, Stephen M., Chandran, Siddharthan

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PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein von Lee, Hansol, Quinn, John C, Prasanth, Kannanganattu V, Swiss, Victoria A, Economides, Kyriakos D, Camacho, Marie M, Spector, David L, Abate-Shen, Cory

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Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases von ABATE-SHEN, Cory, BANACH-PETROSKY, Whitney A, XIAOHUI SUN, ECONOMIDES, Kyriakos D, DESAI, Nishita, GREGG, Jeffery P, BOROWSKY, Alexander D, CARDIFF, Robert D, SHEN, Michael M

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DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness von Malavasi, Elise L. V., Economides, Kyriakos D., Grünewald, Ellen, Makedonopoulou, Paraskevi, Gautier, Philippe, Mackie, Shaun, Murphy, Laura C., Murdoch, Hannah, Crummie, Darragh, Ogawa, Fumiaki, McCartney, Daniel L., O’Sullivan, Shane T., Burr, Karen, Torrance, Helen S., Phillips, Jonathan, Bonneau, Marion, Anderson, Susan M., Perry, Paul, Pearson, Matthew, Constantinides, Costas, Davidson-Smith, Hazel, Kabiri, Mostafa, Duff, Barbara, Johnstone, Mandy, Polites, H. Greg, Lawrie, Stephen M., Blackwood, Douglas H., Semple, Colin A., Evans, Kathryn L., Didier, Michel, Chandran, Siddharthan, McIntosh, Andrew M., Price, David J., Houslay, Miles D., Porteous, David J., Millar, J. Kirsty

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761 exoSTING demonstrates potent anti-tumor activity in a mouse model of leptomeningeal disease von Feng, Xudong, Lin, John, Jang, Su Chul, Lule, Sevda, Sanchez-Jauregui, Paloma, Kirwin, Katherine, Zi, Tong, Kasera, Samuel, Siso, Silvia, Zhang, Kelvin, Patel, Shil, Sathyanarayanan, Sriram, Economides, Kyriakos, Broom, Wendy

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842 Exosome mediated reprogramming of tumor associated macrophages by exoASO-STAT6 for the treatment of hepatocellular carcinoma (HCC) von Kamerkar, Sushrut, Leng, Charan, Zhang, Kelvin, Burenkova, Olga, Jang, Su Chul, Kasera, Samuel, Zi, Tong, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanaryanan, Sriram

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572 Combination therapy of exoSTING, exoIL-12 activates systemic anti-tumor immunity von Kirwin, Katherine, Jang, Su Chul, Sia, Christine, Dooley, Kevin, Zi, Tong, Zhang, Kelvin, Liu, Yanyan, Economides, Kyriakos, Patel, Shil, Sathyanaryanan, Sriram

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The Central Cannabinoid CB1 Receptor Is Required for Diet-Induced Obesity and Rimonabant's Antiobesity Effects in Mice von Pang, Zhen, Wu, Nancy N., Zhao, Weiguang, Chain, David C., Schaffer, Erica, Zhang, Xin, Yamdagni, Preeti, Palejwala, Vaseem A., Fan, Chunpeng, Favara, Sarah G., Dressler, Holly M., Economides, Kyriakos D., Weinstock, Daniel, Cavallo, Jean S., Naimi, Souad, Galzin, Anne‐Marie, Guillot, Etienne, Pruniaux, Marie‐Pierre, Tocci, Michael J., Polites, H. Greg

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