Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family von Eckelman, Brendan P, Salvesen, Guy S, Scott, Fiona L

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The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases von Eckelman, Brendan P., Salvesen, Guy S.

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Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death von Nakamura, Tomohiro, Wang, Lei, Wong, Catherine C.L., Scott, Fiona L., Eckelman, Brendan P., Han, Xuemei, Tzitzilonis, Christos, Meng, Fanjun, Gu, Zezong, Holland, Emily A., Clemente, Arjay T., Okamoto, Shu-ichi, Salvesen, Guy S., Riek, Roland, Yates, John R., Lipton, Stuart A.

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Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9 von Denault, Jean-Bernard, Eckelman, Brendan P, Shin, Hwain, Pop, Cristina, Salvesen, Guy S

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Identification of a candidate therapeutic antibody for treatment of canine B-cell lymphoma von Rue, Sarah M., Eckelman, Brendan P., Efe, Jem A., Bloink, Kristin, Deveraux, Quinn L., Lowery, David, Nasoff, Marc

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INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses von Sulzmaier, Florian J, Kern, Nadja, Ahn, Sae Jeong, Polovina, Anya, Ho, Jason, Hussain, Abrahim, Cyprus, Garrett, Macedo, Chelsie, Pandit, Rajay, Crago, William, Rowell, Emily, Timmer, John C, Eckelman, Brendan P

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Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody von Razai, Amir S., Eckelman, Brendan P., Salvesen, Guy S.

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Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP von Vucic, Domagoj, Franklin, Matthew C, Wallweber, Heidi J A, Das, Kanad, Eckelman, Brendan P, Shin, Hwain, Elliott, Linda O, Kadkhodayan, Saloumeh, Deshayes, Kurt, Salvesen, Guy S, Fairbrother, Wayne J

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Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma von Subbiah, Vivek, Chawla, Sant P, Conley, Anthony P, Wilky, Breelyn A, Tolcher, Anthony, Lakhani, Nehal J, Berz, David, Andrianov, Vasily, Crago, William, Holcomb, Monica, Hussain, Abrahim, Veldstra, Carson, Kalabus, James, O'Neill, Brianne, Senne, Lane, Rowell, Emily, Heidt, Analeah B, Willis, Katelyn M, Eckelman, Brendan P

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Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody von Narla, Rama Krishna, Modi, Hardik, Bauer, Daniel, Abbasian, Mahan, Leisten, Jim, Piccotti, Joseph R., Kopytek, Stephan, Eckelman, Brendan P., Deveraux, Quinn, Timmer, John, Zhu, Dan, Wong, Lilly, Escoubet, Laure, Raymon, Heather K., Hariharan, Kandasamy

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The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition von Shin, Hwain, Renatus, Martin, Eckelman, Brendan P, Nunes, Viviane A, Sampaio, Claudio A M, Salvesen, Guy S

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Recombinant Alpha-1 Antitrypsin-Fc Fusion Protein INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency: A Phase 1 Study von Brantly, Mark L, Kuhn, Brooks T, Farah, Humam W, Mahadeva, Ravi, Cole, Alexandra, Chang, Catherina L, Brown, Cynthia D, Campos, Michael A, Lascano, Jorge E, Babcock, Erin K, Bhagwat, Sharvari P, Boyea, Teresa F, Veldstra, Carson A, Andrianov, Vasily, Kalabus, James L, Eckelman, Brendan P, Veale, Andrew G

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Abstract 3513: INBRX-121, a safe and efficacious molecular targeted cytokine that enhances NK cell-mediated tumor killing von Kinkead, Heather, Sulzmaier, Florian J., Polovina, Anya, Kern, Nadja, Sanabria, Angelica, Ho, Jason, Macedo, Chelsie, Henderson, Ryan, Hussain, Abrahim, Pandit, Rajay, Crago, William, Rowell, Emily, Eckelman, Brendan P.

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Abstract 613: Development of FPA154, a novel tetravalent anti-GITR antibody, for the treatment of solid tumors von Barbee, Susannah D., Chen, Amanda, Johnson, Susan, Bellovin, David I., Timmer, John C., Wondyfraw, Nebiyu, Mkrtichyan, Mikayel, Razai, Amir S., Jones, Kyle S., Hata, Chelsie Y., Gonzalez, Denise, Deveraux, Quinn, Eckelman, Brendan P., Borges, Luis

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Abstract 2912: INBRX-130, a 5T4-targeted CONTRA-MAB, is a potent CD3 bispecific antibody engineered to have minimal off-tumor activity von Willis, Katelyn M., Haerr, Margaret, Meza, Marchelle, Ahn, Sae Jeong, Kaplan, Michael, Ortiz-Barquero, Georgina, Pandit, Rajay, Abalos, Rafael, Chen, Yao, Holley, Samuel, Lozano, Raul, Hwang, Iljin, Rowell, Emily, Eckelman, Brendan P.

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Abstract 4694: The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo von Narla, Rama Krishna, Modi, Hardik, Wong, Lilly, Abassian, Mahan, Bauer, Daniel, Desai, Pragnya, Gaffney, Bonny, Jackson, Pilgrim, Leisten, Jim, Liu, Jing, Lopez-Girona, Antonia, Romero, Maria, Yang, WenQing, Eckelman, Brendan P., Deveraux, Quinn, Phillips, Laurie, Raymon, Heather K., Escoubet, Laure, Boylan, John, Hariharan, Kandasamy

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DR5 AGONIST AND IAP ANTAGONIST COMBINATION THERAPY von CRAGO, William, HOLCOMB, Monica, WILLIS, Katelyn M, ECKELMAN, Brendan P

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DR5 AGONIST AND PLK1 INHIBITOR OR CDK INHIBITOR COMBINATION THERAPY von CRAGO, William, WILLIS, Katelyn M, ECKELMAN, Brendan P

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Type iii secretion system targeting molecules von Timmer, John C, Eckelman, Brendan P, Deveraux, Quinn, Hollands, Andrew

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CLEC12a binding polypeptides and uses thereof von Timmer, John C, Rascon, Lucas, Eckelman, Brendan P, Sanabria, Angelica

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