The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models von Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1 von Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monot... von Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz

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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 von Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole

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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5 von Nguyen, Duy, Lemos, Clara, Wortmann, Lars, Eis, Knut, Holton, Simon J, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Weiske, Joerg, Lechner, Christian, Prechtl, Stefan, Suelzle, Detlev, Siegel, Franziska, Prinz, Florian, Lesche, Ralf, Nicke, Barbara, Nowak-Reppel, Katrin, Himmel, Herbert, Mumberg, Dominik, von Nussbaum, Franz, Nising, Carl F, Bauser, Marcus, Haegebarth, Andrea

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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies von Berger, Markus, Wortmann, Lars, Buchgraber, Philipp, Lücking, Ulrich, Zitzmann-Kolbe, Sabine, Wengner, Antje M, Bader, Benjamin, Bömer, Ulf, Briem, Hans, Eis, Knut, Rehwinkel, Hartmut, Bartels, Florian, Moosmayer, Dieter, Eberspächer, Uwe, Lienau, Philip, Hammer, Stefanie, Schatz, Christoph A, Wang, Qiuwen, Wang, Qi, Mumberg, Dominik, Nising, Carl F, Siemeister, Gerhard

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase von Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus

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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis von Santamaria, Anna, Neef, Rüdiger, Eberspächer, Uwe, Eis, Knut, Husemann, Manfred, Mumberg, Dominik, Prechtl, Stefan, Schulze, Volker, Siemeister, Gerhard, Wortmann, Lars, Barr, Francis A, Nigg, Erich A

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Abstract 1470: Preclinical activity of the first reversible, potent and selective inhibitor of EGFR exon 20 insertions von Siegel, Franziska, Siegel, Stephan, Graham, Keith, Kaplan, Bethany, Petersen, Kirstin, Boemer, Ulf, Eberspaecher, Uwe, Korr, Daniel, Moenning, Ursula, Suelzle, Detlev, Schroeder, Jens, Prinz, Florian, Zitzmann-Kolbe, Sabine, Karsli-Uzunbas, Gizem, Lewis, Timothy, Hermsen, Mario, Cherniack, Andrew, von Nussbaum, Franz, Eis, Knut, Meyerson, Matthew, Greulich, Heidi

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Abstract 1722: Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1 von Leder, Gabriele, Carretero, Rafael, Mowat, Jeffrey, Berndt, Sandra, Neuhaus, Roland, Font, Nuria Aiguabella, Boemer, Ulf, von Ahsen, Oliver, Eberspaecher, Uwe, Guenther, Judith, Grees, Mareike, Link, Corinna, Nicke, Barbara, Baumann, Daniel, Schaefer, Martina, Oezcan-Wahlbrink, Mine, Werbeck, Nicolas D., Hartung, Ingo, Kreft, Bertolt, Offringa, Rienk

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Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target von Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo

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Abstract 4989: 3D spheroid screen yields SCD1 pathway inhibitors for the treatment of cancer von Gruenewald, Sylvia, Sperl, Carolyn, Steigemann, Patrick, Walter, Alexander, Zacharias, Sylvia, Eberspaecher, Uwe, Neuhaus, Roland, Zorn, Ludwig, Schwede, Wolfgang, Thede, Kai, Christian, Sven

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Identification of Small Molecules that Modulate Mutant p53 Condensation von Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick

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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A von Friberg, Anders, Rehwinkel, Hartmut, Nguyen, Duy, Pütter, Vera, Quanz, Maria, Weiske, Jörg, Eberspächer, Uwe, Heisler, Iring, Langer, Gernot

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Mouse androgen-dependent epididymal glycoprotein crisp-1 (DE/AEG): Isolation, biochemical characterization, and expression in recombinant form von Eberspaecher, Uwe, Roosterman, Dirk, Krätzschmar, Jörn, Haendler, Bernard, Habenicht, Ursula-Friederike, Becker, Andreas, Quensel, Christina, Petri, Thomas, Schleuning, Wolf-Dieter, Donner, Peter

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Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase MK2 von Hillig, Roman C., Eberspaecher, Uwe, Monteclaro, Felipe, Huber, Martina, Nguyen, Duy, Mengel, Anne, Muller-Tiemann, Beate, Egner, Ursula

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Identifying protein construct variants with increased crystallization propensity––A case study von Malawski, Guido A., Hillig, Roman C., Monteclaro, Felipe, Eberspaecher, Uwe, Schmitz, Arndt A.P., Crusius, Kerstin, Huber, Martina, Egner, Ursula, Donner, Peter, Müller‐Tiemann, Beate

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Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin von Bandeiras, Tiago M., Hillig, Roman Christian, Matias, Pedro M., Eberspaecher, Uwe, Fanghänel, Jörg, Thomaz, Mónica, Miranda, Sandra, Crusius, Kerstin, Pütter, Vera, Amstutz, Patrick, Gulotti-Georgieva, Maya, Binz, H. Kaspar, Holz, Caterina, Schmitz, Arndt A. P., Lang, Christine, Donner, Peter, Egner, Ursula, Carrondo, Maria A., Müller-Tiemann, Beate

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The Human Cysteine‐Rich Secretory Protein (CRISP) Family von Krätzschmar, Jörn, Haendler, Bernard, Eberspaecher, Uwe, Roosterman, Dirk, Donner, Peter, Schleuning, Wolf‐Dieter

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