TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism von Pan, Xiaojing, Eathiraj, Sudharshan, Munson, Mary, Lambright, David G.

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Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation von Hall, Terence G, Yu, Yi, Eathiraj, Sudharshan, Wang, Yunxia, Savage, Ronald E, Lapierre, Jean-Marc, Schwartz, Brian, Abbadessa, Giovanni

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Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092 von Yu, Yi, Savage, Ronald E, Eathiraj, Sudharshan, Meade, Justin, Wick, Michael J, Hall, Terence, Abbadessa, Giovanni, Schwartz, Brian

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Discovery of 3‑(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl‑3H‑imidazo[4,5‑b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhib... von Lapierre, Jean-Marc, Eathiraj, Sudharshan, Vensel, David, Liu, Yanbin, Bull, Cathy O, Cornell-Kennon, Susan, Iimura, Shin, Kelleher, Eugene W, Kizer, Darin E, Koerner, Steffi, Makhija, Sapna, Matsuda, Akihisa, Moussa, Magdi, Namdev, Nivedita, Savage, Ronald E, Szwaya, Jeff, Volckova, Erika, Westlund, Neil, Wu, Hui, Schwartz, Brian

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Structural basis for Rab GTPase recognition and endosome tethering by the C₂H₂ zinc finger of Early Endosomal Autoantigen 1 (EEA1) von Mishra, Ashwini, Eathiraj, Sudharshan, Corvera, Silvia, Lambright, David G

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Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphoryl... von Eathiraj, Sudharshan, Palma, Rocio, Volckova, Erika, Hirschi, Marscha, France, Dennis S., Ashwell, Mark A., Chan, Thomas C.K.

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Preclinical evaluation of combination nemtabrutinib and venetoclax in chronic lymphocytic leukemia von Muhowski, Elizabeth M, Ravikrishnan, Janani, Gordon, Britten, Yu, Lianbo, Misra, Shrilekha, Walker, Brandi, Eathiraj, Sudharshan, Sampath, Deepa, Rogers, Kerry A, Byrd, John C, Woyach, Jennifer A

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Structural basis of family-wide Rab GTPase recognition by rabenosyn-5 von Eathiraj, Sudharshan, Pan, Xiaojing, Ritacco, Christopher, Lambright, David G.

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The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs von Soncini, Debora, Orecchioni, Stefania, Ruberti, Samantha, Minetto, Paola, Martinuzzi, Claudia, Agnelli, Luca, Todoerti, Katia, Cagnetta, Antonia, Miglino, Maurizio, Clavio, Marino, Contini, Paola, Varaldo, Riccardo, Bergamaschi, Micaela, Guolo, Fabio, Passalacqua, Mario, Nencioni, Alessio, Monacelli, Fiammetta, Gobbi, Marco, Neri, Antonino, Abbadessa, Giovanni, Eathiraj, Sudharshan, Schwartz, Brian, Bertolini, Francesco, Lemoli, Roberto M, Cea, Michele

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Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes von Eathiraj, Sudharshan, Mishra, Ashwini, Prekeris, Rytis, Lambright, David G.

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Preclinical efficacy for a novel tyrosine kinase inhibitor, ArQule 531 against acute myeloid leukemia von Elgamal, Ola A, Mehmood, Abeera, Jeon, Jae Yoon, Carmichael, Bridget, Lehman, Amy, Orwick, Shelley J, Truxall, Jean, Goettl, Virginia M, Wasmuth, Ronni, Tran, Minh, Mitchell, Shaneice, Lapalombella, Rosa, Eathiraj, Sudharshan, Schwartz, Brian, Stegmaier, Kimberly, Baker, Sharyn D, Hertlein, Erin, Byrd, John C

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Structural Basis for Endosomal Targeting by FYVE Domains von Hayakawa, Akira, Hayes, Susan J., Lawe, Deirdre C., Sudharshan, Eathiraj, Tuft, Richard, Fogarty, Kevin, Lambright, David, Corvera, Silvia

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Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity von Sharma, Madhav D., Pacholczyk, Rafal, Shi, Huidong, Berrong, Zuzana J., Zakharia, Yousef, Greco, Austin, Chang, Chang-Sheng S., Eathiraj, Sudharshan, Kennedy, Eugene, Cash, Thomas, Bollag, Roni J., Kolhe, Ravindra, Sadek, Ramses, McGaha, Tracy L., Rodriguez, Paulo, Mandula, Jessica, Blazar, Bruce R., Johnson, Theodore S., Munn, David H.

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Determinants of Rab5 Interaction with the N Terminus of Early Endosome Antigen 1 von Merithew, Eric, Stone, Craig, Eathiraj, Sudharshan, Lambright, David G

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The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation von Reiff, Sean D, Mantel, Rose, Smith, Lisa L, Greene, J T, Muhowski, Elizabeth M, Fabian, Catherine A, Goettl, Virginia M, Tran, Minh, Harrington, Bonnie K, Rogers, Kerry A, Awan, Farrukh T, Maddocks, Kami, Andritsos, Leslie, Lehman, Amy M, Sampath, Deepa, Lapalombella, Rosa, Eathiraj, Sudharshan, Abbadessa, Giovanni, Schwartz, Brian, Johnson, Amy J, Byrd, John C, Woyach, Jennifer A

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In-vitro and in-vivo combined effect of ARQ 092, an AKT inhibitor, with ARQ 087, a FGFR inhibitor von Yu, Yi, Hall, Terence, Eathiraj, Sudharshan, Wick, Michael J, Schwartz, Brian, Abbadessa, Giovanni

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A phase 1 study to assess BDTX-1535, an oral EGFR inhibitor, in patients with glioblastoma or non–small-cell lung cancer von Johnson, Melissa Lynne, Henry, Jason Timothy, Spira, Alexander I., Battiste, James, Alnahhas, Iyad, Ahluwalia, Manmeet Singh, Barve, Minal A., Edenfield, William Jeffery, Nam, Do-Hyun, Eathiraj, Sudharshan, Hajdenberg, Julio, Yurasov, Sergey, Yu, Helena Alexandra, Wen, Patrick Y.

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First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non-Hodgkin Lymphoma von Woyach, Jennifer A, Stephens, Deborah M, Flinn, Ian W, Bhat, Seema A, Savage, Ronald E, Chai, Feng, Eathiraj, Sudharshan, Reiff, Sean D, Muhowski, Elizabeth M, Granlund, Lindsey, Szuszkiewicz, Lyndsey, Wang, Wayne, Schwartz, Brian, Ghori, Razi, Farooqui, Mohammed Z H, Byrd, John C

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Abstract 2943: In vivo combination of miransertib (ARQ 092) with anti-PD-1 antibody, trametinib, lapatinib, trastuzumab and paclitaxel von Yu, Yi, Hall, Terence, Eathiraj, Sudharshan, Savage, Ron E., Schwartz, Brian

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Abstract 4797: In vitro and in vivo effect of ARQ 531 on Trk family kinases von Yu, Yi, Schwartz, Gabi, Schamber, Pascal, Savage, Ron E., Eathiraj, Sudharshan, Hall, Terence, Schwartz, Brian

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