SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Ac... von Neerukonda, Sabari Nath, Vassell, Russell, Lusvarghi, Sabrina, Wang, Richard, Echegaray, Fernando, Bentley, Lisa, Eakin, Ann E., Erlandson, Karl J., Katzelnick, Leah C., Weiss, Carol D., Wang, Wei

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Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents von Eakin, Ann E, Green, Oluyinka, Hales, Neil, Walkup, Grant K, Bist, Shanta, Singh, Alok, Mullen, George, Bryant, Joanna, Embrey, Kevin, Gao, Ning, Breeze, Alex, Timms, Dave, Andrews, Beth, Uria-Nickelsen, Maria, Demeritt, Julie, Loch, James T., III, Hull, Ken, Blodgett, April, Illingworth, Ruth N, Prince, Bryan, Boriack-Sjodin, P. Ann, Hauck, Sheila, MacPherson, Lawrence J, Ni, Haihong, Sherer, Brian

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In Vivo Activity of Amodiaquine against Ebola Virus Infection von DeWald, Lisa Evans, Johnson, Joshua C., Gerhardt, Dawn M., Torzewski, Lisa M., Postnikova, Elena, Honko, Anna N., Janosko, Krisztina, Huzella, Louis, Dowling, William E., Eakin, Ann E., Osborn, Blaire L., Gahagen, Janet, Tang, Liang, Green, Carol E., Mirsalis, Jon C., Holbrook, Michael R., Jahrling, Peter B., Dyall, Julie, Hensley, Lisa E.

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Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo von MILLS, Scott D, EAKIN, Ann E, WEI YANG, STOKES, Suzanne S, BUURMAN, Ed T, NEWMAN, Joseph V, NING GAO, HUYNH, Hoan, JOHNSON, Kenneth D, LAHIRI, Sushmita, SHAPIRO, Adam B, WALKUP, Grant K

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Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans von Bulitta, Jürgen B, Hope, William W, Eakin, Ann E, Guina, Tina, Tam, Vincent H, Louie, Arnold, Drusano, George L, Hoover, Jennifer L

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Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model von Connolly, Kristie L, Eakin, Ann E, Gomez, Carolina, Osborn, Blaire L, Unemo, Magnus, Jerse, Ann E

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Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects von Lusvarghi, Sabrina, Wang, Wei, Herrup, Rachel, Neerukonda, Sabari Nath, Vassell, Russell, Bentley, Lisa, Eakin, Ann E, Erlandson, Karl J, Weiss, Carol D

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Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection mode... von Lodise, Thomas P, Smith, Nicolas M, O’Donnell, Nick, Eakin, Ann E, Holden, Patricia N, Boissonneault, Katie Rose, Zhou, Jieqiang, Tao, Xun, Bulitta, Jürgen B, Fowler, Vance G, Chambers, Henry F, Bonomo, Robert A, Tsuji, Brian T

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Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam von Singh, Renu, Kim, Aryun, Tanudra, M Angela, Harris, Jennifer J, McLaughlin, Robert E, Patey, Sara, O'Donnell, John P, Bradford, Patricia A, Eakin, Ann E

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Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents von Basarab, Gregory S, Manchester, John I, Bist, Shanta, Boriack-Sjodin, P. Ann, Dangel, Brian, Illingworth, Ruth, Sherer, Brian A, Sriram, Shubha, Uria-Nickelsen, Maria, Eakin, Ann E

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Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy von Kim, Aryun, Kutschke, Amy, Ehmann, David E, Patey, Sara A, Crandon, Jared L, Gorseth, Elise, Miller, Alita A, McLaughlin, Robert E, Blinn, Christina M, Chen, April, Nayar, Asha S, Dangel, Brian, Tsai, Andy S, Rooney, Michael T, Murphy-Benenato, Kerry E, Eakin, Ann E, Nicolau, David P

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Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099) von Basarab, Gregory S, Hill, Pamela J, Garner, C. Edwin, Hull, Ken, Green, Oluyinka, Sherer, Brian A, Dangel, P. Brian, Manchester, John I, Bist, Shanta, Hauck, Sheila, Zhou, Fei, Uria-Nickelsen, Maria, Illingworth, Ruth, Alm, Richard, Rooney, Mike, Eakin, Ann E

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Evaluation of a panel of therapeutic antibody clinical candidates for efficacy against SARS-CoV-2 in Syrian hamsters von Cong, Yu, Mucker, Eric M., Perry, Donna L., Dixit, Saurabh, Kollins, Erin, Byrum, Russ, Huzella, Louis, Kim, Robert, Josleyn, Mathew, Kwilas, Steven, Stefan, Christopher, Shoemaker, Charles J., Koehler, Jeff, Coyne, Susan, Delp, Korey, Liang, Janie, Drawbaugh, David, Hischak, Amanda, Hart, Randy, Postnikova, Elena, Vaughan, Nick, Asher, Jason, St Claire, Marisa, Hanson, Jarod, Schmaljohn, Connie, Eakin, Ann E., Hooper, Jay W., Holbrook, Michael R.

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Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus von Cong, Yu, Dyall, Julie, Hart, Brit J, DeWald, Lisa Evans, Johnson, Joshua C, Postnikova, Elena, Zhou, Huanying, Gross, Robin, Rojas, Oscar, Alexander, Isis, Josleyn, Nicole, Zhang, Tengfei, Michelotti, Julia, Janosko, Krisztina, Glass, Pamela J, Flint, Mike, McMullan, Laura K, Spiropoulou, Christina F, Mierzwa, Tim, Guha, Rajarshi, Shinn, Paul, Michael, Sam, Klumpp-Thomas, Carleen, McKnight, Crystal, Thomas, Craig, Eakin, Ann E, O'Loughlin, Kathleen G, Green, Carol E, Catz, Paul, Mirsalis, Jon C, Honko, Anna N, Olinger, Jr, Gene G, Bennett, Richard S, Holbrook, Michael R, Hensley, Lisa E, Jahrling, Peter B

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Approaching the Transition State in the Crystal Structure of a Phosphoribosyltransferase von Focia, Pamela J, Craig, Sydney P, Eakin, Ann E

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Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase von Canyuk, Bhutorn, Medrano, Francisco J, Wenck, Mary Anne, Focia, Pamela J, Eakin, Ann E, Craig, 3rd, Sydney P

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Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy von Sherer, Brian A., Hull, Kenneth, Green, Oluyinka, Basarab, Gregory, Hauck, Sheila, Hill, Pamela, Loch, James T., Mullen, George, Bist, Shanta, Bryant, Joanna, Boriack-Sjodin, Ann, Read, Jon, DeGrace, Nancy, Uria-Nickelsen, Maria, Illingworth, Ruth N., Eakin, Ann E.

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A High-Throughput Fluorescence Resonance Energy Transfer-Based Assay for DNA Ligase von Shapiro, Adam B., Eakin, Ann E., Walkup, Grant K., Rivin, Olga

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Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase von Lee, Christian C, J. Medrano, Francisco, Craig, Sydney P, Eakin, Ann E

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Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi von Wenck, Mary Anne, Medrano, Francisco J, Eakin, Ann E, Craig, Sydney P

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