A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends... von Lanieri, Leanne, Lamothe, Tahirih L, Miske, Oliver, McDonough, Sean M, Sarma, Ganapathy N, Bhattarai, Prashant, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Palchaudhuri, Rahul, Knihtila, Ryan, Pearse, Bradley R, Proctor, Jennifer L, Boitano, Anthony E, Cooke, Michael P, Davis, John C.

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A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning... von Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Panwar, Rajiv, Sarma, Ganapathy N, Kien, Lena, Dushime, Junia, Adams, Hillary L., Hyzy, Sharon L., Brooks, Melissa, Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, Lamothe, Tahirih L, Jain, Nidhi, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry von Liu, Renpeng, Chen, Xuan, Dushime, Junia, Bogalhas, Megan, Lazar, Alexandru C, Ryll, Thomas, Wang, Lintao

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A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates von Tisdale, John F., Donahue, Robert E., Uchida, Naoya, Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Krouse, Allen, Linde, Nathaniel S., Bonifacino, Aylin C., Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning von Palchaudhuri, Rahul, Pearse, Bradley R, Proctor, Jennifer L, Hyzy, Sharon L., Aslanian, Sharon, McDonough, Sean M, Sarma, Ganapathy, Brooks, Melissa L., Bhat, Anjali, Ladwig, Danielle, McShea, Molly A, Kallen, Nathan M, Li, Qing, Panwar, Rajiv, Dushime, Junia, Sawant, Pranoti, Adams, Hillary L, Falahee, Patrick C., Lamothe, Tahirih L, Gabros, Andrew D, Kien, Lena, Gillard, Geoff, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L, Hyzy, Sharon L., Adams, Hillary L, Brooks, Melissa L., Gabros, Andrew D, McDonough, Sean M, Kien, Lena, Aslanian, Sharon, Pearse, Bradley R, Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sarma, Ganapathy, McShea, Molly A, Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Tran... von Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Panwar, Rajiv, Sarma, Ganapathy, McShea, Molly A, Kien, Lena, Dushime, Junia, Adams, Hillary L, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Kallen, Nathan M, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends... von Lanieri, Leanne, Lamothe, Tahirih L., Mikse, Oliver, McDonough, Sean M., Sarma, Ganapathy N., Bhattarai, Prashant raj, Latimer, Kellie, Dushime, Junia, Jain, Nidhi, Knihtila, Ryan, Palchaudhuri, Rahul, Pearse, Bradley R., Boitano, Anthony E., Cooke, Michael P., Davis, John C, Olson, Lisa M, Proctor, Jennifer L.

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A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window a... von Pearse, Bradley R., Proctor, Jennifer L., McDonough, Sean M., Panwar, Rajiv, Sarma, Ganapathy N., Neale, Jason, Kien, Lena, Dushime, Junia, Latimer, Kellie, Lamothe, Tahirih L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Jain, Nidhi, Knihtila, Ryan, McDonagh, Charlotte F., Boitano, Anthony E., Davis, John C., Cooke, Michael P.

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A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates von Uchida, Naoya, Tisdale, John F., Donahue, Robert E., Pearse, Bradley R., McDonough, Sean M., Proctor, Jennifer L., Krouse, Allen E, Linde, Nathaniel, Bonifacino, Aylin, Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L., Hyzy, Sharon L., Adams, Hillary L., Brooks, Melissa, Gabros, Andrew D., McDonough, Sean M., Kien, Lena, Aslanian, Sharon, Pearse, Bradley R., Palchaudhuri, Rahul, Li, Qing, Sarma, Ganapathy N., Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models von Proctor, Jennifer L., Hyzy, Sharon L., Adams, Hillary L., Brooks, Melissa, Gabros, Andrew D., McDonough, Sean M., Kien, Lena, Aslanian, Sharon, Pearse, Bradley R., Palchaudhuri, Rahul, Li, Qing, Sarma, Ganapathy N., Ladwig, Danielle, Dushime, Junia, Panwar, Rajiv, McDonagh, Charlotte F., Boitano, Anthony E., Cooke, Michael P.

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Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells von Palchaudhuri, Rahul, Pearse, Brad R., Proctor, Jennifer L., Hyzy, Sharon L., Aslanian, Sharon, Bhat, Anjali, Gillard, Geoff O, McDonough, Sean M., Sarma, Ganapathy N, Ladwig, Danielle, Li, Qing, Jain, Nidhi, Panwar, Rajiv, Sawant, Pranoti, Dushime, Junia, Falahee, Patrick C., Kien, Lena, Lamothe, Tahirih L, Gabros, Andrew D, Adams, Hillary L., McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.

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The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry von Liu, Renpeng, Chen, Xuan, Dushime, Junia, Bogalhas, Megan, Lazar, Alexandru C., Ryll, Thomas, Wang, Lintao

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