Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity von Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John J., Gough, Peter J.

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Construction of 3D-QSAR Models Using the 4D-QSAR Analysis Formalism von Hopfinger, A. J, Wang, Shen, Tokarski, John S, Jin, Baiqiang, Albuquerque, Magaly, Madhav, Prakash J, Duraiswami, Chaya

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Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity von Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John, Gough, Peter J.

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemia von Okoye-Okafor, Ujunwa C, Bartholdy, Boris, Cartier, Jessy, Gao, Enoch N, Pietrak, Beth, Rendina, Alan R, Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J, Reif, Alexander J, Schmidt, Stanley J, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-Rao, Antony-Debre, Iléana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D, Schwartz, Benjamin, McCabe, Michael T, Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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A Tale of Two Subunits: How the Neomorphic R132H IDH1 Mutation Enhances Production of αHG von Pietrak, Beth, Zhao, Huizhen, Qi, Hongwei, Quinn, Chad, Gao, Enoch, Boyer, Joseph G, Concha, Nestor, Brown, Kristin, Duraiswami, Chaya, Wooster, Richard, Sweitzer, Sharon, Schwartz, Benjamin

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Mutant IDH1 Enhances the Production of 2‑Hydroxyglutarate Due to Its Kinetic Mechanism von Rendina, Alan R, Pietrak, Beth, Smallwood, Angela, Zhao, Huizhen, Qi, Hongwei, Quinn, Chad, Adams, Nicholas D, Concha, Nestor, Duraiswami, Chaya, Thrall, Sara H, Sweitzer, Sharon, Schwartz, Benjamin

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Discovery and electrophysiological characterization of SKF-32802: A novel hERG agonist found through a large-scale structural similarity search von Donovan, Brian T., Bandyopadhyay, Deepak, Duraiswami, Chaya, Nixon, Christopher J., Townsend, Claire Y., Martens, Stan F.

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High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome von Harris, Philip A., Duraiswami, Chaya, Fisher, Donald T., Fornwald, James, Hoffman, Sandra J., Hofmann, Glenn, Jiang, Ming, Lehr, Ruth, McCormick, Patricia M., Nickels, Leng, Schwartz, Benjamin, Wu, Zining, Zhang, Guofeng, Marquis, Robert W., Bertin, John, Gough, Peter J.

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Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel (vol 9, pg 1039, 2018) von Haile, Pamela A., Casillas, Linda N., Bury, Michael J., Mehlmann, John F., Singhaus, Robert, Charnley, Adam K., Hughes, Terry V., DeMartino, Michael P., Wang, Gren Z., Romano, Joseph J., Dong, Xiaoyang, Plotnikov, Nikolay V., Lakdawala, Ami S., Duraiswami, Chaya, Convery, Maire A., Votta, Bartholomew J., Lipshutz, David B., Desai, Biva M., Swift, Barbara, Capriotti, Carol A., Berger, Scott B., Mahajan, Mukesh K., Reilly, Michael A., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T., Totoritis, Rachel D., Donovan, Brian T., Brown, Barry S., Chaudhary, Khuram W., Gough, Peter J., Bertin, John, Marquis, Robert W.

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New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia von Okoye-Okafor, Ujunwa Cynthia, Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Ken, Reif, Alexander, Schmidt, Stan, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Narayanagari, Swathi-rao, Antony-Debre, Ileana, Mitchell, Kelly, Carvajal, Luis, Wang, Heng Rui, Barreyro, Laura, Kao, Yun-Ruei, Christopeit, Maximilian, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas, Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslaw P., Verma, Amit, Steidl, Ulrich

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Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel von Haile, Pamela A., Casillas, Linda N., Bury, Michael J., Mehlmann, John F., Singhaus, Robert, Charnley, Adam K., Hughes, Terry V., DeMartino, Michael P., Wang, Gren Z., Romano, Joseph J., Dong, Xiaoyang, Plotnikov, Nikolay V., Lakdawala, Ami S., Duraiswami, Chaya, Convery, Maire A., Votta, Bartholomew J., Lipshutz, David B., Desai, Biva M., Swift, Barbara, Capriotti, Carol A., Berger, Scott B., Mahajan, Mukesh K., Reilly, Michael A., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, LePage, Carol, Ouellette, Michael T., Totoritis, Rachel D., Donovan, Brian T., Brown, Barry S., Chaudhary, Khuram W., Gough, Peter J., Bertin, John, Marquis, Robert W.

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemiaf von Okoye-oka, Ujunwa C, Bartholdy, Boris, Cartier, Jessy, Gao, Enoch N, Pietrak, Beth, Rendina, Alan R, Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J, Reif, Alexander J, Schmidt, Stanley J, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-rao, Antony-debre, Iléana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D, Schwartz, Benjamin, Mccabe, Michael T, Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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Abstract C38: Novel allosteric IDH1 mutant Inhibitors for differentiation therapy of acute myeloid leukemia von Okoye-Okafor, Ujunwa C., Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Ken, Reif, Alexander, Schmidt, Stan, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Narayanagari, Swathi-Rao, Antony-Debre, Ileana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Will, Britta, Concha, Nestor, Adams, Nicholas D., Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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Novel IDH1 Mutant Inhibitors for Treatment of Acute Myeloid Leukemia von Okoye-Okafor, Ujunwa C., Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J., Reif, Alexander J., Schmidt, Stanley J., Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-Rao, Antony-Debre, Ileana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D., Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors von Totoritis, Rachel, Duraiswami, Chaya, Taylor, Amy N, Kerrigan, John J, Campobasso, Nino, Smith, Katherine J, Ward, Paris, King, Bryan W, Murrayz-Thompson, Monique, Jones, Amber D, Van Aller, Glenn S, Aubart, Kelly M, Zalacain, Magdalena, Thrall, Sara H, Meek, Thomas D, Schwartz, Benjamin

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Synthesis and SAR of potent LXR agonists containing an indole pharmacophore von Washburn, David G., Hoang, Tram H., Campobasso, Nino, Smallwood, Angela, Parks, Derek J., Webb, Christine L., Frank, Kelly A., Nord, Melanie, Duraiswami, Chaya, Evans, Christopher, Jaye, Michael, Thompson, Scott K.

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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists von Thompson, Scott K., Washburn, David G., Frazee, James S., Madauss, Kevin P., Hoang, Tram H., Lapinski, Leahann, Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Williams, Shawn P., Duraiswami, Chaya, Bray, Jeffrey D., Laping, Nicholas J.

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2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3- b]pyridine derivatives as selective progesterone receptor agonists von Wang, Yonghui, Duraiswami, Chaya, Madauss, Kevin P., Tran, Thuy B., Williams, Shawn P., Deng, Su-Jun, Graybill, Todd L., Hammond, Marlys, Jones, David G., Grygielko, Eugene T., Bray, Jeffrey D., Thompson, Scott K.

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Improving the developability profile of pyrrolidine progesterone receptor partial agonists von Kallander, Lara S., Washburn, David G., Hoang, Tram H., Frazee, James S., Stoy, Patrick, Johnson, Latisha, Lu, Qing, Hammond, Marlys, Barton, Linda S., Patterson, Jaclyn R., Azzarano, Leonard M., Nagilla, Rakesh, Madauss, Kevin P., Williams, Shawn P., Stewart, Eugene L., Duraiswami, Chaya, Grygielko, Eugene T., Xu, Xiaoping, Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.

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Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists von Washburn, David G., Hoang, Tram H., Frazee, James S., Johnson, Latisha, Hammond, Marlys, Manns, Sharada, Madauss, Kevin P., Williams, Shawn P., Duraiswami, Chaya, Tran, Thuy B., Stewart, Eugene L., Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Nagilla, Rakesh, Bray, Jeffrey D., Thompson, Scott K.

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