Machine learning approach informs biology of cancer drug response von Zhu, Eliot Y, Dupuy, Adam J

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The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis von DeZwaan-McCabe, Diane, Riordan, Jesse D, Arensdorf, Angela M, Icardi, Michael S, Dupuy, Adam J, Rutkowski, D Thomas

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Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors von Brett, Benjamin T, Berquam-Vrieze, Katherine E, Nannapaneni, Kishore, Huang, Jian, Scheetz, Todd E, Dupuy, Adam J

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Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis von Riordan, Jesse D, Keng, Vincent W, Tschida, Barbara R, Scheetz, Todd E, Bell, Jason B, Podetz-Pedersen, Kelly M, Moser, Catherine D, Copeland, Neal G, Jenkins, Nancy A, Roberts, Lewis R, Largaespada, David A, Dupuy, Adam J

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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis von Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.

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Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma von Mann, Karen M., Ward, Jerrold M., Yew, Christopher Chin Kuan, Kovochich, Anne, Dawson, David W., Black, Michael A., Brett, Benjamin T., Sheetz, Todd E., Dupuy, Adam J., Chang, David K., Biankin, Andrew V., Waddell, Nicola, Kassahn, Karin S., Grimmond, Sean M., Rust, Alistair G., Adams, David J., Jenkins, Nancy A., Copeland, Neal G.

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Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice von Riordan, Jesse D., Feddersen, Charlotte R., Tschida, Barbara R., Beckmann, Pauline J., Keng, Vincent W., Linden, Michael A., Amin, Khalid, Stipp, Christopher S., Largaespada, David A., Dupuy, Adam J.

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Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function von Guimarães-Young, Amy, Neff, Traci, Dupuy, Adam J., Goodheart, Michael J.

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Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer von Starr, Timothy K, Allaei, Raha, Silverstein, Kevin A.T, Staggs, Rodney A, Sarver, Aaron L, Bergemann, Tracy L, Gupta, Mihir, O'Sullivan, M. Gerard, Matise, Ilze, Dupuy, Adam J, Collier, Lara S, Powers, Scott, Oberg, Ann L, Asmann, Yan W, Thibodeau, Stephen N, Tessarollo, Lino, Copeland, Neal G, Jenkins, Nancy A, Cormier, Robert T, Largaespada, David A

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Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors von Tschida, Barbara R, Temiz, Nuri A, Kuka, Timothy P, Lee, Lindsey A, Riordan, Jesse D, Tierrablanca, Carlos A, Hullsiek, Robert, Wagner, Sandra, Hudson, Wendy A, Linden, Michael A, Amin, Khalid, Beckmann, Pauline J, Heuer, Rachel A, Sarver, Aaron L, Yang, Ju Dong, Roberts, Lewis R, Nadeau, Joseph H, Dupuy, Adam J, Keng, Vincent W, Largaespada, David A

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Transposon-based screens for cancer gene discovery in mouse models von Dupuy, Adam J

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The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity von Rauckhorst, Adam J., Gray, Lawrence R., Sheldon, Ryan D., Fu, Xiaorong, Pewa, Alvin D., Feddersen, Charlotte R., Dupuy, Adam J., Gibson-Corley, Katherine N., Cox, James E., Burgess, Shawn C., Taylor, Eric B.

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Clonal selection drives genetic divergence of metastatic medulloblastoma von Wu, Xiaochong, Northcott, Paul A., Dubuc, Adrian, Dupuy, Adam J., Shih, David J. H., Witt, Hendrik, Croul, Sidney, Bouffet, Eric, Fults, Daniel W., Eberhart, Charles G., Garzia, Livia, Van Meter, Timothy, Zagzag, David, Jabado, Nada, Schwartzentruber, Jeremy, Majewski, Jacek, Scheetz, Todd E., Pfister, Stefan M., Korshunov, Andrey, Li, Xiao-Nan, Scherer, Stephen W., Cho, Yoon-Jae, Akagi, Keiko, MacDonald, Tobey J., Koster, Jan, McCabe, Martin G., Sarver, Aaron L., Collins, V. Peter, Weiss, William A., Largaespada, David A., Collier, Lara S., Taylor, Michael D.

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A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer von Suárez-Cabrera, Cristian, Quintana, Rita M, Bravo, Ana, Casanova, M Llanos, Page, Angustias, Alameda, Josefa P, Paramio, Jesús M, Maroto, Alicia, Salamanca, Javier, Dupuy, Adam J, Ramírez, Angel, Navarro, Manuel

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Aberrant Epithelial–Mesenchymal Hedgehog Signaling Characterizes Barrett's Metaplasia von Wang, David H, Clemons, Nicholas J, Miyashita, Tomoharu, Dupuy, Adam J, Zhang, Wei, Szczepny, Anette, Corcoran–Schwartz, Ian M, Wilburn, Daniel L, Montgomery, Elizabeth A, Wang, Jean S, Jenkins, Nancy A, Copeland, Neal A, Harmon, John W, Phillips, Wayne A, Watkins, D. Neil

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RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens von Temiz, Nuri A, Moriarity, Branden S, Wolf, Natalie K, Riordan, Jesse D, Dupuy, Adam J, Largaespada, David A, Sarver, Aaron L

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A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells von Feddersen, Charlotte R, Wadsworth, Lexy S, Zhu, Eliot Y, Vaughn, Hayley R, Voigt, Andrew P, Riordan, Jesse D, Dupuy, Adam J

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Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis von Vaishnavi, Aria, Juan, Joseph, Jacob, Maebh, Stehn, Christopher, Gardner, Eric E, Scherzer, Michael T, Schuman, Sophia, Van Veen, J Edward, Murphy, Brandon, Hackett, Christopher S, Dupuy, Adam J, Chmura, Steven A, van der Weyden, Louise, Newberg, Justin Y, Liu, Annie, Mann, Karen, Rust, Alistair G, Weiss, William A, Kinsey, Conan G, Adams, David J, Grossmann, Allie, Mann, Michael B, McMahon, Martin

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Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer von Schachter, Nathan F., Adams, Jessica R., Skowron, Patryk, Kozma, Katelyn. J., Lee, Christian A., Raghuram, Nandini, Yang, Joanna, Loch, Amanda J., Wang, Wei, Kucharczuk, Aaron, Wright, Katherine L., Quintana, Rita M., An, Yeji, Dotzko, Daniel, Gorman, Jennifer L., Wojtal, Daria, Shah, Juhi S., Leon-Gomez, Paul, Pellecchia, Giovanna, Dupuy, Adam J., Perou, Charles M., Ben-Porath, Ittai, Karni, Rotem, Zacksenhaus, Eldad, Woodgett, Jim R., Done, Susan J., Garzia, Livia, Sorana Morrissy, A., Reimand, Jüri, Taylor, Michael D., Egan, Sean E.

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A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging von Buchakjian, Marisa R, Merritt, Nicole M, Moose, Devon L, Dupuy, Adam J, Tanas, Munir R, Henry, Michael D

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