Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches von Duong, MyLinh T., Collinson-Pautz, Matthew R., Morschl, Eva, Lu, An, Szymanski, Slawomir P., Zhang, Ming, Brandt, Mary E., Chang, Wei-Chun, Sharp, Kelly L., Toler, Steven M., Slawin, Kevin M., Foster, Aaron E., Spencer, David M., Bayle, J. Henri

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LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients von Duong, MyLinh T, Akli, Said, Wei, Caimiao, Wingate, Hannah F, Liu, Wenbin, Lu, Yiling, Yi, Min, Mills, Gordon B, Hunt, Kelly K, Keyomarsi, Khandan

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Changes in Apparent Free Energy of Helix–Helix Dimerization in a Biological Membrane Due to Point Mutations von Duong, Mylinh T., Jaszewski, Todd M., Fleming, Karen G., MacKenzie, Kevin R.

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RAP1: Protector of Telomeres, Defender against Obesity von Duong, MyLinh T., Sahin, Ergün

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Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies von Caruso, Joseph A, Duong, Mylinh T, Carey, Jason P W, Hunt, Kelly K, Keyomarsi, Khandan

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Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40 von Foster, Aaron E., Mahendravada, Aruna, Shinners, Nicholas P., Chang, Wei-Chun, Crisostomo, Jeannette, Lu, An, Khalil, Mariam, Morschl, Eva, Shaw, Joanne L., Saha, Sunandan, Duong, MyLinh T., Collinson-Pautz, Matthew R., Torres, David L., Rodriguez, Tania, Pentcheva-Hoang, Tsvetelina, Bayle, J. Henri, Slawin, Kevin M., Spencer, David M.

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Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells von DUONG, Mylinh T, AKLI, Said, MACALOU, Sira, BIERNACKA, Anna, DEBEB, Bisrat G, MIN YI, HUNT, Kelly K, KEYOMARSI, Khandan

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Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants von Samuel, Errol L.G, Duong, MyLinh T, Bitner, Brittany R, Marcano, Daniela C, Tour, James M, Kent, Thomas A

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Abstract 2194: Inducible MyD88/CD40 (iMC) enhances CAR-T cell expansion and persistence by overcoming T cell exhaustion von Duong, MyLinh T., Mahendravada, Aruna, Brandt, Mary E., Sharp, Kelly L., Foster, Aaron E., Bayle, J. Henri

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Preclinical Development of Inducible MyD88/CD40 (iMC)-Enhanced Chimeric Antigen Receptor Natural Killer (GoCAR-NK) Cells to Target BCMA+ Tumors von Wang, Xiaomei, Duong, MyLinh T, Guerrero, Alan D., Mahendravada, Aruna, Sharp, Kelly L, Brandt, Mary E., Gagliardi, Christine, Foster, Aaron E., Bayle, J. Henri

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Abstract LB-184: Dual-switchGoCAR-T cells: small molecule-regulated “GO” and “STOP” switches to target solid cancer in vivo von Duong, MyLinh T., Collinson-Pautz, Matthew R., Morschl, Eva, Brandt, Mary E., Zhang, Ming, Slawin, Kevin W., Foster, Aaron E., Bayle, J. Henri, Spencer, David M.

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Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123+ Cancer von Bayle, J. Henri, Duong, MyLinh T, Lu, An, Morschl, Eva, Collinson-Pautz, Matthew R., Sharp, Kelly L, Szymanski, Slawomir, Brandt, Mary E., Slawin, Kevin M., Toler, Steven, Yvon, Eric, Foster, Aaron, Spencer, David M.

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Abstract 3745: Dual-switch TCR: A two-ligand system to control PRAME TCR-modified T cell proliferation and death using inducible MyD88/CD40 and caspase-9 von Pentcheva-Hoang, Tsvetelina, Rodriguez, Tania, Torres, David, Korngold, Ana, Crisostomo, Jeannette, Duong, MyLinh T., Collinson-Pautz, Matthew, Bayle, J. Henri, Heemskerk, Mirjam HM, Falkenburg, J.H. Frederik, Moseley, Annemarie, Slawin, Kevin M., Spencer, David, Foster, Aaron E.

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Abstract A057: Uni-CIDeCAR-T cells: MyD88/CD40-enhanced, Ab-directed CAR incorporating the CaspaCIDe® safety switch von Duong, MyLinh T., Collinson-Pautz, Matthew R., Foster, Aaron E., Bayle, J. Henri, Spencer, David M.

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Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies von Collinson-Pautz, Matthew R., Chang, Wei-Chun, Lu, An, Khalil, Mariam, Crisostomo, Jeannette W., Lin, Pei-Yi, Mahendravada, Aruna, Shinners, Nicholas P., Brandt, Mary E., Zhang, Ming, Duong, MyLinh, Bayle, J. Henri, Slawin, Kevin M., Spencer, David M., Foster, Aaron E.

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External validation of the 4C mortality score among COVID-19 patients admitted to hospital in Ontario, Canada: a retrospective study von Jones, Aaron, Pitre, Tyler, Junek, Mats, Kapralik, Jessica, Patel, Rina, Feng, Edward, Dawson, Laura, Tsang, Jennifer L. Y., Duong, MyLinh, Ho, Terence, Beauchamp, Marla K., Costa, Andrew P., Kruisselbrink, Rebecca

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Associations between lung function and physical and cognitive health in the Canadian Longitudinal Study on Aging (CLSA): A cross-sectional study from a multicenter national cohort von Duong, MyLinh, Usman, Ali, Ma, Jinhui, Xie, Yangqing, Huang, Julie, Zaman, Michele, Dragoman, Alex, Jiatong Chen, Steven, Farooqi, Malik, Raina, Parminder

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Health Effects of Household Solid Fuel Use: Findings from 11 Countries within the Prospective Urban and Rural Epidemiology Study von Hystad, Perry, Duong, MyLinh, Brauer, Michael, Larkin, Andrew, Arku, Raphael, Kurmi, Om P, Fan, Wen Qi, Avezum, Alvaro, Azam, Igbal, Chifamba, Jephat, Dans, Antonio, du Plessis, Johan L, Gupta, Rajeev, Kumar, Rajesh, Lanas, Fernando, Liu, Zhiguang, Lu, Yin, Lopez-Jaramillo, Patricio, Mony, Prem, Mohan, Viswanathan, Mohan, Deepa, Nair, Sanjeev, Puoane, Thandi, Rahman, Omar, Lap, Ah Tse, Wang, Yanga, Wei, Li, Yeates, Karen, Rangarajan, Sumathy, Teo, Koon, Yusuf, Salim

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Impact of electronic cigarette ever use on lung function in adults aged 45–85: a cross-sectional analysis from the Canadian Longitudinal Study on Aging von Joshi, Divya, Duong, MyLinh, Kirkland, Susan, Raina, Parminder

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Protein expression of SARS-CoV-2 receptors ACE2 and TMPRSS2 in allergic airways after allergen challenge von Whetstone, Christiane E, Ranjbar, Maral, Cusack, Ruth P, Al-Sajee, Dhuha, Omer, Hafsa, Alsaji, Nadia, Ho, Terence, Duong, MyLinh, Mitchell, Patrick, Satia, Imran, Keith, Paul, Xie, Yanqing, MacLean, Jonathan, Sommer, Doron D, O'Byrne, Paul M, Sehmi, Roma, Gauvreau, Gail M

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