Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1 von Penzes, Peter, Houslay, Miles D, Brandon, Nicholas J, Murdoch, Hannah, Hayashi-Takagi, Akiko, Dunlop, Allan J, Graziane, Nick, Sawa, Akira, Makino, Yuichi, Yan, Zhen, Ishizuka, Koko, Takaki, Manabu, Xie, Zhong, Srivastava, Deepak P, Kamiya, Atsushi, Seshadri, Anupamaa J, Seshadri, Saurav, Baraban, Jay M, Tomoda, Toshifumi

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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ von Perino, Alessia, Ghigo, Alessandra, Ferrero, Enrico, Morello, Fulvio, Santulli, Gaetano, Baillie, George S, Damilano, Federico, Dunlop, Allan J, Pawson, Catherine, Walser, Romy, Levi, Renzo, Altruda, Fiorella, Silengo, Lorenzo, Langeberg, Lorene K, Neubauer, Gitte, Heymans, Stephane, Lembo, Giuseppe, Wymann, Matthias P, Wetzker, Reinhard, Houslay, Miles D, Iaccarino, Guido, Scott, John D, Hirsch, Emilio

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p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway von Sachs, Benjamin D, Baillie, George S, McCall, Julianne R, Passino, Melissa A, Schachtrup, Christian, Wallace, Derek A, Dunlop, Allan J, MacKenzie, Kirsty F, Klussmann, Enno, Lynch, Martin J, Sikorski, Shoana L, Nuriel, Tal, Tsigelny, Igor, Zhang, Jin, Houslay, Miles D, Chao, Moses V, Akassoglou, Katerina

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Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression von Sheppard, Catherine L., Lee, Louisa C.Y., Hill, Elaine V., Henderson, David J.P., Anthony, Diana F., Houslay, Daniel M., Yalla, Krishna C., Cairns, Lynne S., Dunlop, Allan J., Baillie, George S., Huston, Elaine, Houslay, Miles D.

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DISC1-dependent switch from progenitor proliferation to migration in the developing cortex von Ishizuka, Koko, Kamiya, Atsushi, Oh, Edwin C., Kanki, Hiroaki, Seshadri, Saurav, Robinson, Jon F., Murdoch, Hannah, Dunlop, Allan J., Kubo, Ken-ichiro, Furukori, Keiko, Huang, Beverly, Zeledon, Mariela, Hayashi-Takagi, Akiko, Okano, Hideyuki, Nakajima, Kazunori, Houslay, Miles D., Katsanis, Nicholas, Sawa, Akira

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Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains von Bolger, Graeme B., Dunlop, Allan J., Meng, Dong, Day, Jon P., Klussmann, Enno, Baillie, George S., Adams, David R., Houslay, Miles D.

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Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species von Xu, Tian-Rui, Vyshemirsky, Vladislav, Gormand, Amélie, von Kriegsheim, Alex, Girolami, Mark, Baillie, George S, Ketley, Dominic, Dunlop, Allan J, Milligan, Graeme, Houslay, Miles D, Kolch, Walter

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Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function von Murdoch, Hannah, Vadrevu, Suryakiran, Prinz, Anke, Dunlop, Allan J, Klussmann, Enno, Bolger, Graeme B, Norman, James C, Houslay, Miles D

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Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA) von Collins, Daniel M., Murdoch, Hannah, Dunlop, Allan J., Charych, Erik, Baillie, George S., Wang, Qi, Herberg, Friedrich W., Brandon, Nicholas, Prinz, Anke, Houslay, Miles D.

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Determination of Cotinine by LC-MS-MS with Automated Solid-Phase Extraction von Dunlop, Allan J., Clunie, Iain, Stephen, Duncan W.S., Allison, James J.

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A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex von Li, Xiang, MacLeod, Ruth, Dunlop, Allan J., Edwards, Helen V., Advant, Noopur, Gibson, Lucien C.D., Devine, Nicola M., Brown, Kim M., Adams, David R., Houslay, Miles D., Baillie, George S.

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Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species von Xu, Tian-Rui, Vyshemirsky, Vladislav, Gormand, Amélie, von Kriegsheim, Alex, Girolami, Mark, Baillie, George S, Ketley, Dominic, Dunlop, Allan J, Milligan, Graeme, Houslay, Miles D, Kolch, Walter

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1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling s... von Smith, K. John, Baillie, George S., Hyde, Eva I., Li, Xiang, Houslay, Thomas M., McCahill, Angela, Dunlop, Allan J., Bolger, Graeme B., Klussmann, Enno, Adams, David R., Houslay, Miles D.

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Integrating Cardiac PIP 3 and cAMP Signaling through a PKA Anchoring Function of p110γ von Perino, Alessia, Ghigo, Alessandra, Ferrero, Enrico, Morello, Fulvio, Santulli, Gaetano, Baillie, George S., Damilano, Federico, Dunlop, Allan J., Pawson, Catherine, Walser, Romy, Levi, Renzo, Altruda, Fiorella, Silengo, Lorenzo, Langeberg, Lorene K., Neubauer, Gitte, Heymans, Stephane, Lembo, Giuseppe, Wymann, Matthias P., Wetzker, Reinhard, Houslay, Miles D., Iaccarino, Guido, Scott, John D., Hirsch, Emilio

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Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment von Kirin, Mirna, Chandra, Aman, Charteris, David G, Hayward, Caroline, Campbell, Susan, Celap, Ivana, Bencic, Goran, Vatavuk, Zoran, Kirac, Iva, Richards, Allan J, Tenesa, Albert, Snead, Martin P, Fleck, Brian W, Singh, Jaswinder, Harsum, Steven, Maclaren, Robert E, den Hollander, Anneke I, Dunlop, Malcolm G, Hoyng, Carel B, Wright, Alan F, Campbell, Harry, Vitart, Veronique, Mitry, Danny

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853 The TOPPIC Trial: A Randomized, Double-Blind Parallel Group Trial of Mercaptopurine vs Placebo to Prevent Recurrence of Crohn's Disease Following Surgical Resection in 240 Pati... von Arnott, Ian, Mowat, Craig, Ennis, Holly, Keerie, Catriona, Lewis, Steff, Kennedy, Nicholas, Cahill, Aidan, Morris, Allan J, Dunlop, Malcolm, Bloom, Stuart, Lindsay, James O, Subramanian, Sreedhar, Satsangi, Jack

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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis von Freitag, DF, Howson, JMM, Burgess, S, Ho, WK, Wood, AM, Sweeting, M, Spackman, S, Staley, JR, Ramond, A, Harshfield, E, Nielsen, SF, Grande, P, Jones, GT, Scott, RA, Porcu, E, Thorleifsson, G, Zeng, L, Kessler, T, Do, R, Hopewell, JC, Kleber, M, Delgado, GE, Nelson, CP, Goel, A, Dehghan, A, Ligthart, S, Qu, L, Kuivaniemi, H, Ritchie, MD, Crawford, DC, Malinowski, J, De Andrade, M, Kullo, IJ, Peissig, PL, McCarty, CA, Gottesman, O, Pacheco, JA, Huang, J, Ala-Korpela, M, Mitchell, GF, Parsa, A, Wilkinson, IB, Li, Y, Keller, MF, Ganesh, SK, Bruijn, L, Brown, MA, Ferreira, MA, Weidinger, S, Franke, A, Felix, JF, Thompson, SD, Panoutsopoulou, K, Nalls, MA, Singleton, A, Polychronakos, C, Bradfield, JP, Hakonarson, H, Thompson, D, Dunlop, M, Hemminki, K, Morgan, G, Eisen, T, Goldschmidt, H, Allan, JM, Whiffin, N, Chubb, D, Houlston, RS, Bishop, DT, Law, MH, Nejentsev, S, Barbalic, M, Crossman, D, Soranzo, N, Wareham, NJ, Assimes, T, Harris, TB, Hofman, A, Franco, OH, Gudnason, V, Tracy, R, Psaty, BM, Hall, AS, Maerz, W, Collins, R, Kooner, JS, Chambers, JC, McPherson, R, Erdmann, J, Kastrati, A, Schunkert, H, Thorsteinsdottir, U, Walston, JD, Tybjaerg-Hansen, A, Alam, DS, Chowdhury, R, Nordestgaard, BG, Saleheen, D, Thompson, SG, Danesh, J

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