Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis von Newton, Kim, Wickliffe, Katherine E., Dugger, Debra L., Maltzman, Allie, Roose-Girma, Merone, Dohse, Monika, Kőműves, László, Webster, Joshua D., Dixit, Vishva M.

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Activity of caspase-8 determines plasticity between cell death pathways von Newton, Kim, Wickliffe, Katherine E., Maltzman, Allie, Dugger, Debra L., Reja, Rohit, Zhang, Yue, Roose-Girma, Merone, Modrusan, Zora, Sagolla, Meredith S., Webster, Joshua D., Dixit, Vishva M.

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Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis von Newton, Kim, Dugger, Debra L., Wickliffe, Katherine E., Kapoor, Neeraj, de Almagro, M. Cristina, Vucic, Domagoj, Komuves, Laszlo, Ferrando, Ronald E., French, Dorothy M., Webster, Joshua, Roose-Girma, Merone, Warming, Søren, Dixit, Vishva M.

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OTULIN limits cell death and inflammation by deubiquitinating LUBAC von Heger, Klaus, Wickliffe, Katherine E., Ndoja, Ada, Zhang, Juan, Murthy, Aditya, Dugger, Debra L., Maltzman, Allie, de Sousa e Melo, Felipe, Hung, Jeffrey, Zeng, Yi, Verschueren, Erik, Kirkpatrick, Donald S., Vucic, Domagoj, Lee, Wyne P., Roose-Girma, Merone, Newman, Robert J., Warming, Søren, Hsiao, Yi-Chun, Kőműves, László G., Webster, Joshua D., Newton, Kim, Dixit, Vishva M.

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Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1 von He, Meng, Chaurushiya, Mira S, Webster, Joshua D, Kummerfeld, Sarah, Reja, Rohit, Chaudhuri, Subhra, Chen, Ying-Jiun, Modrusan, Zora, Haley, Benjamin, Dugger, Debra L, Eastham-Anderson, Jeffrey, Lau, Shari, Dey, Anwesha, Caothien, Roger, Roose-Girma, Merone, Newton, Kim, Dixit, Vishva M

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Benchmarking high-resolution hydrologic model performance of long-term retrospective streamflow simulations in the contiguous United States von Towler, Erin, Foks, Sydney S, Dugger, Aubrey L, Dickinson, Jesse E, Essaid, Hedeff I, Gochis, David, Viger, Roland J, Zhang, Yongxin

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Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation von Zhang, Jieqiong, Webster, Joshua D., Dugger, Debra L., Goncharov, Tatiana, Roose-Girma, Merone, Hung, Jeffrey, Kwon, Youngsu C., Vucic, Domagoj, Newton, Kim, Dixit, Vishva M.

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β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1 von Suriben, Rowena, Kaihara, Kelly A., Paolino, Magdalena, Reichelt, Mike, Kummerfeld, Sarah K., Modrusan, Zora, Dugger, Debra L., Newton, Kim, Sagolla, Meredith, Webster, Joshua D., Liu, Jinfeng, Hebrok, Matthias, Dixit, Vishva M.

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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury von Newton, K, Dugger, D L, Maltzman, A, Greve, J M, Hedehus, M, Martin-McNulty, B, Carano, R A D, Cao, T C, van Bruggen, N, Bernstein, L, Lee, W P, Wu, X, DeVoss, J, Zhang, J, Jeet, S, Peng, I, McKenzie, B S, Roose-Girma, M, Caplazi, P, Diehl, L, Webster, J D, Vucic, D

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RIPK1 inhibits ZBP1-driven necroptosis during development von Newton, Kim, Wickliffe, Katherine E., Maltzman, Allie, Dugger, Debra L., Strasser, Andreas, Pham, Victoria C., Lill, Jennie R., Roose-Girma, Merone, Warming, Søren, Solon, Margaret, Ngu, Hai, Webster, Joshua D., Dixit, Vishva M.

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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury von Newton, K, Dugger, D L, Maltzman, A, Greve, J M, Hedehus, M, Martin-McNulty, B, Carano, R A D, Cao, T C, van Bruggen, N, Bernstein, L, Lee, W P, Wu, X, DeVoss, J, Zhang, J, Jeet, S, Peng, I, McKenzie, B S, Roose-Girma, M, Caplazi, P, Diehl, L, Webster, J D, Vucic, D

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Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia von Ndoja, Ada, Reja, Rohit, Lee, Seung-Hye, Webster, Joshua D., Ngu, Hai, Rose, Christopher M., Kirkpatrick, Donald S., Modrusan, Zora, Chen, Ying-Jiun Jasmine, Dugger, Debra L., Gandham, Vineela, Xie, Luke, Newton, Kim, Dixit, Vishva M.

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Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death von Kist, Matthias, Kőműves, László G., Goncharov, Tatiana, Dugger, Debra L., Yu, Charles, Roose-Girma, Merone, Newton, Kim, Webster, Joshua D., Vucic, Domagoj

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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases von Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj

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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate von Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X

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Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis von Newton, Kim, Wickliffe, Katherine E., Maltzman, Allie, Dugger, Debra L., Webster, Joshua D., Guo, Hongyan, Dixit, Vishva M.

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The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function von Oberbeck, Nina, Pham, Victoria C., Webster, Joshua D., Reja, Rohit, Huang, Christine S., Zhang, Yue, Roose-Girma, Merone, Warming, Søren, Li, Qingling, Birnberg, Andrew, Wong, Weng, Sandoval, Wendy, Kőműves, László G., Yu, Kebing, Dugger, Debra L., Maltzman, Allie, Newton, Kim, Dixit, Vishva M.

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Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer von JUNUTULA, Jagath R, FLAGELLA, Kelly M, MAI, Elaine, LEWIS PHILLIPS, Gail D, HIRARAGI, Hajime, FUJI, Reina N, TIBBITTS, Jay, VANDLEN, Richard, SPENCER, Susan D, SCHELLER, Richard H, POLAKIS, Paul, SLIWKOWSKI, Mark X, GRAHAM, Richard A, PARSONS, Kathryn L, HA, Edward, RAAB, Helga, BHAKTA, Sunil, NGUYEN, Trung, DUGGER, Debra L, GUANGMIN LI

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Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain von Newton, Kim, Dugger, Debra L., Sengupta-Ghosh, Arundhati, Ferrando, Ronald E., Chu, Felix, Tao, Janet, Lam, Wendy, Haller, Susan, Chan, Sara, Sa, Susan, Dunlap, Debra, Eastham-Anderson, Jeffrey, Ngu, Hai, Hung, Jeffrey, French, Dorothy M., Webster, Joshua D., Bolon, Brad, Liu, Jinfeng, Reja, Rohit, Kummerfeld, Sarah, Chen, Ying-Jiun, Modrusan, Zora, Lewcock, Joseph W., Dixit, Vishva M.

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Synergistic Induction of Tumor Antigens by Wnt-1 Signaling and Retinoic Acid Revealed by Gene Expression Profiling von Tice, David A., Szeto, Wayne, Soloviev, Irina, Rubinfeld, Bonnee, Fong, Sharon E., Dugger, Debra L., Winer, Jane, Williams, P. Mickey, Wieand, David, Smith, Victoria, Schwall, Ralph H., Pennica, Diane, Polakis, Paul

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