Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies von Acin‐Perez, Rebeca, Benincá, Cristiane, Fernandez del Rio, Lucia, Shu, Cynthia, Baghdasarian, Siyouneh, Zanette, Vanessa, Gerle, Christoph, Jiko, Chimari, Khairallah, Ramzi, Khan, Shaharyar, Rincon Fernandez Pacheco, David, Shabane, Byourak, Erion, Karel, Masand, Ruchi, Dugar, Sundeep, Ghenoiu, Cristina, Schreiner, George, Stiles, Linsey, Liesa, Marc, Shirihai, Orian S

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A Concise and Efficient Synthesis of Substituted Morpholines von Dugar, Sundeep, Sharma, Amit, Kuila, Bilash, Mahajan, Dinesh, Dwivedi, Sandeep, Tripathi, Vinayak

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Progressive transforming growth factor β1-induced lung fibrosis is blocked by an orally active alk5 kinase inhibitor von BONNIAUD, Philippe, MARGETTS, Peter J, PROTTER, Andrew A, GAULDIE, Jack, KOLB, Martin, SCHROEDER, Jane Ann, KAPOUN, Ann M, DAMM, Debby, MURPHY, Alison, CHAKRAVARTY, Sarvajit, DUGAR, Sundeep, HIGGINS, Linda

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SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer von Tran, Arthur-Quan, Sullivan, Stephanie A, Chan, Leo Li-Ying, Yin, Yajie, Sun, Wenchuan, Fang, Ziwei, Dugar, Sundeep, Zhou, Chunxiao, Bae-Jump, Victoria

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Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo von RONGRONG GE, RAJEEV, Vaishali, SCHREINER, George, BARNARD, Nicola, REISS, Michael, RAY, Partha, LATTIME, Edmund, RITTLING, Susan, MEDICHERLA, Satya, PROTTER, Andy, MURPHY, Alison, CHAKRAVARTY, Jit, DUGAR, Sundeep

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Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers von Barnett, Christopher F, Moreno-Ulloa, Aldo, Shiva, Sruti, Ramirez-Sanchez, Israel, Taub, Pam R, Su, Yongxuan, Ceballos, Guillermo, Dugar, Sundeep, Schreiner, George, Villarreal, Francisco

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Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness von Nath, Puneeta, Leung, Sum-Yee, Williams, Alison, Noble, Alistair, Chakravarty, Sundeep Dugar Sarvajit, Luedtke, Gregory R., Medicherla, Satyanarayana, Higgins, Linda S., Protter, Andrew, Chung, Kian Fan

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Outsourcing drug discovery to India and China: from surviving to thriving von Subramaniam, Swaminathan, Dugar, Sundeep

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Abstract 15690: Bioactive Fumarate Improves Cardiac Function and Expands Lifespan in Friedreich's Ataxia von Salinas, Lili, Figueroa, Francisco, Montgomery, Claire, Thai, Phung, Chiamvimonvat, Nipavan, Dugar, Sundeep, Sen, Somdutta, Cortopassi, Gino, Dedkova, Elena N

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Discovery and Development of SPR519 as a Potent, Selective, and Orally Bioavailable Inhibitor of PI3Kα and mTOR Kinases for the Treatment of Solid Tumors von Mahajan, Dinesh, Sen, Somdutta, Kuila, Bilash, Sharma, Amit, Arora, Reena, Sagar, Milind, Mahapatra, Amal Ray, Gawade, Lalita Babasaheb, Dugar, Sundeep

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(−)‐Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy von McDonald, Craig M., Ramirez‐Sanchez, Israel, Oskarsson, Björn, Joyce, Nanette, Aguilar, Candace, Nicorici, Alina, Dayan, Jonathan, Goude, Erica, Abresch, R. Ted, Villarreal, Francisco, Ceballos, Guillermo, Perkins, Guy, Dugar, Sundeep, Schreiner, George, Henricson, Erik K.

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Bioactive fumarate improves cardiac function and expands lifespan in Friedrech's ataxia von Salinas, Lili, Figueroa, Francisco, Montgomery, Claire B., Thai, Phung N., Chiamvimonvat, Nipavan, Dugar, Sundeep, Sen, Somdutta, Cortopassi, Gino, Dedkova, Elena N.

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A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceride... von Gutiérrez-Salmeán, Gabriela, Meaney, Eduardo, Lanaspa, Miguel A, Cicerchi, Christina, Johnson, Richard J, Dugar, Sundeep, Taub, Pam, Ramírez-Sánchez, Israel, Villarreal, Francisco, Schreiner, George, Ceballos, Guillermo

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11-β-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry von Dugar, Sundeep, Villarreal, Francisco, Hollinger, Frank H., Mahajan, Dinesh, Ramirez-Sanchez, Israel, Moreno-Ulloa, Aldo, Ceballos, Guillermo, Schreiner, George

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Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors von Dugar, Sundeep, Hollinger, Frank P., Kuila, Bilash, Arora, Reena, Sen, Somdutta, Mahajan, Dinesh

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Abstract LB196: SPR965, a PI3K/mTORC1/C2 inhibitor for treatment of chordoma von Dugar, Sundeep, Sen, Somdutta, Maffuid, Paul, Freed, Dan, Sommer, Josh, Anderson, Edward, Hickey, Anthony

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Clinical Pharmacokinetics and Preclinical Pharmacodynamics of (+)‐Epicatechin on Cardiometabolic Endpoints von Villarreal, Francisco, Moreno‐Ulloa, Aldo, Ciaraldi, Theodore, Best, Brookie, Ramirez‐Sanchez, Israel, Ceballos, Guillermo, Dugar, Sundeep, Schreiner, George, Henry, Robert

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Stimulatory effects of (−)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept von Navarrete-Yañez, Viridiana, Garate-Carrillo, Alejandra, Ayala, Marcos, Rodriguez-Castañeda, Antonio, Mendoza-Lorenzo, Patricia, Ceballos, Guillermo, Ordoñez-Razo, Rosa, Dugar, Sundeep, Schreiner, George, Villarreal, Francisco, Ramirez-Sanchez, Israel

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Stimulatory Effects of the Flavanols (−)‐Epicatechin and its Enantiomer (+)‐Epicatechin on Frontal Cortex Markers of Neurogenesis von Villarreal, Francisco, Mendoza‐Lorenzo, Patricia, Neri‐Gomez, Teresa, Manjarrez‐Gutierrez, Gabriel, Navarrete‐Yanez, Viridiana, Schreiner, George, Dugar, Sundeep, Ceballos, Guillermo, Ramirez‐Sanchez, Israel

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Synthetic approaches to the 6H-pyrido[4,3-b]carbazole alkaloids von Dugar, Sundeep

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