M281, an Anti‐FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First‐in‐Human Study von Ling, Leona E., Hillson, Jan L., Tiessen, Renger G., Bosje, Tjerk, Iersel, Mattheus Paulus, Nix, Darrell J., Markowitz, Lynn, Cilfone, Nicholas A., Duffner, Jay, Streisand, James B., Manning, Anthony M., Arroyo, Santiago

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Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles von Tassa, Carlos, Duffner, Jay L, Lewis, Timothy A, Weissleder, Ralph, Schreiber, Stuart L, Koehler, Angela N, Shaw, Stanley Y

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A small molecule that binds Hedgehog and blocks its signaling in human cells von Stanton, Benjamin Z, Peng, Lee F, Maloof, Nicole, Nakai, Kazuo, Wang, Xiang, Duffner, Jay L, Taveras, Kennedy M, Hyman, Joel M, Lee, Sam W, Koehler, Angela N, Chen, James K, Fox, Julia L, Mandinova, Anna, Schreiber, Stuart L

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Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity von Yang, Zemin, Johnson, Bryan A., Meliopoulos, Victoria A., Ju, Xiaohui, Zhang, Peipei, Hughes, Michael P., Wu, Jinjun, Koreski, Kaitlin P., Clary, Jemma E., Chang, Ti-Cheng, Wu, Gang, Hixon, Jeff, Duffner, Jay, Wong, Kathy, Lemieux, Rene, Lokugamage, Kumari G., Alvarado, R. Elias, Crocquet-Valdes, Patricia A., Walker, David H., Plante, Kenneth S., Plante, Jessica A., Weaver, Scott C., Kim, Hong Joo, Meyers, Rachel, Schultz-Cherry, Stacey, Ding, Qiang, Menachery, Vineet D., Taylor, J. Paul

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M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis von Zhou, He, Roy, Sucharita, Cochran, Edward, Zouaoui, Radouane, Chu, Chia Lin, Duffner, Jay, Zhao, Ganlin, Smith, Sean, Galcheva-Gargova, Zoya, Karlgren, Juliane, Dussault, Nancy, Kwan, Rain Y Q, Moy, Erick, Barnes, Marishka, Long, Alison, Honan, Chris, Qi, Yi Wei, Shriver, Zachary, Ganguly, Tanmoy, Schultes, Birgit, Venkataraman, Ganesh, Kishimoto, Takashi Kei

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A pipeline for ligand discovery using small-molecule microarrays von Duffner, Jay L, Clemons, Paul A, Koehler, Angela N

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Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor von Farutin, Victor, Prod'homme, Thomas, McConnell, Kevin, Washburn, Nathaniel, Halvey, Patrick, Etzel, Carol J, Guess, Jamey, Duffner, Jay, Getchell, Kristen, Meccariello, Robin, Gutierrez, Bryan, Honan, Christopher, Zhao, Ganlin, Cilfone, Nicholas A, Gunay, Nur Sibel, Hillson, Jan L, DeLuca, David S, Saunders, Katherine C, Pappas, Dimitrios A, Greenberg, Jeffrey D, Kremer, Joel M, Manning, Anthony M, Ling, Leona E, Capila, Ishan

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Equivalent Gene Expression Profiles between Glatopa™ and Copaxone von D'Alessandro, Josephine S, Duffner, Jay, Pradines, Joel, Capila, Ishan, Garofalo, Kevin, Kaundinya, Ganesh, Greenberg, Benjamin M, Kantor, Daniel, Ganguly, Tanmoy C

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Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity von Nieland, Thomas J. F, Shaw, Jared T, Jaipuri, Firoz A, Duffner, Jay L, Koehler, Angela N, Banakos, Sotirios, Zannis, Vassilis I, Kirchhausen, Tomas, Krieger, Monty

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Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5 von Orlando, Lianna R, Ayala, Ramses, Kett, Lauren R, Curley, Allison A, Duffner, Jay, Bragg, D. Cristopher, Tsai, Li-Huei, Dunah, Anthone W, Young, Anne B

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Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI von Nieland, Thomas J.F., Shaw, Jared T., Jaipuri, Firoz A., Maliga, Zoltan, Duffner, Jay L., Koehler, Angela N., Krieger, Monty

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Nipocalimab’s Selective Targeting of FcRn and IgG Clearance Preserves Key Immune Functions (P1-1.Virtual) von Ling, Leona E., Tyler, Steven, Beneduce, Christopher J., Brown, Julia, Kumar, Sujatha, Duffner, Jay, Avery, William

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Nipocalimab’s Selective Targeting of FcRn and IgG Clearance Preserves Key Immune Functions von Ling, Leona, Tyler, Steven, Beneduce, Christopher, Yu, Faye, Brown, Julia, Kumar, Sujatha, Xu, Rui, Duffner, Jay, Avery, William

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Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events von Sobolev, Olga, Binda, Elisa, O'Farrell, Sean, Lorenc, Anna, Pradines, Joel, Huang, Yongqing, Duffner, Jay, Schulz, Reiner, Cason, John, Zambon, Maria, Malim, Michael H, Peakman, Mark, Cope, Andrew, Capila, Ishan, Kaundinya, Ganesh V, Hayday, Adrian C

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Identification of small molecule inhibitors of G3BP-driven stress granule formation von Freibaum, Brian D, Messing, James, Nakamura, Haruko, Yurtsever, Ugur, Wu, Jinjun, Kim, Hong Joo, Hixon, Jeff, Lemieux, Rene Marc, Duffner, Jay, Huynh, Walter, Wong, Kathy, White, Michael, Lee, Christina, Meyers, Rachel E, Parker, Roy, Taylor, J Paul

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Pharmacokinetics and Pharmacodynamics of Nipocalimab, a Neonatal Fc Receptor Blocker, in Healthy Japanese Volunteers von Matsushima, Nobuko, Shibata, Sayori, Leu, Jocelyn H., Vermeulen, An, Duffner, Jay, Ling, Leona E., Schwartz, Lisa B., Harigae, Hideo

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Characterization of Endogenous Human FcγRIII by Mass Spectrometry Reveals Site, Allele and Sequence Specific Glycosylation[S] von Washburn, Nathaniel, Meccariello, Robin, Duffner, Jay, Getchell, Kristen, Holte, Kimberly, Prod'homme, Thomas, Srinivasan, Karunya, Prenovitz, Robert, Lansing, Jonathan, Capila, Ishan, Kaundinya, Ganesh, Manning, Anthony M., Bosques, Carlos J.

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Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies von Roy, Sucharita, El Hadri, Ahmed, Richard, Sebastien, Denis, Fanny, Holte, Kimberly, Duffner, Jay, Yu, Fei, Galcheva-Gargova, Zoya, Capila, Ishan, Schultes, Birgit, Petitou, Maurice, Kaundinya, Ganesh V

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Abstract 561: Discovery of a potential best-in-class anti-CD38 therapeutic utilizing Fc multimerization von Choudhury, Amit, Ortiz, Daniel F., Argueta, Shannon, Garofalo, Kevin, Lansing, Jonathan C., Jetley, Utsav, Wilkins, Danice, Bosques, Carlos, Cochran, Edward, Bhatnagar, Naveen, Duffner, Jay, Gupta, Abhinav, Lee, Stan, Srinivasan, Karunya, Parge, Viraj, Zouaoui, Radouane, Wang, Jason, Manning, Anthony M.

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Comparative Gene Expression Profiling between a Generic (M356) and Brand Copaxone® (glatiramer acetate injection) (P1.144) von D’Alessandro, Josephine, Duffner, Jay, Pradines, Joel, Honan, Christopher, Prod’homme, Thomas, Ganguly, Tanmoy, Kaundinya, Ganesh

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