Confirming the Source of High-Sulfate Concentrations in Dead Horse Creek, Winkler, Manitoba, Canada, Using a Dual-Isotope Bayesian Probability Mixing Model von Dubinsky, Adam J., Wilks, Rebecca P. A., Buhay, William M.

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Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives von Papamichael, Konstantinos, Afif, Waqqas, Drobne, David, Dubinsky, Marla C, Ferrante, Marc, Irving, Peter M, Kamperidis, Nikolaos, Kobayashi, Taku, Kotze, Paulo G, Lambert, Jo, Noor, Nurulamin M, Roblin, Xavier, Roda, Giulia, Vande Casteele, Niels, Yarur, Andres J, Arebi, Naila, Danese, Silvio, Paul, Stephane, Sandborn, William J, Vermeire, Séverine, Cheifetz, Adam S, Peyrin-Biroulet, Laurent

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Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn’s Disease von Denson, Lee A., Jurickova, Ingrid, Karns, Rebekah, Shaw, Kelly A., Cutler, David J., Okou, David T., Dodd, Anne, Quinn, Kathryn, Mondal, Kajari, Aronow, Bruce J., Haberman, Yael, Linn, Aaron, Price, Adam, Bezold, Ramona, Lake, Kathleen, Jackson, Kimberly, Walters, Thomas D., Griffiths, Anne, Baldassano, Robert N., Noe, Joshua D., Hyams, Jeffrey S., Crandall, Wallace V., Kirschner, Barbara S., Heyman, Melvin B., Snapper, Scott, Guthery, Stephen L., Dubinsky, Marla C., Leleiko, Neal S., Otley, Anthony R., Xavier, Ramnik J., Stevens, Christine, Daly, Mark J., Zwick, Michael E., Kugathasan, Subra

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A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF von Chuang, Ling-Shiang, Villaverde, Nicole, Hui, Ken Y, Mortha, Arthur, Rahman, Adeeb, Levine, Adam P, Haritunians, Talin, Evelyn Ng, Sok Meng, Zhang, Wei, Hsu, Nai-Yun, Facey, Jody-Ann, Luong, Tramy, Fernandez-Hernandez, Heriberto, Li, Dalin, Rivas, Manuel, Schiff, Elena R, Gusev, Alexander, Schumm, L. Phillip, Bowen, Beatrice M, Sharma, Yashoda, Ning, Kaida, Remark, Romain, Gnjatic, Sacha, Legnani, Peter, George, James, Sands, Bruce E, Stempak, Joanne M, Datta, Lisa W, Lipka, Seth, Katz, Seymour, Cheifetz, Adam S, Barzilai, Nir, Pontikos, Nikolas, Abraham, Clara, Dubinsky, Marla J, Targan, Stephan, Taylor, Kent, Rotter, Jerome I, Scherl, Ellen J, Desnick, Robert J, Abreu, Maria T, Zhao, Hongyu, Atzmon, Gil, Pe’er, Itsik, Kugathasan, Subra, Hakonarson, Hakon, McCauley, Jacob L, Lencz, Todd, Darvasi, Ariel, Plagnol, Vincent, Silverberg, Mark S, Muise, Aleixo M, Brant, Steven R, Daly, Mark J, Segal, Anthony W, Duerr, Richard H, Merad, Miriam, McGovern, Dermot P.B, Peter, Inga, Cho, Judy H

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Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity von Uzzan, Mathieu, Martin, Jerome C., Mesin, Luka, Livanos, Alexandra E., Castro-Dopico, Tomas, Huang, Ruiqi, Petralia, Francesca, Magri, Giuliana, Kumar, Shashi, Zhao, Qing, Rosenstein, Adam K., Tokuyama, Minami, Sharma, Keshav, Ungaro, Ryan, Kosoy, Roman, Jha, Divya, Fischer, Jeremy, Singh, Harpriya, Keir, Mary E., Ramamoorthi, Nandhini, O’Gorman, William E., Cohen, Benjamin L., Rahman, Adeeb, Cossarini, Francesca, Seki, Akihiro, Leyre, Louise, Vaquero, Sonia Tejedor, Gurunathan, Sakteesh, Grasset, Emilie K., Losic, Bojan, Dubinsky, Marla, Greenstein, Alexander J., Gottlieb, Zoe, Legnani, Peter, George, James, Irizar, Haritz, Stojmirovic, Aleksandar, Brodmerkel, Carrie, Kasarkis, Andrew, Sands, Bruce E., Furtado, Glaucia, Lira, Sergio A., Tuong, Zewen K., Ko, Huaibin M., Cerutti, Andrea, Elson, Charles O., Clatworthy, Menna R., Merad, Miriam, Suárez-Fariñas, Mayte, Argmann, Carmen, Hackney, Jason A., Victora, Gabriel D., Randolph, Gwendalyn J., Kenigsberg, Ephraim, Colombel, Jean Frederic, Mehandru, Saurabh

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Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial von Lopes, Renato D., Higano, Celestia S., Slovin, Susan F., Nelson, Adam J., Bigelow, Robert, Sørensen, Per S., Melloni, Chiara, Goodman, Shaun G., Evans, Christopher P., Nilsson, Jan, Bhatt, Deepak L., Clarke, Noel W., Olesen, Tine K., Doyle-Olsen, Belinda T., Kristensen, Henriette, Arney, Lauren, Roe, Matthew T., Alexander, John H.

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Combination Therapy With Immunomodulators Improves the Pharmacokinetics of Infliximab But Not Vedolizumab or Ustekinumab von Yarur, Andres J., McGovern, Dermot, Abreu, Maria T., Cheifetz, Adam, Papamichail, Konstantinos, Deepak, Parakkal, Bruss, Alexandra, Beniwal-Patel, Poonam, Dubinsky, Marla, Targan, Stephan R., Melmed, Gil Y.

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Appropriateness of Testing for Anti–Tumor Necrosis Factor Agent and Antibody Concentrations, and Interpretation of Results von Melmed, Gil Y, Irving, Peter M, Jones, Jennifer, Kaplan, Gilaad G, Kozuch, Patricia L, Velayos, Fernando S, Baidoo, Leonard, Sparrow, Miles P, Bressler, Brian, Cheifetz, Adam S, Devlin, Shane M, Raffals, Laura E, Casteele, Niels Vande, Mould, Diane R, Colombel, Jean-Fred, Dubinsky, Marla, Sandborn, William J, Siegel, Corey A

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236: CONCENTRATIONS OF 6-THIOGUANINE NUCLEOTIDE AND USE OF ORAL METHOTREXATE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES CORRELATE WITH A BETTER PHARMACOKINECTIC PROFILE OF INFLIX... von Yarur, Andres J., Bruss, Alexandra, Beniwal-Patel, Poonam, Papamichail, Konstantinos, Cheifetz, Adam S., Deepak, Parakkal, Abreu, Maria T., Dubinsky, Marla C., Melmed, Gil

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Quality improvement in neurology: Amyotrophic lateral sclerosis quality measures: Report of the Quality Measurement and Reporting Subcommittee of the American Academy of Neurology von Miller, Robert G, Brooks, Benjamin Rix, Swain-Eng, Rebecca J, Basner, Robert C, Carter, Gregory T, Casey, Patricia, Cohen, Adam B, Dubinsky, Richard, Forshew, Dallas, Jackson, Carlayne E, Kasarskis, Ed, Procaccini, Nicholas J, Sanjak, Mohammed, Tolin, Fredrik P

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Natural bacterial communities serve as quantitative geochemical biosensors von Smith, Mark B, Rocha, Andrea M, Smillie, Chris S, Olesen, Scott W, Paradis, Charles, Wu, Liyou, Campbell, James H, Fortney, Julian L, Mehlhorn, Tonia L, Lowe, Kenneth A, Earles, Jennifer E, Phillips, Jana, Techtmann, Steve M, Joyner, Dominique C, Elias, Dwayne A, Bailey, Kathryn L, Hurt, Jr, Richard A, Preheim, Sarah P, Sanders, Matthew C, Yang, Joy, Mueller, Marcella A, Brooks, Scott, Watson, David B, Zhang, Ping, He, Zhili, Dubinsky, Eric A, Adams, Paul D, Arkin, Adam P, Fields, Matthew W, Zhou, Jizhong, Alm, Eric J, Hazen, Terry C

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Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte–Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s Disease von Denson, Lee A, Jurickova, Ingrid, Karns, Rebekah, Shaw, Kelly A, Cutler, David J, Okou, David, Valencia, C Alexander, Dodd, Anne, Mondal, Kajari, Aronow, Bruce J, Haberman, Yael, Linn, Aaron, Price, Adam, Bezold, Ramona, Lake, Kathleen, Jackson, Kimberly, Walters, Thomas D, Griffiths, Anne, Baldassano, Robert N, Noe, Joshua D, Hyams, Jeffrey S, Crandall, Wallace V, Kirschner, Barbara S, Heyman, Melvin B, Snapper, Scott, Guthery, Stephen L, Dubinsky, Marla C, Leleiko, Neal S, Otley, Anthony R, Xavier, Ramnik J, Stevens, Christine, Daly, Mark J, Zwick, Michael E, Kugathasan, Subra

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169 A PATHOGENIC B CELL RESPONSE IN ULCERATUVE COLITIS THAT ASSOCIATES WITH TREATMENT RESISTANCE AND DISEASE COMPLICATIONS von Uzzan, Mathieu, Martin, Jerome, Kenigsberg, Ephraim, Castro-Dopico, Tomas, Huang, Ruiqi, Petralia, Francesca, Kumar, Shashibala, Keir, Mary, Ramamoorthi, Nandhini, Cohen, Benjamin L., Rahman, Adeeb, Rosenstein, Adam, Seki, Akihiro, Gurunathan, Sakteesh, Dubinsky, Marla, Clatworthy, Menna, Suarez-Farinas, Mayte, Argmann, Carmen A., Hackney, Jason A., Randolph, Gwendalyn J., Colombel, Jean Frederic, Mehandru, Saurabh

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Sa1879 – Disability in Patients with Ileal Pouch Anal Anastomosis von Kayal, Maia, Ungaro, Ryan C., Riggs, Alexa, Kamal, Kanika, Agrawal, Manasi, Cohen-Mekelburg, Shirley, Axelrad, Jordan E., Tricomi, Brad, Faye, Adam S., Scherl, Ellen, Lawlor, Garrett, Lukin, Dana J., Colombel, Jean Frederic, Dubinsky, Marla

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Sa1761 AN INTERDISCIPLINARY CARE PROGRAM FOR RECENTLY DIAGNOSED INFLAMMATORY BOWEL DISEASE PATIENTS IS ASSOCIATED WITH INCREASED CLINICAL REMISSION RATES AND LOWER STEROID USE von Ungaro, Ryan C., Ho, Melissa, Stanley, Stephanie, Carrero, William J. Rivera, Castillo, Anabella, Sherman, Alexis, Tse, Stacy, Manning, Laura, Hyne, Amanda, Matos, Kristina, Kamal, Kanika, Helmus, Drew, Rodriguez, Maria Carina, Marion, James F., Steinlauf, Adam F., Chapman, Mark, Itzkowitz, Steven, Sands, Bruce E., Hirten, Robert, Kayal, Maia, Maser, Elana, Cohen, Benjamin, Cohen, Louis, Colombel, Jean Frederic, Grinspan, Ari, Keefer, Laurie, Dubinsky, Marla C

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565 TRANSCRIPTOMIC AND PHENOTYPIC CHARACTERIZATION OF A PATHOGENIC B CELL RESPONSE IN ULCERATIVE COLITIS THAT ASSOCIATES WITH TREATMENT RESISTANCE AND DISEASE COMPLICATIONS von Uzzan, Mathieu, Martin, Jerome, KENIGSBERG, EFFI, Huang, Ruiqi, CASTRODOPICO, TOMAS, Petralia, Francesca, KUMAR, SHASHIBALA, Keir, Mary, Ramamoorthi, Nandhini, O'Gorman, William, Ungaro, Ryan C., Cohen, Benjamin L., Rahman, Adeeb, Rosenstein, Adam, Seki, Akihiro, Jha, Divya, Cossarini, Francesca, sharma, keshav, Gurunathan, Sakteesh, Dubinsky, Marla, Clatworthy, Menna, Suarez-Farinas, Mayte, Argmann, Carmen A., Hackney, Jason A., Randolph, Gwendalyn J., Colombel, Jean Frederic, Mehandru, Saurabh

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378 - Genomic Correlates of Reduced Neutrophil Granulocytemacrophage Colony Stimulating Factor Signaling in Stricturing Pediatric Crohn Disease von Jurickova, Ingrid, Karns, Rebekah, Cutler, David J., Okou, David, Dodd, Ann, Mondal, Kajari, Aronow, Bruce J., Haberman, Yael, Linn, Aaron, Price, Adam, Bezold, Ramona, Lake, Kathleen, Jackson, Kimberly, Walters, Thomas D., Griffiths, Anne M., Baldassano, Robert N., Noe, Joshua D., Hyams, Jeffrey S., Crandall, Wallace V., Kirschner, Barbara S., Heyman, Melvin B., Snapper, Scott B., Guthery, Stephen, Dubinsky, Marla, Leleiko, Neal S., Otley, Anthony, Xavier, Ramnik, Stevens, Christine, Daly, Mark J., Zwick, Michael E., Kugathasan, Subra, Denson, Lee A.

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27 CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE von Denson, Lee A., Jurickova, Ingrid, Karns, Rebekah, Shaw, Kelly A., Cutler, David J., Okou, David, Dodd, Anne, Mondal, Kajari, Aronow, Bruce J., Haberman, Yael, Linn, Aaron, Price, Adam, Bezold, Ramona, Lake, Kathleen, Jackson, Kimberly, Walters, Thomas D., Griffiths, Anne, Baldassano, Robert N., Noe, Joshua D., Hyams, Jeffrey S., Crandall, Wallace V., Kirschner, Barbara S., Heyman, Melvin B., Snapper, Scott, Guthery, Stephen L., Dubinsky, Marla C., Leleiko, Neal S., Otley, Anthony R., Xavier, Ramnik J., Stevens, Christine, Daly, Mark J., Zwick, Michael E., Kugathasan, Subra

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27 CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE von Denson, Lee A, Jurickova, Ingrid, Karns, Rebekah, Shaw, Kelly A, Cutler, David J, Okou, David, Dodd, Anne, Mondal, Kajari, Aronow, Bruce J, Haberman, Yael, Linn, Aaron, Price, Adam, Bezold, Ramona, Lake, Kathleen, Jackson, Kimberly, Walters, Thomas D, Griffiths, Anne, Baldassano, Robert N, Noe, Joshua D, Hyams, Jeffrey S, Crandall, Wallace V, Kirschner, Barbara S, Heyman, Melvin B, Snapper, Scott, Guthery, Stephen L, Dubinsky, Marla C, Leleiko, Neal S, Otley, Anthony R, Xavier, Ramnik J, Stevens, Christine, Daly, Mark J, Zwick, Michael E, Kugathasan, Subra

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A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn’s Disease and Reduces Monocyte Signaling via GMCSF von Chuang, Ling-Shiang, Villaverde, Nicole, Hui, Ken Y., Mortha, Arthur, Rahman, Adeeb, Levine, Adam P., Haritunians, Talin, Evelyn Ng, Sok Meng, Zhang, Wei, Hsu, Nai-Yun, Facey, Jody-Ann, Luong, Tramy, Fernandez-Hernandez, Heriberto, Li, Dalin, Rivas, Manuel, Schiff, Elena R., Gusev, Alexander, Schumm, L. Phillip, Bowen, Beatrice M., Sharma, Yashoda, Ning, Kaida, Remark, Romain, Gnjatic, Sacha, Legnani, Peter, George, James, Sands, Bruce E., Stempak, Joanne M., Datta, Lisa W., Lipka, Seth, Katz, Seymour, Cheifetz, Adam S., Barzilai, Nir, Pontikos, Nikolas, Abraham, Clara, Dubinsky, Marla J., Targan, Stephan, Taylor, Kent, Rotter, Jerome I, Scherl, Ellen J., Desnick, Robert J., Abreu, Maria T., Zhao, Hongyu, Atzmon, Gil, Pe’er, Itsik, Kugathasan, Subra, Hakonarson, Hakon, McCauley, Jacob L., Lencz, Todd, Darvasi, Ariel, Plagnol, Vincent, Silverberg, Mark S., Muise, Aleixo M., Brant, Steven R., Daly, Mark J., Segal, Anthony W., Duerr, Richard H., Merad, Miriam, McGovern, Dermot P.B., Peter, Inga, Cho, Judy H.

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