Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish von Yan, Chuan, Brunson, Dalton C., Tang, Qin, Do, Daniel, Iftimia, Nicolae A., Moore, John C., Hayes, Madeline N., Welker, Alessandra M., Garcia, Elaine G., Dubash, Taronish D., Hong, Xin, Drapkin, Benjamin J., Myers, David T., Phat, Sarah, Volorio, Angela, Marvin, Dieuwke L., Ligorio, Matteo, Dershowitz, Lyle, McCarthy, Karin M., Karabacak, Murat N., Fletcher, Jonathan A., Sgroi, Dennis C., Iafrate, John A., Maheswaran, Shyamala, Dyson, Nick J., Haber, Daniel A., Rawls, John F., Langenau, David M.

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Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer von Farago, Anna F, Yeap, Beow Y, Stanzione, Marcello, Hung, Yin P, Heist, Rebecca S, Marcoux, J Paul, Zhong, Jun, Rangachari, Deepa, Barbie, David A, Phat, Sarah, Myers, David T, Morris, Robert, Kem, Marina, Dubash, Taronish D, Kennedy, Elizabeth A, Digumarthy, Subba R, Sequist, Lecia V, Hata, Aaron N, Maheswaran, Shyamala, Haber, Daniel A, Lawrence, Michael S, Shaw, Alice T, Mino-Kenudson, Mari, Dyson, Nicholas J, Drapkin, Benjamin J

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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells von Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D., Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R., Glimm, Hanno, Spang, Rainer, Boutros, Michael

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TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state von Matsuda, Satoru, Revandkar, Ajinkya, Dubash, Taronish D., Ravi, Arvind, Wittner, Ben S., Lin, Maoxuan, Morris, Robert, Burr, Risa, Guo, Hongshan, Seeger, Karsen, Szabolcs, Annamaria, Che, Dante, Nieman, Linda, Getz, Gad A., Ting, David T., Lawrence, Michael S., Gainor, Justin, Haber, Daniel A., Maheswaran, Shyamala

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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer von Guo, Hongshan, Golczer, Gabriel, Wittner, Ben S., Langenbucher, Adam, Zachariah, Marcus, Dubash, Taronish D., Hong, Xin, Comaills, Valentine, Burr, Risa, Ebright, Richard Y., Horwitz, Elad, Vuille, Joanna A., Hajizadeh, Soroush, Wiley, Devon F., Reeves, Brittany A., Zhang, Jia-min, Niederhoffer, Kira L., Lu, Chenyue, Wesley, Benjamin, Ho, Uyen, Nieman, Linda T., Toner, Mehmet, Vasudevan, Shobha, Zou, Lee, Mostoslavsky, Raul, Maheswaran, Shyamala, Lawrence, Michael S., Haber, Daniel A.

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The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo von Weber, Sarah, Koschade, Sebastian E, Hoffmann, Christopher M, Dubash, Taronish D, Giessler, Klara M, Dieter, Sebastian M, Herbst, Friederike, Glimm, Hanno, Ball, Claudia R

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Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts von Ball, Claudia R, Oppel, Felix, Ehrenberg, Karl Roland, Dubash, Taronish D, Dieter, Sebastian M, Hoffmann, Christopher M, Abel, Ulrich, Herbst, Friederike, Koch, Moritz, Werner, Jens, Bergmann, Frank, Ishaque, Naveed, Schmidt, Manfred, von Kalle, Christof, Scholl, Claudia, Fröhling, Stefan, Brors, Benedikt, Weichert, Wilko, Weitz, Jürgen, Glimm, Hanno

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Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells von Mishra, Avanish, Dubash, Taronish D., Edd, Jon F., Jewett, Michelle K., Garre, Suhaas G., Karabacak, Nezihi Murat, Rabe, Daniel C., Mutlu, Baris R., Walsh, John R., Kapur, Ravi, Stott, Shannon L., Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet

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The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis von Hong, Xin, Roh, Whijae, Sullivan, Ryan J, Wong, Keith H K, Wittner, Ben S, Guo, Hongshan, Dubash, Taronish D, Sade-Feldman, Moshe, Wesley, Benjamin, Horwitz, Elad, Boland, Genevieve M, Marvin, Dieuwke L, Bonesteel, Todd, Lu, Chenyue, Aguet, François, Burr, Risa, Freeman, Samuel S, Parida, Laxmi, Calhoun, Katherine, Jewett, Michelle K, Nieman, Linda T, Hacohen, Nir, Näär, Anders M, Ting, David T, Toner, Mehmet, Stott, Shannon L, Getz, Gad, Maheswaran, Shyamala, Haber, Daniel A

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Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes von Edd, Jon F, Mishra, Avanish, Dubash, Taronish D, Herrera, Stefan, Mohammad, Ridhwan, Williams, E. Kendall, Hong, Xin, Mutlu, Baris R, Walsh, John R, Machado de Carvalho, Fernanda, Aldikacti, Berent, Nieman, Linda T, Stott, Shannon L, Kapur, Ravi, Maheswaran, Shyamala, Haber, Daniel A, Toner, Mehmet

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Systematic Generation of Patient-Derived Tumor Models in Pancreatic Cancer von Ehrenberg, Karl Roland, Gao, Jianpeng, Oppel, Felix, Frank, Stephanie, Kang, Na, Dieter, Sebastian M, Herbst, Friederike, Möhrmann, Lino, Dubash, Taronish D, Schulz, Erik R, Strakerjahn, Hendrik, Giessler, Klara M, Weber, Sarah, Oberlack, Ava, Rief, Eva-Maria, Strobel, Oliver, Bergmann, Frank, Lasitschka, Felix, Weitz, Jürgen, Glimm, Hanno, Ball, Claudia R

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Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA von Sundaresan, Tilak K., Dubash, Taronish D., Zheng, Zongli, Bardia, Aditya, Wittner, Ben S., Aceto, Nicola, Silva, Erin J., Fox, Douglas B., Liebers, Matthew, Kapur, Ravi, Iafrate, John, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.

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Modeling the novel SERD elacestrant in cultured fulvestrant-refractory HR-positive breast circulating tumor cells von Dubash, Taronish D., Bardia, Aditya, Chirn, Brian, Reeves, Brittany A., LiCausi, Joseph A., Burr, Risa, Wittner, Ben S., Rai, Sumit, Patel, Hitisha, Bihani, Teeru, Arlt, Heike, Bidard, Francois-Clement, Kaklamani, Virginia G., Aftimos, Philippe, Cortés, Javier, Scartoni, Simona, Fiascarelli, Alessio, Binaschi, Monica, Habboubi, Nassir, Iafrate, A. John, Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala

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Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition von Karabacak, Nezihi Murat, Zheng, Yu, Dubash, Taronish D, Burr, Risa, Micalizzi, Douglas S, Wittner, Ben S, Lin, Maoxuan, Wiley, Devon F, Comaills, Valentine, Emmons, Erin, Niederhoffer, Kira L, Ho, Uyen, Ukleja, Jacob, Che, Dante, Stowe, Hannah, Nieman, Linda T, Haas, Wilhelm, Stott, Shannon L, Lawrence, Michael S, Ting, David T, Miyamoto, David T, Haber, Daniel A, Toner, Mehmet, Maheswaran, Shyamala

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Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer von Giessler, Klara M, Kleinheinz, Kortine, Huebschmann, Daniel, Balasubramanian, Gnana Prakash, Dubash, Taronish D, Dieter, Sebastian M, Siegl, Christine, Herbst, Friederike, Weber, Sarah, Hoffmann, Christopher M, Fronza, Raffaele, Buchhalter, Ivo, Paramasivam, Nagarajan, Eils, Roland, Schmidt, Manfred, von Kalle, Christof, Schneider, Martin, Ulrich, Alexis, Scholl, Claudia, Fröhling, Stefan, Weichert, Wilko, Brors, Benedikt, Schlesner, Matthias, Ball, Claudia R, Glimm, Hanno

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Patient‐derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B‐lymphoproliferation von Dieter, Sebastian M., Giessler, Klara M., Kriegsmann, Mark, Dubash, Taronish D., Möhrmann, Lino, Schulz, Erik R., Siegl, Christine, Weber, Sarah, Strakerjahn, Hendrik, Oberlack, Ava, Heger, Ulrike, Gao, Jianpeng, Hartinger, Eva‐Maria, Oppel, Felix, Hoffmann, Christopher M., Ha, Nati, Brors, Benedikt, Lasitschka, Felix, Ulrich, Alexis, Strobel, Oliver, Schmidt, Manfred, von Kalle, Christof, Schneider, Martin, Weichert, Wilko, Ehrenberg, K. Roland, Glimm, Hanno, Ball, Claudia R.

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Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells von Dubash, Taronish D, Hoffmann, Christopher M, Oppel, Felix, Giessler, Klara M, Weber, Sarah, Dieter, Sebastian M, Hüllein, Jennifer, Zenz, Thorsten, Herbst, Friederike, Scholl, Claudia, Weichert, Wilko, Werft, Wiebke, Benner, Axel, Schmidt, Manfred, Schneider, Martin, Glimm, Hanno, Ball, Claudia R

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Blood-based monitoring identifies acquired and targetable driver HER2 mutations in endocrine-resistant metastatic breast cancer von Medford, Arielle J., Dubash, Taronish D., Juric, Dejan, Spring, Laura, Niemierko, Andrzej, Vidula, Neelima, Peppercorn, Jeffrey, Isakoff, Steven, Reeves, Brittany A., LiCausi, Joseph A., Wesley, Benjamin, Malvarosa, Giuliana, Yuen, Megan, Wittner, Ben S., Lawrence, Michael S., Iafrate, A. John, Ellisen, Leif, Moy, Beverly, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A., Bardia, Aditya

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Abstract 910: Genetic subclone heterogeneity of the human colon cancer initiating cell compartment von Giessler, Klara M., Kleinheinz, Kortine, Balasubramanian, Gnana Prakash, Hübschmann, Daniel, Dubash Rai, Taronish D., Dieter, Sebastian D., Siegl, Christine, Hoffmann, Christopher M., Weber, Sarah, Fronza, Raffaele, Afzal, Saira, Schmidt, Manfred, Schneider, Martin, Ulrich, Alexis, Weitz, Juergen, Weichert, Wilko, Schlesner, Matthias, Brors, Benedikt, Ball, Claudia R., Glimm, Hanno

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In-flow measurement of cell-cell adhesion using oscillatory inertial microfluidics von Mutlu, Baris R, Dubash, Taronish, Dietsche, Claudius, Mishra, Avanish, Ozbey, Arzu, Keim, Kevin, Edd, Jon F, Haber, Daniel A, Maheswaran, Shyamala, Toner, Mehmet

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