VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research von Lai, Zhongwu, Markovets, Aleksandra, Ahdesmaki, Miika, Chapman, Brad, Hofmann, Oliver, McEwen, Robert, Johnson, Justin, Dougherty, Brian, Barrett, J Carl, Dry, Jonathan R

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Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response von Sidders, Ben, Zhang, Pei, Goodwin, Kelly, O'Connor, Greg, Russell, Deanna L., Borodovsky, Alexandra, Armenia, Joshua, McEwen, Robert, Linghu, Bolan, Bendell, Johanna C., Bauer, Todd M., Patel, Manish R., Falchook, Gerald S., Merchant, Melinda, Pouliot, Gayle, Barrett, J. Carl, Dry, Jonathan R., Woessner, Rich, Sachsenmeier, Kris

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Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer von Gogleva, Anna, Polychronopoulos, Dimitris, Pfeifer, Matthias, Poroshin, Vladimir, Ughetto, Michaël, Martin, Matthew J., Thorpe, Hannah, Bornot, Aurelie, Smith, Paul D., Sidders, Ben, Dry, Jonathan R., Ahdesmäki, Miika, McDermott, Ultan, Papa, Eliseo, Bulusu, Krishna C.

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AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies von Rhyasen, Garrett W, Hattersley, Maureen M, Yao, Yi, Dulak, Austin, Wang, Wenxian, Petteruti, Philip, Dale, Ian L, Boiko, Scott, Cheung, Tony, Zhang, Jingwen, Wen, Shenghua, Castriotta, Lillian, Lawson, Deborah, Collins, Michael, Bao, Larry, Ahdesmaki, Miika J, Walker, Graeme, O'Connor, Greg, Yeh, Tammie C, Rabow, Alfred A, Dry, Jonathan R, Reimer, Corinne, Lyne, Paul, Mills, Gordon B, Fawell, Stephen E, Waring, Michael J, Zinda, Michael, Clark, Edwin, Chen, Huawei

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Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets von Lai, Zhongwu, Brosnan, Matthew, Sokol, Ethan S, Xie, Mingchao, Dry, Jonathan R, Harrington, Elizabeth A, Barrett, J Carl, Hodgson, Darren

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Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models von Eberlein, Catherine A, Stetson, Daniel, Markovets, Aleksandra A, Al-Kadhimi, Katherine J, Lai, Zhongwu, Fisher, Paul R, Meador, Catherine B, Spitzler, Paula, Ichihara, Eiki, Ross, Sarah J, Ahdesmaki, Miika J, Ahmed, Ambar, Ratcliffe, Laura E, O'Brien, Elizabeth L Christey, Barnes, Claire H, Brown, Henry, Smith, Paul D, Dry, Jonathan R, Beran, Garry, Thress, Kenneth S, Dougherty, Brian, Pao, William, Cross, Darren A E

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Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors von Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.

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Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort von Leibowitz, Benjamin D, Dougherty, Bonnie V, Bell, Joshua S K, Kapilivsky, Joshuah, Michuda, Jackson, Sedgewick, Andrew J, Munson, Wesley A, Chandra, Tushar A, Dry, Jonathan R, Beaubier, Nike, Igartua, Catherine, Taxter, Timothy

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Defining actionable mutations for oncology therapeutic development von Carr, T. Hedley, McEwen, Robert, Dougherty, Brian, Johnson, Justin H., Dry, Jonathan R., Lai, Zhongwu, Ghazoui, Zara, Laing, Naomi M., Hodgson, Darren R., Cruzalegui, Francisco, Hollingsworth, Simon J., Barrett, J. Carl

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Looking beyond the cancer cell for effective drug combinations von Dry, Jonathan R, Yang, Mi, Saez-Rodriguez, Julio

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Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244) von DRY, Jonathan R, PAVEY, Sandra, GRAHAM, Alexander, BERAN, Garry, CASSIDY, Andrew, HAGGERTY, Carolyn, BROWN, Helen, ELLISON, Gillian, DERING, Judy, TAYLOR, Barry S, STARK, Mitchell, BONAZZI, Vanessa, PRATILAS, Christine A, RAVISHANKAR, Sugandha, PACKER, Leisl, FENG XING, SOLIT, David B, FINN, Richard S, ROSEN, Neal, HAYWARD, Nicholas K, FRENCH, Tim, SMITH, Paul D, HARBRON, Chris, RUNSWICK, Sarah, HODGSON, Darren, CHRESTA, Christine, MCCORMACK, Rose, BYRNE, Natalie, COCKERILL, Mark

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Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia von Silverbush, Dana, Grosskurth, Shaun, Wang, Dennis, Powell, Francoise, Gottgens, Berthold, Dry, Jonathan, Fisher, Jasmin

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DeePaN: deep patient graph convolutional network integrating clinico-genomic evidence to stratify lung cancers for immunotherapy von Fang, Chao, Xu, Dong, Su, Jing, Dry, Jonathan R, Linghu, Bolan

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A pan-cancer organoid platform for precision medicine von Larsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing, Khullar, Gaurav, Krantz, Benjamin A., Mapes, Brandon, McKinnon, Kelly E., Metti, Jessica, Perera, Jason F., Rand, Tim A., Sanchez-Freire, Veronica, Shaxted, Jenna M., Stein, Michelle M., Streit, Michael A., Tan, Yi-Hung Carol, Zhang, Yilin, Zhao, Ende, Venkataraman, Jagadish, Stumpe, Martin C., Borgia, Jeffrey A., Masood, Ashiq, Catenacci, Daniel V.T., Mathews, Jeremy V., Gursel, Demirkan B., Wei, Jian-Jun, Welling, Theodore H., Simeone, Diane M., White, Kevin P., Khan, Aly A., Igartua, Catherine, Salahudeen, Ameen A.

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Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion von Kudo, Rei, Safonov, Anton, Jones, Catherine, Moiso, Enrico, Dry, Jonathan R., Shao, Hong, Nag, Sharanya, da Silva, Edaise M., Yildirim, Selma Yeni, Li, Qing, O'Connell, Elizabeth, Patel, Payal, Will, Marie, Fushimi, Atsushi, Benitez, Marimar, Bradic, Martina, Fan, Li, Nakshatri, Harikrishna, Sudhan, Dhivya R., Denz, Christopher R., Huerga Sanchez, Iker, Reis-Filho, Jorge S., Goel, Shom, Koff, Andrew, Weigelt, Britta, Khan, Qamar J., Razavi, Pedram, Chandarlapaty, Sarat

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Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion von Kudo, Rei, Safonov, Anton, Jones, Catherine, Moiso, Enrico, Dry, Jonathan R., Shao, Hong, Nag, Sharanya, da Silva, Edaise M., Yildirim, Selma Yeni, Li, Qing, O’Connell, Elizabeth, Patel, Payal, Will, Marie, Fushimi, Atsushi, Benitez, Marimar, Bradic, Martina, Fan, Li, Nakshatri, Harikrishna, Sudhan, Dhivya R., Denz, Christopher R., Reis-Filho, Jorge S., Goel, Shom, Koff, Andrew, Weigelt, Britta, Khan, Qamar J., Razavi, Pedram, Chandarlapaty, Sarat

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Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells von Little, Annette S, Balmanno, Kathryn, Sale, Matthew J, Newman, Scott, Dry, Jonathan R, Hampson, Mark, Edwards, Paul A W, Smith, Paul D, Cook, Simon J

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A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates von Wang, Dennis, Hensman, James, Kutkaite, Ginte, Toh, Tzen S., Galhoz, Ana, Dry, Jonathan R., Saez-Rodriguez, Julio, Garnett, Mathew J., Menden, Michael P., Dondelinger, Frank

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Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs von Wappett, Mark, Dulak, Austin, Yang, Zheng Rong, Al-Watban, Abdullatif, Bradford, James R, Dry, Jonathan R

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The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells von Criscione, Steven W., Martin, Matthew J., Oien, Derek B., Gorthi, Aparna, Miragaia, Ricardo J., Zhang, Jingwen, Chen, Huawei, Karl, Daniel L., Mendler, Kerrin, Markovets, Aleksandra, Gagrica, Sladjana, Delpuech, Oona, Dry, Jonathan R., Grondine, Michael, Hattersley, Maureen M., Urosevic, Jelena, Floc’h, Nicolas, Drew, Lisa, Yao, Yi, Smith, Paul D.

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