Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia von Hochhaus, A, O'Brien, S G, Guilhot, F, Druker, B J, Branford, S, Foroni, L, Goldman, J M, Müller, M C, Radich, J P, Rudoltz, M, Mone, M, Gathmann, I, Hughes, T P, Larson, R A

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Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors von Traer, E, MacKenzie, R, Snead, J, Agarwal, A, Eiring, A M, O'Hare, T, Druker, B J, Deininger, M W

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Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy von HOCHHAUS, A, KREIL, S, GSCHAIDMEIER, H, DRUKER, B. J, HEHLMANN, R, CORBIN, A. S, ROSEE, P. La, MÜLLER, M. C, LAHAYE, T, HANFSTEIN, B, SCHOCH, C, CROSS, N. C. P, BERGER, U

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Age-related mutations and chronic myelomonocytic leukemia von Mason, C C, Khorashad, J S, Tantravahi, S K, Kelley, T W, Zabriskie, M S, Yan, D, Pomicter, A D, Reynolds, K R, Eiring, A M, Kronenberg, Z, Sherman, R L, Tyner, J W, Dalley, B K, Dao, K-H, Yandell, M, Druker, B J, Gotlib, J, O'Hare, T, Deininger, M W

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Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia von Watanabe-Smith, K, Tognon, C, Tyner, J W, Meijerink, J P P, Druker, B J, Agarwal, A

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Targeting survivin and p53 in pediatric acute lymphoblastic leukemia von Tyner, J W, Jemal, A M, Thayer, M, Druker, B J, Chang, B H

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Recurrent cyclin D2 mutations in myeloid neoplasms von Khanna, V, Eide, C A, Tognon, C E, Maxson, J E, Wilmot, B, Bottomly, D, McWeeney, S, Edwards V, D K, Druker, B J, Tyner, J W

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Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative von BUCHDUNGER, E, ZIMMERMANN, J, METT, H, MEYER, T, MÜLLER, M, DRUKER, B. J, LYDON, N. B

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Mutations of the BCR-ABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib von SHERBENOU, D. W, WONG, M. J, DEININGER, M. W, HUMAYUN, A, MCGREEVEY, L. S, HARRELL, P, YANG, R, MAURO, M, HEINRICH, M. C, PRESS, R. D, DRUKER, B. J

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Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells von CHUAH, C, BARNES, D. J, KWOK, M, CORBIN, A, DEININGER, M. W. N, DRUKER, B. J, MELO, J. V

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Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia von Sherbenou, D W, Hantschel, O, Turaga, L, Kaupe, I, Willis, S, Bumm, T, Press, R D, Superti-Furga, G, Druker, B J, Deininger, M W

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Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography von DEININGER, M. W. N, MCGREEVEY, L, WILLIS, S, BAINBRIDGE, T. M, DRUKER, B. J, HEINRICH, M. C

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An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia von Agarwal, A, Eide, C A, Harlow, A, Corbin, A S, Mauro, M J, Druker, B J, Corless, C L, Heinrich, M C, Deininger, M W

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CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when c... von Prins, R C, Burke, R T, Tyner, J W, Druker, B J, Loriaux, M M, Spurgeon, S E

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Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: a tr... von La Rosée, P, O'Dwyer, M E, Druker, B J

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Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia von Druker, B J, Lydon, N B

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Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia von Druker, Brian J, Talpaz, Moshe, Resta, Debra J, Peng, Bin, Buchdunger, Elisabeth, Ford, John M, Lydon, Nicholas B, Kantarjian, Hagop, Capdeville, Renaud, Ohno-Jones, Sayuri, Sawyers, Charles L

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Thrombopoietin Induces Tyrosine Phosphorylation of Stat3 and Stat5 in Human Blood Platelets von Miyakawa, Yoshitaka, Oda, Atsushi, Druker, Brian J., Miyazaki, Hiroshi, Handa, Makoto, Ohashi, Hideya, Ikeda, Yasuo

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Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome von Druker, Brian J, Sawyers, Charles L, Kantarjian, Hagop, Resta, Debra J, Reese, Sofia Fernandes, Ford, John M, Capdeville, Renaud, Talpaz, Moshe

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Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate von O'Dwyer, M E, Gatter, K M, Loriaux, M, Druker, B J, Olson, S B, Magenis, R E, Lawce, H, Mauro, M J, Maziarz, R T, Braziel, R M

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