A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes von Batista, Thiago M., Jayavelu, Ashok Kumar, Wewer Albrechtsen, Nicolai J., Iovino, Salvatore, Lebastchi, Jasmin, Pan, Hui, Dreyfuss, Jonathan M., Krook, Anna, Zierath, Juleen R., Mann, Matthias, Kahn, C. Ronald

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FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy von O'Neill, Brian T, Bhardwaj, Gourav, Penniman, Christie M, Krumpoch, Megan T, Suarez Beltran, Pablo A, Klaus, Katherine, Poro, Kennedy, Li, Mengyao, Pan, Hui, Dreyfuss, Jonathan M, Nair, K Sreekumaran, Kahn, C Ronald

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Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites von Fujisaka, Shiho, Avila-Pacheco, Julian, Soto, Marion, Kostic, Aleksandar, Dreyfuss, Jonathan M., Pan, Hui, Ussar, Siegfried, Altindis, Emrah, Li, Ning, Bry, Lynn, Clish, Clary B., Kahn, C. Ronald

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Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression von Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M., O’Neill, Brian T., Ramirez, Alfred K., Pan, Hui, Winnay, Jonathon N., Boucher, Jeremie, Eck, Michael J., Kahn, C. Ronald

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Antibiotic effects on gut microbiota and metabolism are host dependent von Fujisaka, Shiho, Ussar, Siegfried, Clish, Clary, Devkota, Suzanne, Dreyfuss, Jonathan M, Sakaguchi, Masaji, Soto, Marion, Konishi, Masahiro, Softic, Samir, Altindis, Emrah, Li, Ning, Gerber, Georg, Bry, Lynn, Kahn, C Ronald

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Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy von Gordin, Daniel, Shah, Hetal, Shinjo, Takanori, St-Louis, Ronald, Qi, Weier, Park, Kyoungmin, Paniagua, Samantha M, Pober, David M, Wu, I-Hsien, Bahnam, Vanessa, Brissett, Megan J, Tinsley, Liane J, Dreyfuss, Jonathan M, Pan, Hui, Dong, Yutong, Niewczas, Monika A, Amenta, Peter, Sadowski, Thorsten, Kannt, Aimo, Keenan, Hillary A, King, George L

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Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis von Nagao, Hirofumi, Jayavelu, Ashok Kumar, Cai, Weikang, Pan, Hui, Dreyfuss, Jonathan M., Batista, Thiago M., Brandão, Bruna B., Mann, Matthias, Kahn, C. Ronald

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SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms von Osataphan, Soravis, Macchi, Chiara, Singhal, Garima, Chimene-Weiss, Jeremy, Sales, Vicencia, Kozuka, Chisayo, Dreyfuss, Jonathan M, Pan, Hui, Tangcharoenpaisan, Yanin, Morningstar, Jordan, Gerszten, Robert, Patti, Mary-Elizabeth

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Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence von Steinbaugh, Michael J, Narasimhan, Sri Devi, Robida-Stubbs, Stacey, Moronetti Mazzeo, Lorenza E, Dreyfuss, Jonathan M, Hourihan, John M, Raghavan, Prashant, Operaña, Theresa N, Esmaillie, Reza, Blackwell, T Keith

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Reconstruction and validation of a genome-scale metabolic model for the filamentous fungus Neurospora crassa using FARM von Dreyfuss, Jonathan M, Zucker, Jeremy D, Hood, Heather M, Ocasio, Linda R, Sachs, Matthew S, Galagan, James E

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High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control von Dreyfuss, Jonathan M., Yuchi, Yixing, Dong, Xuehong, Efthymiou, Vissarion, Pan, Hui, Simonson, Donald C., Vernon, Ashley, Halperin, Florencia, Aryal, Pratik, Konkar, Anish, Sebastian, Yinong, Higgs, Brandon W., Grimsby, Joseph, Rondinone, Cristina M., Kasif, Simon, Kahn, Barbara B., Foster, Kathleen, Seeley, Randy, Goldfine, Allison, Djordjilović, Vera, Patti, Mary Elizabeth

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The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response von Lavoie, Sydney, Conway, Kara L, Lassen, Kara G, Jijon, Humberto B, Pan, Hui, Chun, Eunyoung, Michaud, Monia, Lang, Jessica K, Gallini Comeau, Carey Ann, Dreyfuss, Jonathan M, Glickman, Jonathan N, Vlamakis, Hera, Ananthakrishnan, Ashwin, Kostic, Aleksander, Garrett, Wendy S, Xavier, Ramnik J

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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling von Nagao, Hirofumi, Cai, Weikang, Brandão, Bruna B, Wewer Albrechtsen, Nicolai J, Steger, Martin, Gattu, Arijeet K, Pan, Hui, Dreyfuss, Jonathan M, Wunderlich, F Thomas, Mann, Matthias, Kahn, C Ronald

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Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets von Basile, Giorgio, Kahraman, Sevim, Dirice, Ercument, Pan, Hui, Dreyfuss, Jonathan M, Kulkarni, Rohit N

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Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism von Lerin, Carles, Goldfine, Allison B, Boes, Tanner, Liu, Manway, Kasif, Simon, Dreyfuss, Jonathan M, De Sousa-Coelho, Ana Luisa, Daher, Grace, Manoli, Irini, Sysol, Justin R, Isganaitis, Elvira, Jessen, Niels, Goodyear, Laurie J, Beebe, Kirk, Gall, Walt, Venditti, Charles P, Patti, Mary-Elizabeth

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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance von Shirakawa, Jun, Togashi, Yu, Basile, Giorgio, Okuyama, Tomoko, Inoue, Ryota, Fernandez, Megan, Kyohara, Mayu, De Jesus, Dario F., Goto, Nozomi, Zhang, Wei, Tsuno, Takahiro, Kin, Tatsuya, Pan, Hui, Dreyfuss, Jonathan M., Shapiro, A.M. James, Yi, Peng, Terauchi, Yasuo, Kulkarni, Rohit N.

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FoxK1 associated gene regulatory network in hepatic insulin action and its relationship to FoxO1 and insulin receptor mediated transcriptional regulation von Allu, Prasanna K.R., Cardamone, Maria Dafne, Gomes, Antonio S., Dall'agnese, Alessandra, Cederquist, Carly, Pan, Hui, Dreyfuss, Jonathan M., Enerbäck, Sven, Kahn, C. Ronald

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Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors von Bhardwaj, Gourav, Penniman, Christie M, Klaus, Katherine, Weatherford, Eric T, Pan, Hui, Dreyfuss, Jonathan M, Nair, K Sreekumaran, Kahn, C Ronald, O'Neill, Brian T

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Developmental and functional heterogeneity of white adipocytes within a single fat depot von Lee, Kevin Y, Luong, Quyen, Sharma, Rita, Dreyfuss, Jonathan M, Ussar, Siegfried, Kahn, C Ronald

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Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells von Costa, S M R, Isganaitis, E, Matthews, T J, Hughes, K, Daher, G, Dreyfuss, J M, da Silva, G A P, Patti, M-E

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